Inclusion Criteria:

          1. Histologically or cytologically confirmed adenocarcinoma of the prostate

          2. Documented metastatic castration resistant disease with PSA progression, radiographic
             progression, or both, despite medical or surgical castration

          3. Two or more bone metastases detected on skeletal scintigraphy

          4. Eligible for docetaxel chemotherapy

          5. ECOG Performance Status 0-2

          6. Adequate organ function:

               1. Hemoglobin > 10 g/dL

               2. Absolute Neutrophil Count ≥ 1,500 K/mL

               3. Platelet count ≥ 150,000 x 10^9/L

               4. Total bilirubin ≤ 1.5x upper limit of normal range, excluding Gilbert syndrome

               5. Serum AST ≤ 1.5 x upper limit of normal range

               6. Serum ALT ≤ 1.5 x upper limit of normal range

          7. Estimated glomerular filtration rate (GFR) > 30mL/min

          8. Ongoing castration (androgen deprivation therapy or prior orchiectomy)

          9. Male subjects with female sexual partners of childbearing potential must agree to use
             at least one highly effective methods of birth control.

         10. Ability to understand and willingness to sign an informed consent form prior to
             initiation of any study procedures.

         11. Age ≥ 18 years

        Exclusion Criteria:

          1. Prior radionuclide therapy for CRPC

          2. Prior docetaxel for CRPC. (Permitted if given for castration sensitive disease > 6
             months prior).

          3. Antiandrogen therapy within 4 weeks of enrollment. However, patients with primary
             failure of secondary anti-androgen therapy OR symptomatic progression, objective
             progression and/or biochemical evidence of rising PSA less than 4 weeks after
             discontinuation of anti-androgen therapy will not have anti-androgen withdrawal
             responses and will not be excluded.

          4. Preexisting peripheral neuropathy grade 2 or higher.

          5. Other serious medical condition as judged by the investigator.

          6. Active second malignancy that requires therapy.

          7. Known brain or leptomeningeal metastases

          8. Concurrent enrollment in any other investigational anticancer therapy

          9. Treatment with any myelosuppressive agent within 30 days of enrollment

         10. Presence of bulky visceral metastases, defined as any of the following:

               1. ≥ 4 lung lesions (at least 1cm each in size in the longest diameter) or pulmonary
                  lymphangitic metastasis

               2. Liver metastases with sum of lesion diameters totaling ≥ 5cm

         11. Evidence of neuroendocrine or small cell differentiation on prior biopsy

         12. History of severe hypersensitivity reactions to docetaxel or to drugs formulated with
             polysorbate 80