Inclusion Criteria:

          1. Male/female patients with histologically confirmed invasive HER2-positive (by American
             Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines)
             unilateral breast cancer

          2. Have previously untreated non-metastaic (M0), cT2-4N0 or cT1-4N1-3 (biopsies of
             clinically suspicious lymph nodes to confirm nodal status is encouraged).

          3. Multifocal/centric disease is permitted if all suspicious foci have been biopsied and
             are consistent with HER2-positive (by ASCO/CAP guidelines) invasive breast cancer

          4. Be a male or female subject 18 years of age on the day of signing informed consent

          5. Male Participants: A male participant must agree to use a contraception as detailed in
             Appendix C of this protocol during the treatment period and for at least 6 months
             after the last dose of study treatment and refrain from donating sperm during this
             period.

          6. Female Participants: A female participant is eligible to participate if she is not
             pregnant (see Appendix C), not breastfeeding, and at least one of the following
             conditions applies: a.) Not a woman of childbearing potential (WOCBP) as defined in
             Appendix C OR b.) A WOCBP who agrees to follow the contraceptive guidance in Appendix
             C during the treatment period and for at least 6 months after the last dose of study
             treatment.

          7. The participant (or legally acceptable representative if applicable) provides written
             informed consent for the trial.

          8. Provides adequate archival tumor tissue sample or newly obtained core or excisional
             biopsy of a tumor lesion not previously irradiated. Formalin-fixed, paraffin embedded
             (FFPE) tissue blocks are preferred to slides. Newly obtained biopsies are preferred to
             archived tissue. Note: If submitting unstained cut slides, newly cut slides should be
             submitted to the testing laboratory within 14 days from the date slides are cut.

          9. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1.

         10. Have adequate organ function as defined by the following parameters. Specimens must be
             collected within 7 days prior to the start of study treatment.

               -  Absolute neutrophil count (ANC) ≥1500/µL

               -  Platelets ≥100 000/µL

               -  Hemoglobin ≥9.0 g/dL or ≥5.6 mmol/La

               -  Renal Creatinine (≤1.5 × ULN OR) OR Measured or calculated(b) creatinine
                  clearance (≥30 mL/min for participant with creatinine levels) (GFR can also be
                  used in place of creatinine or CrCl) (>1.5 × institutional ULN)

               -  Hepatic Total bilirubin ≤1.5 ×ULN OR direct bilirubin ≤ULN for participants with
                  total bilirubin levels >1.5 × ULN aspartate aminotransferase (AST, SGOT) and
                  alanine aminotransferase (ALT, SGPT) ≤2.5 × ULN (≤5 × ULN for participants with
                  liver metastases)

               -  Coagulation International normalized ratio (INR) OR prothrombin time (PT)
                  Activated partial thromboplastin time (aPTT) ≤1.5 × ULN unless participant is
                  receiving anticoagulant therapy as long as PT or aPTT is within therapeutic range
                  of intended use of anticoagulants

               -  Cardiac Echocardiogram or MUGA (multigated radionuclide angiography) Baseline
                  LVEF ≥ 55%

        Exclusion Criteria:

          1. A WOCBP who has a positive urine pregnancy test within 72 hours prior to
             randomization. If the urine test is positive or cannot be confirmed as negative, a
             serum pregnancy test will be required. Note: in the event that 72 hours have elapsed
             between the screening pregnancy test and the first dose of study treatment, another
             pregnancy test (urine or serum) must be performed and must be negative in order for
             subject to start receiving study medication.

          2. Has received prior therapy with an anti-PD-1 (programmed death protein 1), anti-PD-L1
             (Programmed death-ligand 1), or anti PD L2 (Programmed death-ligand 2) agent or with
             an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g.,
             CTLA-4, OX 40, CD137).

          3. Has received prior systemic anti-cancer therapy including investigational agents
             within 4 weeks prior to randomization. Note: If participant received major surgery,
             they must have recovered adequately from the toxicity and/or complications from the
             intervention prior to starting study treatment.

          4. Has received prior radiotherapy within 2 weeks of start of study treatment.
             Participants must have recovered from all radiation-related toxicities, not require
             corticosteroids, and not have had radiation pneumonitis.

          5. Has received a live vaccine within 30 days prior to the first dose of study drug.
             Examples of live vaccines include, but are not limited to, the following: measles,
             mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus
             Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection
             are generally killed virus vaccines and are allowed; however, intranasal influenza
             vaccines (eg, FluMist®) are live attenuated vaccines and are not allowed.

          6. Is currently participating in or has participated in a study of an investigational
             agent or has used an investigational device within 4 weeks prior to the first dose of
             study treatment.

             Note: Participants who have entered the follow-up phase of an investigational study
             may participate as long as it has been 4 weeks after the last dose of the previous
             investigational agent.

          7. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
             (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
             immunosuppressive therapy within 7 days prior to the first dose of study drug.

          8. Has a known additional malignancy that is progressing or has required active systemic
             treatment within the past 3 years. Note: Participants with basal cell carcinoma of the
             skin, squamous cell carcinoma of the skin, or carcinoma in situ (e.g. breast
             carcinoma, cervical cancer in situ) that have undergone potentially curative therapy
             are not excluded.

          9. Has active autoimmune disease that has required systemic treatment in the past 2 years
             (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
             drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid
             replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
             form of systemic treatment.

         10. Has a history of (non-infectious) pneumonitis that required steroids or has current
             pneumonitis.

         11. Has an active infection requiring systemic therapy.

         12. Has a known history of Human Immunodeficiency Virus (HIV).

         13. Has a known active Hepatitis B (defined as Hepatitis B surface antigen [HBsAg]
             reactive) or Hepatitis C virus (i.d. HCV RNA [qualitative] is detected) infection.

         14. Has a known history of active TB (Bacillus Tuberculosis).

         15. Has a history or current evidence of any condition, therapy, or laboratory abnormality
             that might confound the results of the study, interfere with the subject's
             participation for the full duration of the study, or is not in the best interest of
             the subject to participate, in the opinion of the treating investigator.

         16. Has known psychiatric or substance abuse disorders that would interfere with
             cooperation with the requirements of the trial.

         17. Is pregnant or breastfeeding, or expecting to conceive or father children within the
             projected duration of the study, starting with the screening visit through 120 days
             after the last dose of trial treatment.

         18. Has significant cardiovascular disease, such as:

               -  History of myocardial infarction, acute coronary syndrome or coronary
                  angioplasty/stenting/bypass grafting within the last 6 months

               -  Congestive heart failure (CHF) New York Heart Association (NYHA) Class II-IV or
                  history of CHF NYHA class III or IV

               -  Angina pectoris requiring anti-anginal medication, uncontrolled arrhythmias, or
                  uncontrolled hypertension (systolic blood pressure > 180mmHg and/or diastolic
                  blood pressure > 100mmHg).