Inclusion Criteria:

          -  Histological or cytological diagnosis of HCC or clinical diagnosis of HCC in cirrhotic
             patients by CT or MRI per the AASLD 2018 or EASL 2018 guidelines.

          -  The subject has disease that is not amenable to a curative treatment approach (eg,
             transplant, surgery, ablation therapy) or locoregional therapy (eg, TACE).

          -  Measurable disease per RECIST 1.1 as determined by the Investigator.

          -  Barcelona Clinic Liver Cancer (BCLC) stage Category B or C.

          -  Child-Pugh Score of A.

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

        Exclusion Criteria:

          -  Known fibrolamellar carcinoma, sarcomatoid HCC or mixed hepatocellular
             cholangiocarcinoma.

          -  Prior systemic anticancer therapy for advanced HCC including but not limited to
             chemotherapy, small molecule kinase inhibitors, and immune checkpoint inhibitors
             (ICIs). Subjects who have received local intratumoral or arterial chemotherapy are
             eligible; local anticancer therapy must be completed ≥ 28 days before randomization

          -  Radiation therapy for bone metastasis within 2 weeks, any other radiation therapy
             within 8 weeks prior to randomization.

          -  Known brain metastases or cranial epidural disease unless adequately treated with
             radiotherapy and/or surgery (including radiosurgery) and stable for at least 8 weeks
             prior to randomization.

          -  Concomitant anticoagulation with oral anticoagulants