Inclusion Criteria:

          -  Participant must have relapsed/refractory AML and exhausted standard available
             therapies known to provide clinical benefit.

          -  Subjects must be greater than or equal to 18 years of age.

          -  Subjects must have Eastern Cooperative Oncology Group (ECOG) performance status less
             than or equal to (≤) 2

          -  Women of childbearing potential must be willing to practice a highly-effective method
             of birth control for up to 50 days after the last dose of study drug.

          -  A man who is sexually active with a woman of childbearing potential and has not had a
             vasectomy must agree to use a barrier method of birth control during the study and for
             up to 50 days after the last dose of study drug.

          -  Subjects must be willing to participate to the study, have the ability to understand
             and adhere to study visit schedule and other protocol procedures, and be able and
             willing to sign a written informed consent form.

        Exclusion Criteria:

        Medical history:

          -  Women who are or plan to become pregnant, or who are currently breastfeeding.

          -  Persistence of any clinically relevant (Common Terminology Criteria for Adverse Events
             [CTCAE] Grade 2 or above) toxicities from previous therapy.

          -  Active alcohol or drug abuse.

          -  Previous drug-induced liver injury.

        Cardiac assessments:

          -  Uncontrolled congestive heart failure, unstable angina pectoris.

          -  History or current evidence of a myocardial infarction during the last 6 months.

          -  QTc prolongation greater than (>) 500 milliseconds (msec) (Fridericia formula).

          -  Congenitally long QT syndrome or has received any marketed or experimental compound in
             the last 4 weeks or 5 half-lives (whichever is shorter) prior to entering the study
             with possible or known effects of QT prolongation. (If equivalent medication is not
             available, QTc will be closely monitored.)

        Laboratory assessments:

          -  Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) greater than or
             equal to (≥) 1 * upper limit of normal (ULN).

          -  Serum bilirubin ≥ 1 * ULN (except those known to have Gilbert's syndrome).

          -  Creatinine clearance ≤45 milliliters per minute (mL/min) (estimated by Cockcroft-Gault
             or by 24-hour urine collection).

          -  Any laboratory abnormality, which in the opinion of the investigator, places the
             participant at an unacceptably high risk for toxicities.

        Gastrointestinal (GI) assessments:

          -  Liver malignancy (including metastases) or chronic liver disease.

          -  History of Gastrointestinal surgery or procedures or conditions that might interfere
             with the absorption or swallowing of the study drug.

        Immunologic:

          -  Known hypersensitivity to study drug or its excipients.

        Miscellaneous:

          -  Any sign of active uncontrolled infections; any severe chronic disease potentially
             interfering with the protocol, including human immunodeficiency virus (HIV) infection,
             or active hepatitis B or C or those with a positive screen for hepatitis A
             Immunoglobulin M (IgM).

          -  Any other malignancies within the past 2 years other than basal cell skin cancer or
             carcinoma in situ of the cervix.

          -  Participant concomitantly receiving any other investigational agents.

          -  Systemic chemotherapy within 2 weeks or investigational therapy within 5 half-lives
             prior to first dose of study drug, unless there is evidence of rapidly progressive
             disease (in which case the shorter washout of 2 weeks will be followed). For
             monoclonal antibodies, the washout from prior therapy will be 4 weeks, unless there is
             evidence of rapidly progressive disease, in which case, the shorter washout period of
             2 weeks will be followed. Persistent chronic clinically significant toxicities from
             prior chemotherapy must not be >Grade 1. Use of hydroxyurea (Hydrea) is permitted up
             to 24 hours prior to start of study drug for control of proliferative disease. Hydrea
             treatment may be reinstated during study for control of proliferative disease, as
             needed, at the discretion of investigator.

          -  Participants with AML that has advanced with central nervous system (CNS) involvement.

          -  Participant is pregnant or breastfeeding or expecting to conceive or father children
             within the projected duration of the study.

          -  Participants receiving CYP2B6 substrates such as bupropion and methadone.

          -  Participants receiving strong CYP3A4 inducers such as carbamazepine, enzalutamide,
             mitotane, phenytoin, rifampin, and St. John's wort (hypericin) or drugs that are
             exclusively substrates of CYP3A4.

          -  Participant is receiving moderate or strong CYP3A4 inhibitors. (Note: This exclusion
             criterion is not applicable to subjects participating in sub-study where only subjects
             who are currently on/require antifungals [prophylaxis/treatment] will be enrolled)