Inclusion criteria:

          -  Patients must be ≥18 years of age (≥20 years of age in Japan). All genders are
             permitted.

          -  Histologically or cytologically confirmed locally advanced or metastatic EGFRm+ NSCLC
             harbouring an EGFR mutation known to be associated with EGFR TKI sensitivity and
             permitted in the osimertinib national label (such as either exon 19 deletion and/or
             L858R) which is not amenable to curative therapy.

          -  Documented radiologic disease progression on first line osimertinib.

          -  MET-amplification as determined by FISH (central) testing on tumour sample collected
             following progression on 1L osimertinib treatment.

          -  Available tumour sample for central MET FISH and IHC analysis or willingness to
             collect additional sample for central testing which fulfils the following
             requirements:

        Obtained following progression on previous osimertinib therapy;

        obtained within 2 years of submission for MET analysis;

        sufficient tissue to meet the minimum tissue requirement defined in the current Laboratory
        Manual.

          -  At least 1 lesion, not previously irradiated, not biopsied during the screening
             period, that can be accurately measured at baseline as ≥10 mm in the longest diameter
             (except lymph nodes which must have short axis ≥15 mm) with CT or MRI which is
             suitable for accurate repeated measurements. If only 1 measurable lesion exists, it is
             acceptable to be used as long as baseline tumour assessment scans are done at least 14
             days after the screening tumour sample collection is performed.

          -  Prior lines of therapy in locally advanced/metastatic setting: Only prior 1L
             osimertinib treatment in metastatic setting is permitted.

          -  Adequate haematological function defined as:

          -  Absolute neutrophil count ≥1500/μL

          -  Haemoglobin ≥9 g/dL (no transfusion in the past 2 weeks)

          -  Platelets ≥100,000/μL (no transfusion in the past 10 days)

          -  Adequate liver function

          -  ALT, AST ≤2.5 x ULN with TBL ≤ ULN OR

          -  TBL >ULN to ≤1.5x ULN with ALT and AST ≤ ULN

          -  Adequate renal function - defined as a serum creatinine <1.5 times the institutional
             ULN OR a glomerular filtration rate ≥50 mL/min. Confirmation of creatinine clearance
             is only required when creatinine is only required when creatinine is >1.5 times ULN.

          -  Adequate coagulation parameters: INR <1.5 x ULN and activated partial thromboplastin
             time <1.5 x ULN unless patients are receiving therapeutic anti coagulation which
             affects these parameters.

          -  Patients with known tumour thrombus or deep vein thrombosis are eligible if clinically
             stable on low molecular weight heparin for ≥2 weeks.

          -  ECOG/WHO performance status of 0 or 1 with no deterioration over the previous 2 weeks
             and a minimum life expectancy of 12 weeks.

          -  Females must be using highly effective contraceptive measures, should not be breast
             feeding and must have a negative pregnancy test if of childbearing potential, or must
             have evidence of non-childbearing potential.

          -  Males with a female partner of childbearing potential should be willing to use barrier
             contraception during the study and for 6 months following discontinuation of study
             drug.

        Exclusion Criteria:

          -  Unresolved toxicities from any prior therapy greater than Common Terminology Criteria
             for Adverse Events (CTCAE) Grade 1 at the time of starting study treatment with the
             exception of alopecia and Grade 2 prior platinum therapy related neuropathy.

          -  As judged by the investigator, active gastrointestinal disease or other condition that
             will interfere significantly with the absorption, distribution, metabolism, or
             excretion of oral therapy (eg, ulcerative disease, uncontrolled nausea, vomiting,
             diarrhoea Grade ≥2, malabsorption syndrome or previous significant bowel resection).

          -  Any of the following cardiac diseases currently or within the last 6 months:

        Unstable angina pectoris

        Congestive heart failure (New York Heart Association [NYHA] ≥Grade 2)

        Acute myocardial infarction

        Stroke or transient ischemic attack

        Uncontrolled hypertension (BP ≥150/95 mmHg despite medical therapy).

        Mean resting correct QT interval (QTcF) >470 msec for women and >450 msec for men at
        Screening, obtained from 3 ECGs using the screening clinic ECG machine derived QTcF value.

        Any factors that may increase the risk of QTcF prolongation or risk of arrhythmic events
        such as heart failure, chronic hypokalaemia not correctable with supplements, congenital or
        familial long QT syndrome, family history of unexplained sudden death under 40 years of age
        in first-degree relatives or any concomitant medication known to prolong the QT interval
        and cause Torsade de Pointes.

        Any clinically important abnormalities in rhythm, conduction or morphology of resting ECGs,
        eg, complete left bundle branch block, third degree heart block, second degree heart block,
        P-R interval >250 msec.

        Acute coronary syndrome

          -  Wide field radiotherapy (including therapeutic radioisotopes such as strontium 89)
             administered ≤28 days or limited field radiation for palliation ≤7 days prior to
             starting study drug or has not recovered from side effects of such therapy.

          -  Major surgical procedures ≤28 days of beginning study drug or minor surgical
             procedures ≤7 days

          -  Evidence of severe or uncontrolled systemic diseases, including renal transplant,
             active bleeding diatheses or uncontrolled hypertension, which in the investigator's
             opinion makes it undesirable for the patient to participate

          -  Active hepatitis B or C or known serious active infection e.g. tuberculosis or human
             immunodeficiency virus. Viral testing is not required for assessment of eligibility
             for the study.

          -  Presence of other active cancers, or history of treatment for invasive cancer, within
             the last 5 years. Patients with Stage I cancer who have received definitive local
             treatment at least 3 years previously, and are considered unlikely to recur are
             eligible. All patients with previously treated in situ carcinoma (ie, non-invasive)
             are eligible, as are patients with history of non-melanoma skin cancer.

          -  Spinal cord compression or brain metastases unless asymptomatic, stable and not
             requiring steroids for at least 2 weeks prior to start of study treatment.

          -  Past medical history of interstitial lung disease(ILD), drug-induced ILD, radiation
             pneumonitis which required steroid treatment, or any evidence of clinically active
             ILD.

          -  Prior or current treatment with a 3rd generation EGFR-TKI other than osimertinib.

          -  Prior or current treatment with savolitinib or another MET inhibitor (eg, foretinib,
             crizotinib, cabozantinib, onartuzumab, capmatinib).

          -  Any cytotoxic chemotherapy, investigational agents or other anticancer drugs for the
             treatment of advanced NSCLC from a previous treatment regimen or clinical study within
             14 days prior to the first dose of study treatment with the exception of monotherapy
             osimertinib which may continue uninterrupted during screening.

          -  Patients currently receiving (or unable to stop use prior to receiving the first dose
             of study treatment) medications or herbal supplements known to be strong inducers of
             CYP3A4, strong inhibitors of CYP1A2 within 2 weeks of the first dose of study
             treatment (3 weeks for St John's Wort).

          -  Participation in another clinical study with a cytotoxic, investigational product
             (IP), or other anticancer drug for the treatment of advanced NSCLC if received IP from
             that study within 14 days of the first dose of study treatment.

          -  Known hypersensitivity to the active or inactive excipients of osimertinib or
             savolitinib or drugs with a similar chemical structure or class.