This trial will consist of 3 parts; Phase 1 Maximum Tolerated Dose, Phase 1 extended cohort
and Phase 2a.
For Phase 1, those who have a confirmed diagnosis of relapsed/refractory Non-Hodgkin's
Lymphoma (NHL) of B-cell Origin of any subtype will be considered eligible for enrolment.
Each cycle last approximately 28 days.
Once the dose of MG4101 is determined from Phase 1, Phase 2a will commence whereby two
subgroups of patients will be enrolled and will similarly receive up to 6 cycles of treatment
with the recommended Phase 2a dose of MG4101. The 2 subgroups are patients with indolent and
aggressive NHL of B-cell origin respectively.
Inclusion Criteria:
1. Patients with relapsed or refractory NHL of B-cell origin (mature B cell lymphoma
according to WHO)* who are not considered candidates for intensive anti-lymphoma
therapy.
2. Patients must have received at least 1 prior systemic treatment including anti-CD20
therapy but have received no more than 4 systemic treatments and have:
1. Relapse/Progression and is not considered as a candidate for autologous stem-cell
transplantation or high-dose immuno-chemotherapy with allogenic antibody
transplantation.
2. Or Relapsed/progressed after high-dose immuno-chemotherapy with autologous
stem-cell transplantation.
3. Or Relapsed/progressed after homoplastic stem-cell transplantation performed at
least 12 weeks ago from C1V1.
- For Phase 1 - Any subtype can be enrolled. For Phase 2a - Only below subtype
can be enrolled in each group. I. Indolent B-cell NHL: Follicular Lymphoma,
Lymphoplasmacytic Lymphoma, Mantle Cell Lymphoma and Marginal Zone Lymphoma
II. Aggressive B-cell NHL: Diffuse Large B-cell Lymphoma De novo and Diffuse
Large B-cell Lymphoma transformed
3. According to Positron Emission Tomograph(PET)-CT screening, patients having
lesion/nodules ≥1 with major axis longer than 1.5 cm and the boundaries are clearly
shown.
4. Eastern Cooperative Oncology Group score 0 or 1
5. 20 years or older. Age limit for Phase 1 is 65 and for Phase 2a 80.
6. Expected lifespan ≥ 3 month
7. Patients signed Informed consent form
8. Earlier documented result that showed that the patient is positive for CD20 via
immunophenotyping within 6 months of C1V1
9. Toxicities due to prior therapy must be stable and recovered to ≤ Grade 1 (except for
clinically non-significant toxicities such as alopecia)
10. Those patients who satisfied with following criteria in blood testing, kidney function
test and liver function test:
1. Absolute neutrophil count: Absolute Neutrophil Count ≥ 1,000/ µL (Growth factor
support at least 2 weeks prior to C1V1)
2. Haemoglobin level ≥ 8g/㎗ (Blood transfusion at least 2 weeks prior to C1V1)
3. Platelet count ≥75,000/µL (Growth factor support/blood transfusion at least 2
weeks prior to C1V1)
4. Total bilirubin < 3.0㎎/㎗
5. Aspartate aminotransferase(AST) or Alanine Aminotransferase(ALT) ≤ 2.5 x upper
normal limit (UNL)
6. Creatinine clearance (as estimated by Cockcroft Gault) ≥ 30 mL/min
Exclusion Criteria:
1. Patients considered appropriate to have stem-cell transplantation after high-dose
chemotherapy as salvage therapy.
2. Patient with Central Nervous System(CNS) lymphoma or any involvement of the CNS.
3. Patients who had a prior history of another malignancy over the last 5 years.
4. Patients with impaired organ functions deemed as significant by investigators.
5. Patients who had prior allogeneic Natural Killer cell treatment.
6. Chronic or active infectious diseases required to be treated at the time of
Investigational Product administration, including Cytomegalovirus(CMV) prophylactic
therapy.
7. Had human immunodeficiency virus (HIV)-positive serology.
8. HBsAg or Hepatitis B virus(HBV) DNA positive or had Hepatitis C virus(HCV) antibodies
9. Patients who received anti-CD20 cancer chemotherapy or immunoglobulin within 4 weeks
of C1V1.
10. Patients who received another investigational drug within 4 weeks of C1V1.
11. Patients with acute graft-versus-host disease(GvHD) ≥Grade 3 or extensive chronic GvHD
within 2 weeks of C1V1.
12. High-dose stem cell support treatment carried out within 6 months of C1V1.
13. Radioimmunotherapy within 4 weeks of C1V1.
14. Patients with major surgery within 4 weeks of C1V1.
15. Patients required to have treatment as having severe diseases such as severe heart
failure or uncontrolled severe heart disease and considered not to be appropriate to
participate in this trial by investigator's decision.
16. Patients on enzyme inducing agents.
17. Patients who have a plan to have vaccination during the trial.
18. Patients with sensitivity to Interleukin-2, cyclophosphamide or fludarabine.
19. Patients with urinary outflow obstruction
20. Patients with history of abnormal cardiac or pulmonary function tests in 6 months
prior to screening visit (Clinically Significant)
21. Patients with history of solid organ allografts
22. Patients with pre-existing or initial presentation of autoimmune disease or
inflammatory disorders, such as Crohn's disease, scleroderma, thyroiditis,
inflammatory arthritis, diabetes mellitus, oculo-bulbar myasthenia gravis, crescentic
Immunoglobulin A(IgA) glomerulonephritis, cholecystitis, cerebral vasculitis,
Stevens-Johnson syndrome and bullous pemphigoid, due to possible exacerbation with
IL-2
23. Concomitant treatment with other cardiotoxic inducing agents
24. Patients who are allergic to Rituximab, Rituximab's excipient (sodium citrate,
polysorbate 80, sodium chloride, sodium hydroxide, hydrochloric acid) or other
proteins same as Rituximab.
25. From the day of participation of this trial to 12 months from the day of final
administration of Investigational Product, patients who are unable or unwilling to use
appropriate contraceptive methods. (Condom, diaphragm, Intrauterine Device, hormonal
oral contraceptive use, or male partner with vasectomy)
26. Pregnant or lactating women. (Breast-feeding cannot be done within 12 months after
final Investigational Product administration)
27. Patients suspected to have currently known or suspected alcohol abuse or drug abuse
according to investigator's decision.
28. According to investigator's judgement, protocols cannot be followed.
