The purpose of this research study is to evaluate safety, pharmacokinetics, pharmacodynamics
and preliminary efficacy of the investigational drug PLX2853 in subjects with Relapsed or
Refractory Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome
Inclusion Criteria:
1. Confirmed diagnosis of one of the following myeloid malignancies, based on the 2016
revision of the World Health Organization classification:
A. Relapsed or refractory AML.
I. Subjects must have received no more than 3 prior induction therapies and have no
standard therapeutic option that is expected to result in a clinical benefit.
B. Relapsed or refractory MDS.
I. Subjects must have high-risk disease (intermediate or greater disease according to
the revised International Prognostic Scoring System [IPSS-R]).
II. Subjects must have received no more than 3 prior therapies, 1 of which must have
included a hypomethylating agent such as azacytidine or decitabine.
III. Subjects must have no standard therapeutic option that is expected to result in a
clinical benefit.
2. Age ≥18 years.
3. Eastern Cooperative Oncology Group (ECOG) performance status of ≤2.
4. Life expectancy of ≥3 months in the judgment of the investigator.
5. Adequate renal, hepatic, and coagulation parameters:
A. Measured or calculated (Cockcroft-Gault formula) creatinine clearance (CrCl) ≥60
mL/min.
B. Total bilirubin ≤1.5 × ULN unless due to Gilbert's syndrome.
C. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5 × ULN.
D. Prothrombin time or international normalized ratio ≤1.5 × ULN.
E. Activated partial thromboplastin time ≤1.5 × ULN.
6. Women of child-bearing potential must have a negative pregnancy test at Screening and
must agree to use an effective form of contraception from the time of the negative
pregnancy test to 90 days after the last dose of study drug. Effective forms of
contraception include abstinence, hormonal contraception in conjunction with a barrier
method, or a double barrier method. Women of non-child-bearing potential may be
included if they are either surgically sterile or have been postmenopausal for ≥ 1
year.
7. Fertile men must agree to use an effective method of birth control during the study
and for 90 days after the last dose of study drug.
8. Resolution (to ≤Grade 1 or baseline) of all significant toxicity associated with prior
cancer therapy prior to study drug initiation. (Grade 2 alopecia or residual Grade 2
peripheral neuropathy is allowed.)
9. Willingness and ability to provide written informed consent prior to any study-related
procedures and to comply with all study requirements.
Exclusion Criteria:
1. Prior treatment with a bromodomain inhibitor.
2. Any one of the following therapies:
A. Stem cell transplantation within 90 days of study drug initiation;
B. Active immunosuppressive therapy for graft-versus-host disease (GVHD);
C. GVHD prophylaxis within 2 weeks of study drug initiation.
3. Known uncontrolled fungal, bacterial, and/or viral infection ≥Grade 2.
4. Uncontrolled autoimmune hemolytic anemia or immune thrombocytopenia.
5. Active symptomatic central nervous system involvement of AML. (Individuals who have
had leptomeningeal disease that was effectively treated are eligible.)
6. A diagnosis of acute promyelocytic leukemia or chronic myeloid leukemia in blast
crisis.
7. Known or suspected allergy to the study drug or any agent given in association with
this trial.
8. Women who are either pregnant or breast feeding.
9. Clinically significant cardiac disease.
10. Inability to take oral medication or significant nausea and vomiting, malabsorption,
or significant small bowel resection that, in the opinion of the Investigator, would
preclude adequate absorption.
11. Individuals who are known to be infected with HIV, hepatitis B virus (HBV), or
hepatitis C virus (HCV) or are known carriers of HBV or HCV. Individuals who are
positive for HCV antibody must be negative for HCV RNA by polymerase chain reaction
(PCR) to be eligible. Individuals with occult or prior HBV infection (defined as being
seropositive for total hepatitis B core antibody and seronegative for hepatitis B
surface antigen) may be included if HBV DNA is undetectable. These individuals must be
willing to undergo additional testing per local standard of care.
12. Active second malignancy with the exception of any of the following:
- Adequately treated basal cell carcinoma, squamous cell carcinoma of the skin, or
in situ cervical cancer;
- Adequately treated Stage I cancer from which the subject is currently in
remission and has been in remission for ≥2 years;
- Low-risk prostate cancer with Gleason score <7 and prostate-specific antigen <10
ng/mL;
- Any other cancer from which the patient has been disease-free for ≥3 years.
13. Major surgery or significant injury within the 14-day period prior to study drug
initiation.
14. Anti-cancer therapy in the period immediately preceding study drug initiation.
15. Any other medical, psychological, familial, sociologic, or geographic condition that,
in the judgement of the investigator, would potentially hamper compliance with the
study protocol or interfere with the study endpoints or the subject's ability to
participate in the study.
16. Participation in any other therapeutic clinical study. (Participation in observational
or registry trials is allowed.)
17. Individuals who are on active anticoagulation therapy (e.g., warfarin, factor Xa
inhibitors, thrombin inhibitors, heparin).
