Inclusion Criteria:

          1. Provision of informed consent prior to any study specific procedures

          2. Male ages 18 years and older at time of signing the informed consent form

          3. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 within 42 days
             prior to registration

          4. Histologic or cytologic proof of prostate adenocarcinoma (excluding small-cell or
             neuroendocrine pathologies)

          5. Metastatic prostate cancer on CT, MRI or Bone scan

          6. Must have disease progression (while testosterone level is under 50 ng/dl) on prior
             therapy prior to study entry defined as one (or more) of the following:

               1. PSA progression defined as continuously rising PSA values measured a minimum of 1
                  week apart with a minimal starting value of 1.0 ng/mL

               2. Progression of bidimensionally measurable soft tissue or nodal metastasis by CT
                  or MRI based on RECIST, v1.1

          7. Prior treatment with at least one of the following:

               1. One line of therapy in mCRPC

               2. Second generation anti-androgen (e.g. abiraterone, enzalutamide or apalutamide)
                  within the hormone-sensitive phase of disease AND progression occurs while on
                  therapy

          8. Patients must be withdrawn from prior therapy for ≥3 weeks (patients may remain on
             prior prednisone up to 10 mg total daily exposure at provider's discretion) at planned
             time of treatment start.

          9. Agree to undergo a biopsy of at least one metastatic site (if feasible) to determine
             DNA repair status, unless prior metastatic tissue underwent next-generation sequencing
             in a CLIA certified lab or known germline loss of BRCA1, BRCA2 or ATM. If no site is
             reachable, or first biopsy insufficient/unsuccessful, circulating tumor DNA may be
             obtained.

         10. Treated with continuous androgen deprivation therapy (either surgical castration or
             LHRH agonist/antagonist) with documented castrate level of serum testosterone (<50
             ng/dL). A stable dose of bisphosphonate or denosumab for bone metastases should be
             continued as long as started at least 5 days prior to C1D1 planned start day.

         11. At the time of planned treatment start (C1D1), at least 21 or more days will have
             elapsed from palliative radiation (with the exception of radiation to >30% of bone
             marrow or with a wide field of radiation, this requires 28 or more days).

         12. Patient must have normal organ and bone marrow function measured within 42 days prior
             to registration as defined below

               1. Hemoglobin ≥10 g/dL (with no blood transfusion or erythropoietin use within the
                  past 42 days)

               2. Absolute neutrophil count ≥1.5x109/L

               3. Platelet count ≥100x109/L (with no platelet transfusions within last 42 days)

               4. Total bilirubin <1.5x ULN (unless the patient has documented Gilbert's disease
                  and <2.0x ULN should be used)

               5. AST or ALT ≤ 2.5x ULN, unless liver metastases are present in which case they
                  cannot be ≥5x ULN

               6. Glomerular filtration rate (GFR) ≥51 mL/min, as assessed using the Cockcroft-
                  Gault equation

         13. Estimated life expectancy ≥16 weeks

         14. Male patients who are sexually active must be willing to use barrier contraception for
             the duration of the study and for 1 week after the last study drug administration,
             with all sexual partners. Male patients must use a condom during treatment and for 6
             months after the last dose of study drug(s) when having sexual intercourse with a
             pregnant woman or with a woman of childbearing potential and must not donate sperm for
             6 months after the last dose of study drug. Female partners of male patients should
             also use a highly effective form of contraception (per protocol) for 6 months after
             the last dose of study drug(s) if they are of childbearing potential. True abstinence
             is an acceptable form of contraception and must be documented as such.

         15. Patient is willing and able to comply with the protocol for the duration of the study,
             including undergoing biopsy (if warranted), treatment, scheduled visits and
             examinations

        Exclusion Criteria:

          1. A diagnosis of ataxia telangiectasia

          2. Prior treatment with a PARP inhibitor (e.g. olaparib, veliparib, niraparib,
             rucaparib), AZD6738 or other DNA-damage response agents (e.g. cisplatin or
             carboplatin)

          3. Cytotoxic chemotherapy, first- or second-generation antiandrogen or CYP17 inhibitors
             are not permitted within 21 days or 5 half-lives of registration (whichever is
             longest) of planned treatment start. For clarity, enzalutamide requires 5 weeks
             washout.

          4. Major surgery < 2 weeks prior to enrolment; patients must have recovered from any
             effects of major surgery

          5. Persistent toxicities (≥CTCAE Grade 2) caused by previous cancer therapy, besides
             Grade 2 alopecia and Grade 2 neuropathy (these are allowed).

          6. Patients with current or prior MDS/AML or with features suggestive of MDS/AML

          7. Any other malignancy which has been active or treated within the past 3 years, with
             the exception of non-melanomatous skin cancer, or Ta bladder cancer

          8. Patients with active brain metastases are excluded because of unknown penetration into
             the CNS. A confirmatory scan for asymptomatic patients is not required. Patients with
             a history of treated central nervous system (CNS) metastases are eligible provided
             they meet all of the following criteria: disease outside the CNS is present, no
             clinical evidence of progression since completion of CNS-directed therapy, minimum 3
             weeks between completion of radiotherapy and registration and recovery from
             significant (Grade ≥ 3) acute toxicity with no ongoing requirement for >10 mg of
             prednisone per day or an equivalent dose of other corticosteroid. If a patient must
             remain on steroids, they must have started the steady dose at least 28 days prior to
             treatment. Patients with spinal cord compression unless considered to have received
             definitive treatment for this and evidence of clinically stable disease for 28 days
             prior to study treatment.

          9. Any of the following cardiac disease currently or within the last 6 months:

               1. Unstable angina pectoris

               2. Congestive heart failure (by New York Heart Association ≥ Class 2) or known
                  reduced LVEF < 55%

               3. Acute myocardial infarction

               4. Conduction abnormality not controlled with pacemaker or medication (e.g. complete
                  left bundle branch block or third-degree heart block)

               5. Significant ventricular or supraventricular arrhythmias (patients with chronic
                  rate-controlled atrial fibrillation in the absence of other cardiac abnormalities
                  are eligible).

               6. Uncontrolled hypertension (Grade 2 or above) requiring urgent (for example,
                  adjusting medications within 24 hours) clinical intervention

               7. Patients at risk of brain perfusion problems, e.g. TIAs or history of pre-
                  syncope or syncopal episodes unexplained by reversible causes

         10. Mean resting corrected QT interval >450, obtained from 3 ECGs 2-5 minutes apart using
             the Fredericia formula. Absence of any factors that increase the risk of QTc
             prolongation or risk of arrhythmic such as congenital long QT syndrome, immediate
             family history of long QT syndrome or unexplained sudden death under 40 year of age.
             Patients with relative hypotension (<90/60 mmHg) or previously known clinically
             relevant orthostatic hypotension defined as a postural hypotension ≥20 mmHg

         11. Concomitant use of known potent or moderate cytochrome P (CYP) 3A inhibitors (e.g.
             itraconazole, ciprofloxacin, diltiazem) require 2-week washout prior to planned C1D1.
             Concomitant use of strong or moderate CYP3A inducers (e.g. phenobarbital,
             enzalutamide, modafinil require 5-week washout for enzalutamide or phenobarbital and 3
             week washout for all others, per protocol.

         12. As judged by the Investigator, any evidence of severe or uncontrolled systemic
             diseases that places the patient at unacceptable risk of toxicity or non-compliance.
             Examples include, but are not limited to, active bleeding diatheses, renal transplant,
             uncontrolled major seizure disorder, severe COPD, superior vena cava syndrome,
             extensive bilateral lung disease on High Resolution CT scan, severe Parkinson's
             disease, active inflammatory bowel disease, psychiatric condition, immunocompromised
             patients or active infection including any patient known to have hepatitis B,
             hepatitis C and human immunodeficiency virus (HIV) or requiring systemic antibiotics,
             antifungals or antiviral drugs. Screening for chronic conditions is not required

         13. A known hypersensitivity to olaparib, AZD6738 or any excipient of the product or any
             contraindication to the combination anti-cancer agent as per local prescribing
             information

         14. Patients unable to swallow orally administered medication and patients with
             gastrointestinal disorders likely to interfere with the absorption of the study
             medication, refractory nausea and vomiting, chronic gastrointestinal diseases or
             previous significant bowel resection, with clinically significant sequelae that would
             preclude adequate absorption of AZD6738

         15. Previous allogenic bone marrow transplant or double umbilical cord blood
             transplantation (dUCBT).

         16. Whole blood transfusions in the last 120 days prior to entry to the study (packed red
             blood cells and platelet transfusions are acceptable, for timing refer to inclusion
             criteria no.12)

         17. Involvement in the planning and/or conduct of the study

         18. Judgment by the investigator that the patient should not participate in the study if
             the patient is unlikely to comply with study procedures, restrictions and
             requirements.

         19. Previous enrolment in the present study.

         20. Has received a live vaccination with 2 weeks of enrollment.