The primary purpose of this study is to evaluate the tolerability and safety profile of
ASP1951 when administered as a single agent and in combination with pembrolizumab in
participants with locally advanced (unresectable) or metastatic solid tumors; characterize
the pharmacokinetic profile of ASP1951 when administered as a single agent and in combination
with pembrolizumab; and determine the recommended phase 2 dose (RP2D) of ASP1951 and/or
maximum tolerated dose (MTD) when administered as a single agent and in combination with
pembrolizumab. This study will also evaluate the anti-tumor effect of ASP1951 when
administered as a single agent and in combination with pembrolizumab.
This is a dose-escalation and expansion study of ASP1951. The study consists of 3 periods for
monotherapy and combination therapy: screening, treatment and follow up, followed by an
optional Re-treatment period for participants that qualify.
The monotherapy escalation cohorts will evaluate escalating dose levels of ASP1951 in
participants with locally advanced (unresectable) or metastatic solid tumor malignancies
including but not limited to squamous cell carcinoma of the head and neck (SCCHN), colorectal
cancer, metastatic castration-resistant prostate cancer (mCRPC) and cervical cancer.
The combination escalation cohorts will evaluate escalating dose levels of ASP1951 in
combination with a fixed dose of pembrolizumab.
For dose expansion, the tumor-specific cohorts will include participants with squamous cell
carcinoma of the head and neck (SCCHN), non-small cell lung cancer (NSCLC) (all PD-L1
status), NSCLC PDL1 high, and cervical cancer, as well as participants with any tumor types
that respond to study drug treatment during dose escalation.
Participants may reinitiate study drug treatment in the optional Re-treatment period after
confirmation that the participant meets all the re-treatment eligibility criteria.
After discontinuation of study drug, all participants will complete an end-of-treatment
visit, along with 30-day and 90 day safety follow-up visits from the last dose of study drug.
- Subject has locally-advanced (unresectable) or metastatic solid tumor malignancy (no
limit to the number of prior treatment regimens) that is confirmed by available
pathology records or current biopsy as well as the following:
- Subject in the escalation cohort has received all standard therapies (unless the
therapy is contraindicated or intolerable) felt to provide clinical benefit the
subject's specific tumor type. OR
- Subject in an expansion cohort has received at least 1 standard therapy for the
subject's specific tumor type.
[Taiwan only]: Subject has locally-advanced (unresectable) or metastatic solid tumor
malignancy (no limit to the number of prior treatment regimens) that is confirmed by
available pathology records or current biopsy and has received all standard therapies
(unless the therapy is contraindicated or intolerable) felt to provide clinical benefit in
the opinion of the treating investigator for his/her specific tumor type. Note: Subjects in
the combination expansion cohort with tumor types that pembrolizumab is not approved for
can only enroll if their standard treatment is ineffective, unsuitable per investigator's
judgment or if the subject is unwilling to receive the standard therapy.
- Subject has an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.
- Subject's last dose of prior antineoplastic therapy, including any immunotherapy, was
21 days or 5-half-lives, whichever is shorter, prior to initiation of study drug
administration. A subject with epidermal growth factor receptor (EGFR) or anaplastic
lymphoma kinase (ALK) mutation-positive NSCLC is allowed to remain on EGFR tyrosine
kinase inhibitor (TKI) or ALK inhibitor therapy until 4 days prior to the start of
study drug administration.
- Subject has completed any radiotherapy (including stereotactic radiosurgery) at least
2 weeks prior to study drug administration. Subjects must have recovered from all
radiation related toxicities, not require corticosteroids and not have had radiation
pneumonitis. A 1-week washout is permitted for palliative radiation (≤ 2 weeks of
radiotherapy) to noncentral nervous system [CNS] disease.
- Subject's AEs (excluding alopecia) from prior therapy have improved to grade 1 or
baseline within 2 weeks prior to start of study treatment.
- Subject with metastatic castration-resistant prostate cancer (mCRPC) (positive bone
scan and/or soft tissue disease documented by computed tomography [CT]/magnetic
resonance imaging [MRI]) meets both of the following:
- Subject has serum testosterone ≤ 50 ng/dL at Screening.
- Subject has had a bilateral orchiectomy or plans to continue androgen deprivation
therapy (ADT) for the duration of study treatment.
- Subject has adequate organ function prior to start of study treatment. If a subject
has received a recent blood transfusion, the laboratory tests must be obtained ≥ 4
weeks after any blood transfusion. Subjects can be on stable dose of erythropoietin (≥
approximately 3 months).
- A female subject is eligible to participate if she is not pregnant and at least 1 of
the following conditions applies:
- Not a woman of childbearing potential (WOCBP); OR
- WOCBP who agrees to follow the contraceptive guidance throughout the treatment
period and for at least 6 months after the final study drug administration.
- Female subject must agree not to breastfeed starting at Screening and throughout the
study treatment, and for 6 months after the final study drug administration.
- Female subject must not donate ova starting at Screening and throughout the study
treatment, and for 6 months after the final study drug administration.
- A male subject with female partner(s) of childbearing potential must agree to use
contraception during the treatment period and for at least 6 months after the final
study drug administration.
- A male subject must not donate sperm during the treatment period and for at least 6
months after the final study drug administration.
- Male subject with a pregnant or breastfeeding partner(s) must agree to remain
abstinent or use a condom for the duration of the pregnancy or time partner is
breastfeeding throughout the study period and for 6 months after the final study drug
- Subject agrees not to participate in another interventional study while receiving
study drug (Subjects who are currently in the follow-up period of an interventional
clinical trial are allowed).
Additional Inclusion Criteria for Subjects in the Expansion Cohorts:
- Subject has at least 1 measureable lesion per RECIST 1.1. Lesions situated in a
previously irradiated area are considered measurable if progression has been
demonstrated in such lesions. Subjects with mC RPC who do not have measurable lesions
must have at least 1 of the following:
- Progression with 2 or more new bone lesions; or
- Prostate-specific antigen (PSA) progression (defined as a minimum of 3 rising PSA
levels with an interval of ≥ 1 week between each determination) within 6 weeks
prior to study drug administration and a PSA value at the screening visit ≥ 2
- Subject consents to provide available tumor specimen in a tissue block or unstained
serial slides obtained within 56 days prior to first dose of study treatment. Note:
This does not apply to subjects with mCRPC who do not have measurable disease.
- Subject is an appropriate candidate for tumor biopsy and consents to undergoing a
tumor biopsy (core tissue biopsy or excision) during the treatment period as indicated
in the Schedule of Assessments. Note: This does not apply to subjects with mCRPC who
do not have measurable disease.
- Subject meets one of the following:
- Subject has the tumor type for which a confirmed response was observed in a
monotherapy or combination therapy cohort; or
- Subject has SCCHN and a combination therapy expansion cohort is opened due to
achieving the predicted efficacious exposure or
- High dose RP2D combination therapy expansion cohorts are opened and subject has
NSCLC (all PD-L1 status), NSCLC PD-L1 high*, SCCHN, or cervical cancer; or
- Low dose RP2D combination therapy expansion cohorts are opened and subject has
NSCLC (all PD-L1 status), SCCHN and cervical cancer.
- NSCLC with PD-L1 high expressing tumor (tumor proportion score ≥ 50%) as
determined by 22C3 PD-L1 immunohistochemistry assay at a local/central
laboratory during the screening period. Note: Local 22C3 PD-L1 IHC assay
results available within 60 days prior study drug administration may be used
for evaluating this entry criterion.
Additional Inclusion Criteria for Re-treatment:
- Subject stopped initial treatment with ASP1951 or ASP1951 in combination with
pembrolizumab after attaining a confirmed CR, PR or SD.
- Subject experienced an investigator-determined iCPD after stopping their initial
treatment with ASP1951 or ASP1951 in combination with pembrolizumab.
- Subject did not receive any prohibited anti-cancer treatment since the last dose of
ASP1951 or ASP1951 in combination with pembrolizumab.
- Subject did not experience a toxicity that met treatment discontinuation criteria
during the initial treatment with ASP1951 or ASP1951 in combination with pembrolizumab
or pembrolizumab alone.
- Subject weighs < 45 kg.
- Subject has received investigational therapy (other than an investigational EGFR TKI
in a subject with EGFR activating mutations or ALK inhibitor in a subject with an ALK
mutation) within 21 days or 5-half-lives, whichever is shorter, prior to start of
- Subject requires or has received systemic steroid therapy or any other
immunosuppressive therapy within 14 days prior to study drug administration. Subjects
using a physiologic replacement dose of hydrocortisone or its equivalent (defined as
up to 30 mg per day of hydrocortisone, 2 mg per day of dexamethasone, or up to 10 mg
per day of prednisone) are allowed.
- Subject has symptomatic CNS metastases or subject has evidence of unstable CNS
metastases even if asymptomatic (e.g., progression on scans). Subjects with previously
treated CNS metastases are eligible, if they are clinically stable and have no
evidence of CNS progression by imaging for at least 4 weeks prior to start of study
treatment and are not requiring immunosuppressive doses of systemic steroids (> 30 mg
per day of hydrocortisone, > 2 mg per day of dexamethasone, or > 10 mg per day of
prednisone or equivalent) for longer than 2 weeks.
- Subject has leptomeningeal disease as a manifestation of the current malignancy.
- Subject has an active autoimmune disease that has required systemic treatment in the
past 2 years. Subjects with type 1 diabetes mellitus, endocrinopathies stably
maintained on appropriate replacement therapy, and skin disorders (e.g., vitiligo,
psoriasis or alopecia) not requiring systemic treatment are allowed.
- Subject was discontinued from prior immunomodulatory therapy due to a grade ≥ 3
toxicity that was mechanistically related (e.g., immune related) to the agent.
- Subject has known history of serious hypersensitivity reaction (≥ grade 3) to a known
ingredient of ASP1951 or pembrolizumab or severe hypersensitivity reaction to
treatment with another monoclonal antibody.
- Subject with positive Hepatitis B virus (HBV) antibodies and surface antigen
(indicating acute HBV or chronic HBV) or Hepatitis C ([HCV]; ribonucleic acid [RNA]
detected by qualitative assay). Hepatitis C RNA testing is not required in subjects
with negative Hepatitis C antibody testing. HBV antibodies are not required in
subjects with negative HBV surface antigen.
- Subject has received a live vaccine against infectious diseases within 4 weeks prior
to initiation of study treatment.
- Subject has a history of drug-induced pneumonitis (interstitial lung disease), a
history of (non-infectious) pneumonitis that required steroids, radiation pneumonitis
or currently has pneumonitis.
- Subject has an infection requiring systemic therapy within 2 weeks prior to study drug
- Subject has received a prior allogeneic bone marrow or solid organ transplant.
- Subject is expected to require another form of antineoplastic therapy while on study
- Subject has had a myocardial infarction or unstable angina within 6 months prior to
the start of study treatment or currently has an uncontrolled illness including, but
not limited to symptomatic congestive heart failure, clinically significant cardiac
disease, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social
situations that would limit compliance with study requirements.
- Subject has received prior treatment with an anti-glucocorticoid-induced tumor
necrosis factor receptor (GITR) antibody.
- Subject has had a major surgical procedure and has not completely recovered within 28
days prior to the start of study treatment.
- Subject has any condition which makes the subject unsuitable for study participation.
- Subject has a known history of human immunodeficiency virus (HIV) infection. No HIV
testing is required unless mandated by local health authority.
- Subject has known history of coronavirus disease 2019 (COVID-19) positive polymerase
chain reaction (PCR) test within 4 weeks prior to start of study treatment.
Additional Exclusion Criterion for Subjects in Expansion Cohorts:
- Subject has a prior malignancy, other than the current malignancy for which the
subject is seeking treatment, active (i.e., requiring treatment of intervention)
within the previous 2 years except for locally curable malignancies that have been
apparently cured, such as basal or squamous cell skin cancer, superficial bladder
cancer or carcinoma in situ of the cervix or breast.
Additional Exclusion Criteria for Re-treatment:
- Subjects who have completed 45 weeks in monotherapy or 57 weeks in combination therapy
follow-up with disease control are not eligible for re-treatment.
- Subject currently has an ongoing AE related to ASP1951 or ASP1951 in combination with
pembrolizumab that meets the criteria for treatment interruption or discontinuation.