This study is evaluating the combination of Y-90 radioembolization followed by SBRT with the
immunotherapy drugs, durvalumab and tremelimumab, to improve disease control of liver
metastases for patients with microsatellite stable colorectal cancer.
1. Histologic or cytologic confirmation of metastatic microsatellite stable colorectal
2. Liver metastases not amenable to resection for which palliative Y-90 and SBRT is
considered appropriate standard therapy
3. Patients should have received at least one prior standard therapy for metastatic
disease. Prior therapies should include regimens containing oxaliplatin and irinotecan
in combination with a fluoropyrimidine if appropriate (e.g., FOLFOX and FOLFIRI or
their variants) unless contraindicated, not tolerated, or declined.
4. Male or female, age 18 or older
5. ECOG performance status of 0 or 1
6. Body weight >30 kg
7. Life expectancy of greater than 6 months
8. Evidence of post-menopausal status or negative urinary or serum pregnancy test for
female pre-menopausal patients. Women will be considered post-menopausal if they have
been amenorrheic for 12 months without an alternative medical cause. The following
age-specific requirements apply:
- Women <50 years of age would be considered post-menopausal if they have been
amenorrheic for 12 months or more following cessation of exogenous hormonal
treatments and if they have luteinizing hormone and follicle-stimulating hormone
levels in the post-menopausal range for the institution or underwent surgical
sterilization (bilateral oophorectomy or hysterectomy).
- Women ≥50 years of age would be considered post-menopausal if they have been
amenorrheic for 12 months or more following cessation of all exogenous hormonal
treatments, had radiation-induced menopause with last menses >1 year ago, had
chemotherapy-induced menopause with last menses >1 year ago, or underwent
surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or
9. Patients must have acceptable organ and marrow function as defined below:
- Hemoglobin ≥9.0 g/dL
- Absolute neutrophil count (ANC ≥1.0 x (> 1000 per mm3))
- Serum bilirubin ≤1.5 x institutional upper limit of normal (ULN).
- Total bilirubin : < 2x upper limit of normal
- AST (SGOT)/ALT (SGPT): <2.5x institutional upper limit of normal
- Creatinine: <1.5x upper limit of normal OR Creatinine clearance >40mL/min for
patients with creatinine levels above institutional normal
10. Ability to understand and willingness to sign a written informed consent document
11. Residual or on-going ≥ Grade 3 treatment-related toxicity from previous chemotherapy
should be resolved.
1. Participation in another clinical study with an investigational drug during the last 4
2. Concurrent enrollment in another clinical study, unless it is an observational
(non-interventional) clinical study or during the follow-up period of an
3. Any unresolved toxicity NCI CTCAE Grade ≥2 from previous anticancer therapy with the
exception of alopecia, vitiligo, and the laboratory values defined in the inclusion
- Patients with Grade >2 neuropathy will be evaluated on a case-by-case basis after
consultation with the Study Physician.
- Patients with irreversible toxicity not reasonably expected to be exacerbated by
treatment with durvalumab or tremelimumab may be included only after consultation
with the Study Physician.
4. Any concurrent chemotherapy, IP, biologic, or hormonal therapy for cancer treatment.
Concurrent use of hormonal therapy for non-cancer-related conditions (e.g., hormone
replacement therapy) is acceptable.
5. Major surgical procedure (as defined by the Investigator) within 28 days prior to the
first dose of IP. Note: Local surgery of isolated lesions for palliative intent is
6. History of allogenic organ transplantation.
7. Active or prior documented autoimmune or inflammatory disorders (including
inflammatory bowel disease [e.g., colitis or Crohn's disease], diverticulitis [with
the exception of diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome,
or Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid
arthritis, hypophysitis, uveitis, etc]). The following are exceptions to this
- Patients with vitiligo or alopecia
- Patients with hypothyroidism (e.g., following Hashimoto syndrome) stable on
- Any chronic skin condition that does not require systemic therapy
- Patients without active disease in the last 5 years may be included but only
after consultation with the study physician
- Patients with celiac disease controlled by diet alone
8. Prior therapy with an anti-PD-1 or anti-PD-L1, including durvalumab antibody within 6
months prior to enrollment and anti-CTLA4 (including tremelimumab)
9. Prior abdominal radiotherapy
10. Child-Pugh class B or higher
11. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, uncontrolled hypertension, insterstitial lung disease, serious chronic
gastrointestinal conditions associated with diarrhea, or psychiatric illness/social
situations that would limit compliance with study requirements, substantially increase
risk of incurring AEs or compromise the ability of the patient to give written
12. History of another primary malignancy except for:
- Malignancy treated with curative intent and with no known active disease ≥2 years
before the first dose of IP and of low potential risk for recurrence
- Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
- Adequately treated carcinoma in situ without evidence of disease
13. History of leptomeningeal carcinomatosis
14. History of active primary immunodeficiency
15. Active infection including tuberculosis (clinical evaluation that includes clinical
history, physical examination and radiographic findings, and TB testing in line with
local practice), hepatitis B (known positive HBV surface antigen (HBsAg) result),
hepatitis C, or human immunodeficiency virus (positive HIV 1/2 antibodies). Patients
with a past or resolved HBV infection (defined as the presence of hepatitis B core
antibody [anti-HBc] and absence of HBsAg) are eligible. Patients positive for
hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative
for HCV RNA.
16. Current or prior use of immunosuppressive medication within 14 days before the first
dose of durvalumab or tremelimumab. The following are exceptions to this criterion:
- Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra
- Systemic corticosteroids at physiologic doses not to exceed <<10 mg/day>> of
prednisone or its equivalent
- Steroids as premedication for hypersensitivity reactions (e.g., CT scan
17. Receipt of live attenuated vaccine within 30 days prior to the first dose of IP. Note:
Patients, if enrolled, should not receive live vaccine whilst receiving IP and up to
30 days after the last dose of IP.
18. Contraindication to IV contrast
19. Pregnant and breastfeeding women are excluded. Women of child-bearing potential who
are unwilling or unable to use an acceptable method of birth control to avoid
pregnancy from screening to 90 days after the last dose of durvalumab monotherapy or
180 days after the last dose of durvalumab + tremelimumab combination therapy are
excluded. This applies to any woman who has experienced menarche and who has not
undergone successful surgical sterilization or is not postmenopausal (defined as
amenorrhea for at least 12 consecutive months, or women on hormone replacement therapy
with serum FSH levels greater than 35 mIU/mL). A negative urine or serum pregnancy
test must be obtained within 14 days prior to the start of study therapy in all women
of child-bearing potential. Male subjects must also agree to use effective
contraception for the same time period as above.
20. Known allergy or hypersensitivity to any of the study drugs or any of the study drug
21. Use of any prohibited concomitant medications, including:
- Traditional herbal medicines, as their use may result in unanticipated drug-drug
interactions that may cause or confound assessment of toxicity.
- Any live, attenuated vaccine (e.g., FluMist) within 4 weeks prior to Cycle 1 Day
1 or at any time during the study and for at least 5 months after the last dose
- Use of steroids to premedicate patients for whom MRI scans with contrast are
contraindicated (i.e., patients with contrast allergy or impaired renal
- Immunomodulatory agents, including but not limited to interferons or
interleukin-2, during the entire study; these agents could potentially increase
the risk for autoimmune conditions when administered with durvalumab.
- Immunosuppressive medications, including but not limited to cyclophosphamide,
azathioprine, methotrexate, and thalidomide; these agents could potentially alter
the activity and the safety of durvalumab
- Systemic corticosteroids and tumor necrosis factor-α (TNF-α) inhibitors may
attenuate potential beneficial immunologic effects of treatment with durvalumab.
Therefore, in situations where systemic corticosteroids or TNF-α inhibitors would
be routinely administered, alternatives, including antihistamines, should be
considered first by the treating physician. If the alternatives are not feasible,
systemic corticosteroids and TNF-α inhibitors may be administered at the
discretion of the treating physician (see Section 4.4.2)
- Initiation or increased dose of granulocyte colony-stimulating factors (e.g.,
granulocyte colony stimulating factor, granulocyte/macrophage colony-stimulating
factor, and/or pegfilgrastim) is prohibited.
22. Shunt Fraction greater than 20% (Requires more than 30gy dose to the lungs in order
receive therapeutic dose of Y-90).