Inclusion Criteria:

          -  Pathologically (histologically) proven adenocarcinoma confirmed by prostatectomy
             performed within 10 years prior to registration and any type of radical prostatectomy
             is permitted, including retropubic, perineal, laparoscopic or robotically assisted.

          -  PSA level (≥ 0.2 ng/mL) within 90 days prior to registration. GnRH analog may be
             started no more than 42 days prior study entry, but patients must have a PSA ≥ 0.2
             ng/mL prior to starting ADT.

          -  Hemoglobin ≥ 9.0 g/dL, independent of transfusion and/or growth factors within 90 days
             prior to registration.

          -  Platelet count ≥ 75,000 x 10^9/µL independent of transfusion and/or growth factors
             within 90 days prior to registration.

          -  At least 1 of the following aggressive features:

               -  Gleason score of 8-10 (note any Gleason score is eligible)

               -  Seminal vesicle invasion (SVI) (note any pT stage [AJCC v8.0] is eligible but a
                  pT stage

                  ≥ pT3b is considered aggressive)

               -  Locoregional node involvement at radical prostatectomy (pN1)

               -  Persistently elevated PSA post-RP nadir (PEPP) defined as PSA > 0.1 ng/mL after
                  radical prostatectomy

          -  Serum albumin ≥ 3.0 g/dL within 90 days prior to registration

          -  GFR ≥35 mL/min estimated by Cockcroft-Gault or measured directly by 24 hour urine
             creatinine within 90 days prior to registration.

          -  Serum total bilirubin ≤1.5 × ULN (Note: In subjects with Gilbert's syndrome, if total
             bilirubin is >1.5 × ULN, measure direct and indirect bilirubin and if direct bilirubin
             is ≤1.5 × ULN, subject is eligible) within 90 days prior to registration.

          -  Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) <2.5 × ULN within
             90 days prior to registration.

          -  Testosterone >50 ng/dL within 90 days prior to registration. Prior androgen
             deprivation (GnRH analog and/or non-steroidal antiandrogen) therapy is allowed
             provided that serum testosterone concentration must be ≥ 50 ng/dL prior to
             registration or starting ADT, whichever occurs first; 5-alpha reductase inhibitors
             will not impact eligibility, but must be discontinued prior to starting protocol
             treatment.

          -  History and physical with ECOG Performance Status 0-1 or within 90 days prior to
             registration.

        Exclusion Criteria:

          -  Definitive clinical or radiologic evidence of metastatic disease with the exception of
             locoregional lymph nodes.

          -  Prior invasive malignancy (except non-melanomatous skin cancer carcinoma in situ of
             the male breast, penis, oral cavity, or stage Ta of the bladder, or stage I completely
             resected melanoma) unless disease free for a minimum of 2 years).

          -  Prior systemic chemotherapy for the study cancer. Note: prior chemotherapy for a
             different cancer is allowable.

          -  Prior radiotherapy to the region of the study cancer that would result in overlap of
             radiation therapy fields.

          -  History of any of the following:

               -  Documented inflammatory bowel disease

               -  Transmural myocardial infarction within the last 4 months prior to registration.

               -  New York Heart Association Functional Classification III/IV within 4 months prior
                  to registration.

               -  Unstable angina and/or congestive heart failure requiring hospitalization within
                  the last 4 months prior to registration

               -  History of loss of consciousness or transient ischemic attack within 12 months
                  prior to randomization

               -  History of seizure disorder or condition that may predispose to seizure (e.g.
                  prior cortical stroke or significant brain trauma)

               -  History of uncontrolled hypertension defined as a sustained systolic blood
                  pressure in excess of 150 mmHg or a sustained diastolic blood pressure in excess
                  of 90 mmHg despite optimized antihypertensive therapy.

               -  History of repeated falls and fractures over the past 12 months that in the
                  opinion of the treating investigator would put the patient at risk for poor bone
                  outcomes from androgen receptor targeted therapy

          -  Known gastrointestinal disorder affecting absorption of oral medications.

          -  Active uncontrolled infection defined as an identified infectious condition that
             requires active therapy that has not yet been completed.

          -  HIV positive patients with CD4 count < 200 cells/microliter within 30 days prior to
             registration OR HIV patients under treatment with highly active antiretroviral therapy
             (HAART) within 30 days prior to registration regardless of CD4 count. Note: HIV
             testing is not required for eligibility for this protocol as it is self-reported. This
             exclusion criterion is necessary because the treatments involved in this protocol may
             be immunosuppressive and/or interact with HAART.