Inclusion Criteria:

          1. Part A: Patients with histologically or cytologically confirmed progressive or
             metastatic NSCLC, pancreatic, or colorectal cancer that have failed standard treatment
             and for which no other effective treatment is available or appropriate for the patient
             up to dose level 4. In dose level 5, patients with histologically or cytologically
             confirmed progressive or metastatic NSCLC with documented KRAS-mutant genotype, who
             have failed standard treatment and have no other effective treatment available or
             appropriate for the patient.

             Part B: Patients with histologically or cytologically confirmed progressive or
             metastatic NSCLC with documented KRAS-mutant genotype, who have failed standard
             treatment and have no other effective treatment available or appropriate for the
             patient.

          2. Eastern Cooperative Oncology Group performance status of 0-2.

          3. Men and women ≥ 18 years of age.

          4. Patients must have recovered from all acute adverse effects (excluding alopecia) of
             prior therapies to baseline or ≤ Grade 1 prior to study entry.

          5. Adequate bone marrow function, defined as an absolute neutrophil count (ANC) ≥ 1.5 x
             109/L and a platelet count ≥ 100 x 109/L.

          6. Adequate renal function, defined as serum creatinine ≤ 1.5 x upper limit of normal
             (ULN) for the institution or calculated creatinine clearance [Cockcroft-Gault method]
             must be ≥ 60 mL/min/1.73 m². If serum creatinine is >1.5 x ULN, then creatinine
             clearance can be calculated from a 24-hour urine collection.

          7. Adequate hepatic function, defined as total bilirubin ≤ 1.5 mg/dL and alanine
             transaminase (ALT) and aspartate transaminase (AST) ≤ 2.5 x ULN, or ≤ 5 x ULN if known
             liver metastases.

          8. Female patients of childbearing potential must have a negative serum or urine
             pregnancy test result at time of pre-treatment screening.

          9. Patients with reproductive potential must agree to use at least one form of highly
             effective contraception prior to study entry and for up to 30 days beyond the last
             administration of study drug.

         10. Patients must be capable of providing informed consent and must be willing to provide
             written informed consent prior to the start of any study-specific procedures.

         11. All patients must have measurable tumor per RECIST 1.1.

         12. Agree to adhere to all study protocol requirements.

        Exclusion Criteria:

          1. Prior chemotherapy, radiation therapy, or investigational therapy within 4 weeks
             (exception: 6 weeks for nitrosoureas or mitomycin C); or prior non-cytotoxic therapy
             within 5 drug half-lives (or 4 weeks, whichever is shorter); or monoclonal antibodies
             within 4 weeks prior to the first dose of study treatment.

          2. Concurrent use of any other investigational agent.

          3. Known or clinically suspected central nervous system or leptomeningeal metastases,
             unless irradiated or treated a minimum of 4 weeks prior to first study treatment and
             stable without requirement of corticosteroids for > 1 week.

          4. Pregnant or breast feeding. A negative pregnancy test must be documented at baseline
             for women of childbearing potential. Patients may not breast-feed infants while on
             this study.

          5. Significant cardiovascular disease or condition, including:

               1. Congestive heart failure currently requiring therapy

               2. Need for antiarrhythmic medical therapy for ventricular arrhythmia

               3. Severe conduction disturbance

               4. Angina pectoris requiring therapy

               5. QTc interval > 450 msec (males) or > 470 msec (females) Fridericia's correction.

                  Note: QTc values up to 500 ms will be acceptable where patient's medical history
                  e.g. bundle branch block, is known to cause mild QTc prolongation and the
                  condition is well controlled.

               6. History of congenital long QT syndrome or congenital short QT syndrome

               7. Uncontrolled hypertension (per the Investigator's discretion)

               8. Class III or IV cardiovascular disease according to the New York Heart
                  Association's Functional Criteria

               9. Myocardial infarction within 6 months prior to first study drug administration

          6. Known history of human immunodeficiency virus or active infection with hepatitis B
             virus or hepatitis C virus.

          7. Known uncontrolled intercurrent illnesses, including uncontrolled viral influenza and
             COVID 19, systemic bacterial infections, and fungal infections.

          8. Psychiatric disorder or altered mental status that would preclude understanding of the
             informed consent process and/or completion of the necessary studies.

          9. Known allergic reactions to H1/H2 antagonists.