Inclusion Criteria:

          -  Bone marrow blasts >= 5% that develops after CR/CRi in patient with prior history of
             AML, no restriction on prior number of relapses or regimens

          -  AML characterized by the IDH2 gene mutation, without requirement for a particular
             allelic frequency

          -  Patients previously treated with IDH2 inhibitor can be enrolled

          -  At least a 3-month duration of CR/CRi prior to relapse

          -  Relapses after allogeneic HSCT are included with a minimum of 3 from the date of
             allogeneic HSCT

          -  Up to 1 cycle of hypomethylating agent monotherapy at time of relapse is allowed, must
             be discontinued at least 14 days prior to start of salvage induction

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0-2

          -  Serum total bilirubin < 2.0 mg/dL, unless considered due to Gilbert?s disease or
             leukemic involvement

          -  Aspartate aminotransferase (AST), alanine aminotransferase (ALT) < 3 times the upper
             limit of normal, unless considered due to leukemic involvement

          -  Alkaline phosphatase < 3 times the upper limit of normal, unless considered due to
             leukemic involvement

          -  Serum creatinine =< 2.0 mg/dL, or creatinine clearance > 40 mL/min based on
             Cockcroft-Gault glomerular filtration rate (GFR)

          -  Females of reproductive potential as well as fertile men and their partners who are
             female of reproductive potential must agree to abstain from sexual intercourse or to
             use two highly effective forms of contraception from the time of giving informed
             consent, during the study, and for four months (females and males) following the last
             dose of IDH inhibitor. A highly effective form of contraception is defined as hormonal
             oral contraceptives, injectables, patches, intrauterine devices, double-barrier method
             (eg, synthetic condoms, diaphragm or cervical cap with spermicidal foam, cream, or
             gel) or male partner sterilization

        Exclusion Criteria:

          -  Concurrent FLT3 mutation that the treating physician deems necessary to treat with
             FLT3-targeted therapy; whereas, patients with FLT3-mutated AML not treated with
             FLT3-targeted therapy can be enrolled

          -  Inability to swallow medications or history of gastrointestinal (GI) malabsorptive
             disease

          -  Active malignancy that would limit survival by less than two years

          -  New York Heart Association class III or VI

          -  Left ventricular ejection fraction < 40%

          -  History of coronary stent placement that require mandatory continuation of
             dual-antiplatelet therapy

          -  Baseline QT corrected interval based on Fridericia?s formula (QTcF) interval > 450 ms

          -  History of Wilson?s disease or other copper handling disorders

          -  Hypersensitivity to cytarabine, daunorubicin, or liposomal products

          -  Active hepatitis B with surface antibody positivity (participants with hepatitis B
             core antibody positivity can be enrolled if given concurrent entecavir)

          -  Hepatitis C immnuoglobulin (Ig)G antibody positivity, unless received curative
             hepatitis C therapy and now with hepatitis C ribonucleic acid (RNA) undetectable

          -  Active invasive fungal infection

          -  Active bacterial or viral infection manifesting as fevers or hemodynamic instability
             within the past 72 hours

          -  Lifetime cumulative daunorubicin-equivalent anthracycline dose > 368 mg/m^2

          -  Pregnant or breast feeding