Inclusion Criteria:

          -  Be willing and able to provide informed consent for the trial

          -  Histological confirmation of RCC with a clear-cell component

          -  Advanced (not amenable to curative surgery or radiation therapy) or metastatic
             (American Joint Committee on Cancer [AJCC] stage IV) RCC

          -  Intermediate or poor risk disease by International Metastatic RCC Database Consortium
             (IMDC) classification

          -  No prior systemic therapy for RCC with the following exception:

               -  One prior adjuvant or neoadjuvant therapy for completely resectable RCC if such
                  therapy did not include an agent that targets PD-1 or PD-L1 and if recurrence
                  occurred at least 6 months after the last dose of adjuvant or neoadjuvant therapy

          -  Eastern Cooperative Oncology Group (ECOG) performance status < 2

          -  Measurable disease as per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1

          -  Any ethnicity or race

          -  Calculated creatinine clearance >= 30 milliliters per minute (mL/min) per the
             Cockcroft and Gault formula or serum creatinine < 1.5 x upper limit of normal (ULN)

          -  Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x ULN (< 5 x
             ULN if liver metastases are present)

          -  Total bilirubin < 1.5 x ULN (except subjects with Gilbert syndrome, who can have total
             bilirubin up to 3.0 mg/dL)

          -  White blood cells (WBC) > 2,000/mm^3

          -  Neutrophils > 1,500/mm^3

          -  Platelets > 100,000/mm^3

        Exclusion Criteria:

          -  Presence of untreated brain metastases. Patients with treated brain metastases must be
             stable for 4 weeks after completion of treatment and have documented stability on
             pre-study imaging. Patients must have no clinical symptoms from brain metastases and
             have no requirement for systemic corticosteroids amounting to > 10 mg/day of
             prednisone or its equivalent for at least 2 weeks prior to first dose of study drug.
             Patients with known leptomeningeal metastases are excluded, even if treated

               -  Not recovered to =< grade 1 toxicities related to any prior therapy before
                  administration of study drug

          -  Favorable risk disease by IMDC classification

          -  Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4
             antibody, or any other antibody or drug specifically targeting T-cell co-stimulation
             or checkpoint pathways

          -  Any active or recent history of a known or suspected autoimmune disease or recent
             history of a syndrome that required systemic corticosteroids (> 10 mg daily prednisone
             equivalent) or immunosuppressive medications except for syndromes which would not be
             expected to recur in the absence of an external trigger. Subjects with vitiligo or
             type I diabetes mellitus or residual hypothyroidism due to autoimmune thyroiditis only
             requiring hormone replacement are permitted to enroll

          -  Active interstitial lung disease (ILD)/pneumonitis or history of ILD/pneumonitis
             requiring treatment with systemic steroids

          -  Baseline pulse oximetry less than 92% "on room air"

          -  Current use, or intent to use, probiotics, yogurt or bacterial fortified foods during
             the period of treatment

          -  Any condition requiring systemic treatment with corticosteroids (> 10 mg daily
             prednisone equivalents) or other immunosuppressive medications within 14 days prior to
             first dose of study drug. Inhaled steroids and adrenal replacement steroid doses > 10
             mg daily prednisone equivalents are permitted in the absence of active autoimmune
             disease

          -  Uncontrolled adrenal insufficiency

          -  Known medical condition (e.g., a condition associated with diarrhea or acute
             diverticulitis) that, in the investigator's opinion, would increase the risk
             associated with study participation or study drug administration or interfere with the
             interpretation of safety results

          -  Not recovered to =< grade 1 toxicities related to any prior therapy before
             administration of study drug

          -  Women who are pregnant or breastfeeding

          -  History of myocarditis or congestive heart failure (as defined by New York Heart
             Association functional classification III or IV), as well as unstable angina, serious
             uncontrolled cardiac arrhythmia, uncontrolled infection, or myocardial infarction 6
             months prior to study entry

          -  White blood cells (WBC) < 2,000/mm^3

          -  Neutrophils < 1,500/mm^3

          -  Platelets < 100,000/mm^3

          -  Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x upper limit
             of normal (ULN) (> 5 x ULN if liver metastases are present)

          -  Total bilirubin > 1.5 x ULN (except subjects with Gilbert syndrome, who can have total
             bilirubin 3.0 mg/dL)

          -  Calculated creatinine clearance < 30 millimeters per minute (mL/min) per the Cockcroft
             and Gault formula or serum creatinine > 1.5 x upper limit of normal (ULN)