Inclusion Criteria:

        1. Age ≥ 18 years old at time of informed consent 2. Histologically confirmed MIBC (T2-T4)
        pure or mixed histology urothelial carcinoma [urothelial carcinoma should be the dominant
        (>50%) histology].

        3. Refusing cisplatin-based chemotherapy or ineligible for cisplatin-based chemotherapy due
        to at least one of the following:

          1. Creatinine clearance < 60 mL/min (by Cockgroft-Gault calculation and/or measured
             creatinine clearance)

          2. Hearing loss ≥ grade 2 by CTCAE criteria and/or;

          3. Neuropathy ≥ grade 2 by CTCAE criteria and/or

          4. Heart failure NYHA ≥ III 4. Medically fit for TURBT and radical cystectomy 5. Adequate
             organ and marrow function as defined below:

        a. Absolute neutrophil count ≥ 1.5 K/mm3 b. White blood cell count (WBC) > 3.0 K/mm3 c.
        Platelets ≥ 100 K/mm3 d. Hemoglobin ≥ 9 g/dL e. Serum total bilirubin ≤ 1.5 x ULN (Patients
        with Gilbert's syndrome with a total bilirubin ≤2.0 times ULN and direct bilirubin within
        normal limits are permitted) f. ALT and AST ≤ 2.5 x ULN g. Serum creatinine clearance
        (CrCl) ≥ 30 ml/min using the MDRD or serum creatinine ≤ 2 times ULN.using the
        Cockcroft-Gault or measurement with 24 hour urine collection 6. Ability to swallow oral
        medications 7. Patients who received radiotherapy must have completed and fully recovered
        from the acute effects of radiotherapy. A washout period of at least 14 days is required
        between end of radiotherapy and randomization Exclusion Criteria

          1. Patients with locally advanced unresectable or metastatic urothelial carcinoma as
             assessed on baseline radiographic imaging obtained within from the date of signed
             consent, 28 days prior to study enrollment. Low volume (<1.5 cm) suspicious lymph node
             metastases in the pelvis are allowed if they are in the LN dissection template field.
             The required radiographic imaging includes:

               1. Abdomen/pelvis - CT/MRI

               2. Chest - chest x-ray or CT scan

               3. Bone scan or FDG-PET/CT in the presence of bone pain or unexplained elevated
                  alkaline phosphatase

          2. Patients with another active second malignancy other than non-melanoma skin cancers
             and localized prostate cancer. Patients that have completed all necessary therapy and
             are considered to be <30% risk of relapse are not considered to have an active second
             malignancy and are eligible for enrollment.

          3. Patients who have received anti-cancer therapy including chemotherapy, radiotherapy,
             immunotherapy, and monoclonal antibodies ≤ 4 weeks prior to starting study drug, or
             who have not recovered from the side effects of such therapy

          4. Patients who have serious and/or uncontrolled preexisting medical condition(s) that,
             in the judgment of the investigator, would preclude participation in this study (for
             example, interstitial lung disease, severe dyspnea at rest or requiring oxygen
             therapy, severe renal impairment [e.g. estimated creatinine clearance <30ml/min],
             history of major surgical resection involving the stomach or small bowel, or
             preexisting Crohn's disease or ulcerative colitis or a preexisting chronic condition
             resulting in baseline Grade 2 or higher diarrhea).

          5. Have an active active bacterial infection (especially if requiring IV antibiotics),
             systemic fungal and/or known viral infection (for example, human immunodeficiency
             virus antibodies, hepatitis B surface antigen, or hepatitis C antibodies).

          6. Subjects who received a strong CYP3A inhibitor within 7 days prior to the first dose
             of study drug, or patients who require continuous treatment with a strong CYP3A
             inhibitor

          7. The patient has a personal history of any of the following conditions: syncope of
             cardiovascular etiology, ventricular arrhythmia of pathological origin (including, but
             not limited to, ventricular tachycardia and ventricular fibrillation), or sudden
             cardiac arrest.

          8. Pregnant or breast-feeding women

          9. Women who do not agree to use a medically approved contraceptive method during the
             treatment period and for 3 months following the last dose of Abemaciclib

         10. Men who do not agree to use a reliable method of birth control and to not donate sperm
             during the study and for at least 3 months following the last dose of Abemaciclib

         11. Subjects unwilling or unable to comply with the protocol