Inclusion Criteria:

          1. Refractory or relapsed AML which will include:

               1. Refractory disease will be defined as at least 1 prior treatment with no
                  remission.

               2. Relapsed disease will be defined as 5% or more blasts in bone marrow seen after
                  remission.

               3. Patients with AML arising from myelodysplastic syndromes (including CMML) or
                  myeloproliferative neoplasms (secondary AML, ts-AML) are also eligible.

          2. Circulating blast count ≤ 200/μL within 10 days prior to first cycle of treatment.
             Hydroxyurea should be used to keep the peripheral blast count ≤ 200/μL until the first
             day of protocol treatment, to the extent that this is possible

          3. ECOG ≤ 2

          4. Estimated creatinine clearance ≥ 50 mL/min

          5. AST and ALT ≤ 3.0 x ULN

          6. Bilirubin ≤ 3.0 x ULN

        Exclusion Criteria:

          1. Active CNS Leukemia.

          2. Known HIV infection or known hepatitis B or hepatitis C infection (with a detectable
             viral load).

          3. Participant has received strong and/or moderate CYP3A inducers within 7 days prior to
             the initiation of study treatment.

          4. Have received prior radiation to maximally tolerated levels to any critical normal
             organ.

          5. Clinically significant cardiac disease.

          6. Active, uncontrolled serious infection.

          7. Have other non-myeloid malignancy within 2 years of entry (with exceptions).

          8. Psychiatric disorder that would preclude study participation

          9. Previous solid organ transplant (prior treatment with SCT is allowed but not if
             patient has GVHD or is still receiving immunosuppression/GVHD therapy).