The primary purpose of this study is to determine if 8 weeks of topical remetinostat applied
three times daily will suppress Squamous Cell Carcinoma.
The primary purpose of this study is:
- to determine if 8 weeks of topical remetinostat gel applied 3 times daily (TID) under
occlusion will suppress SCC growth
- to determine the overall response rate (ORR) of SCCs after 8 weeks of treatment with
topical remetinostat gel 1%, as measured by at least 30% decrease in greatest area (in
- Subjects with at least 1 biopsy-proven cutaneous SCC will be recruited for this
- Subjects will apply remetinostat gel 1% to at least 1 SCC.
- Non-invasive cutaneous SCC lesions, including Bowen's disease, are also eligible
for this study
- There is 1 treatment option: Topical remetinostat gel 1% applied 3 times daily.
- The study is a single arm, open label design
- For purposes of ClinicalTrials.gov, there is no secondary outcome.
1. Must have at least one biopsy-proven cutaneous SCC or SCC in situ (SCC-IS) lesion
greater than or equal to 5 mm. Non-invasive SCC lesion(s), including Bowen's disease
(SCC-IS), are eligible, but must be amenable to surgical resection.
2. 18 years of age or older.
3. Must be willing to apply the topical remetinostat 3 times daily for 8 weeks and cover
with an occlusive bandage.
4. Negative serum pregnancy test within 14 days prior to the first dose of study therapy
for women of child-bearing potential, defined as a sexually mature woman who has not
undergone a hysterectomy or who has not been naturally postmenopausal for at least 24
consecutive months (i.e., who has had menses any time in the preceding 24 consecutive
5. Sexually active women of child bearing potential (WCBP) and male patients with a
female partner of child-bearing potential must agree to use acceptable methods of
contraception to avoid pregnancy (for example, oral, injectable, or implantable
hormonal contraceptive; tubal ligation; intra-uterine device; barrier contraceptive
with spermicide; or vasectomized partner) before the first dose of study therapy and
for 3 months after the last dose of study therapy
6. Has signed and dated the current, approved informed consent document.
1. Any large (> 20 mm) SCC lesion. Patients with large SCC lesion(s) will be referred for
evaluation for surgical resection.
2. Inoperable locally-advanced and/or non-cutaneous metastatic SCC.
3. SCC lesion(s) in cosmetically-sensitive areas (e.g. tip of nose, eyelid) are not
eligible for enrollment. (If a patient has SCC lesion(s) in other areas, those
tumor(s) may be considered for enrollment.)
4. Taking any medication known to affect SCC growth
5. Within the past 6 months, has used topical or systemic therapies that might interfere
with the evaluation of the study medication during the study. Specifically, these
include the topical use at the site of the study tumors:
- Retinoids either systemically or topically at the tumor site (e.g., etretinate,
isotretinoin, tazarotene, tretinoin, adapalene)
- Alpha-hydroxy acids (e.g., glycolic acid, lactic acid) to the tumor site
- 5-fluorouracil or imiquimod
6. Has received treatment with systemic chemotherapy within 60 days prior to starting
7. Currently receiving systemic medications that could affect SCC tumors (e.g., oral
retinoids) or might interact with remetinostat
8. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, recurrent seizure history or psychiatric illness/social situations that
would limit compliance with study requirements.
9. Moderate to significant immunosuppression (e.g., active cancer, significant autoimmune
disease) and/or receiving immunosuppressive drugs that result in moderate to
significant immunosuppression (e.g. low dose oral glucocorticoids do not necessarily
exclude a patient)
10. Known or previous hypersensitivity to HDACi
11. History of congestive heart failure, cardiac arrhythmias, or other findings of
12. Pregnancy or breast-feeding.