Key Inclusion Criteria:

          -  Ability to understand and the willingness to sign a written informed consent document

          -  Participants, both men and women, must agree to use an adequate method of
             contraception prior to study entry, for the duration of study participation, and for 4
             months after completion of study

          -  Women of childbearing potential must have a negative serum or urine pregnancy test
             within 14 days prior to start of study drug administration

          -  Patients must have a histologically or cytologically-confirmed metastatic solid tumor
             or hematological malignancy that has progressed as follows:

               -  Patients with a solid tumor must have metastatic disease and have progressed on
                  at least 1 line of established therapy that is known to provide clinical benefit,
                  or for whom no standard curative therapy exists. Participants with newly
                  diagnosed, unresectable, locally-advanced or metastatic pancreatic adenocarcinoma
                  and are beginning first-line treatment with a course of chemotherapy are eligible
                  OR

               -  Participants must have a hematological malignancy that is advanced, relapsed, or
                  refractory to at least 1 line of established therapy that is known to provide
                  clinical for the treatment of their disease. Hematological disease included in
                  this study are as follows:

                    -  Acute myelogenous leukemia (AML), or

                    -  Myelodysplastic syndrome (MDS), or

                    -  MDS/myeloproliferative neoplasms (MDS/MPN), or

                    -  Primary myelofibrosis (PMF)

                    -  Acute lymphoblastic leukemia (ALL)

                    -  Chronic myelogenous leukemia (CML)

                    -  Non-Hodgkin lymphoma (NHL) or Hodgkin's disease (HD)

                    -  Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)

                    -  Multiple myeloma (MM)

          -  Participants with a metastatic solid tumor or advanced hematological malignancy whom,
             due to medical issues cannot receive standard therapy shown to prolong survival, will
             be eligible, if other eligibility criteria are met

               -  Patients with a metastatic solid tumor or advanced hematological malignancy that
                  actively refuse chemotherapy that is considered standard treatment for their
                  cancer, despite being informed by the investigator about the treatment options,
                  are eligible for this study on a case-by-case basis (in consultation with the
                  principal investigator [PI]). Potential participants actively refusing
                  chemotherapy must have had progression or refractory disease prior to starting
                  study treatment, and their refusal must be documented

          -  Participants must have measurable disease:

               -  Patients with solid tumors must have measurable disease as defined by Response
                  Evaluation Criteria in Solid Tumors (RECIST) version (v) 1.1. At least one lesion
                  that can be accurately measured in at least one dimension (longest diameter to be
                  recorded for non-nodal lesions and short axis for nodal lesions) as >= 20 mm with
                  conventional techniques or as >= 10 mm with spiral computed tomography (CT) scan,
                  per RECIST (v1.1)

               -  Note: Participants with lesions on a bone scan that are considered distinctly
                  metastatic will also be included

               -  Patients with lymphoma must have at least one non-irradiated tumor mass > 15 mm
                  (long axis of lymph node) or > 10 mm (short axis of lymph node or extranodal
                  lesions) on spiral CT-scan

               -  Patients with CLL must have presence of radiographically measurable
                  lymphadenopathy (defined as the presence of >= 1 nodal lesion that measures >=
                  2.0 cm in the longest diameter [LD] and >= 1.0 cm in the longest perpendicular
                  diameter [LPD] as assessed by CT or magnetic resonance imaging [MRI])

               -  Patients with MM must have at least one of the following: serum monoclonal
                  component > 1 g/dL (IgG), or > 0.5 g/dL (IgA), or Bence-Jones (BJ) proteinuria >
                  200 mg/24 hour, or measurable plasmacytoma (not previously irradiated)

          -  Participants with a hematological malignancy must have their bone marrow biopsy and
             aspirate reviewed at Oregon Health & Science University (OHSU)

          -  Participants with a solid tumor must have lesions meeting the above criteria also and
             must be amenable to biopsy procedures performed per institutional standards

          -  Participants must not currently be receiving any other investigational agents

          -  Participants must have Eastern Cooperative Oncology Group (ECOG) performance status =<
             2 and a physician assessed life expectancy of >= 6 months

          -  Absolute neutrophil count (ANC) >= 1,500/mcL (at time of registration and within 4
             weeks prior to initiating on-protocol treatment)

               -  Waived for those with hematological malignancy; and may be waived on a
                  case-by-case basis for patient populations recognized to have normal baseline
                  values below this level

          -  Platelets >= 100,000/mcL (at time of registration and within 4 weeks prior to
             initiating on-protocol treatment)

               -  Waived for those with hematological malignancy

          -  Hemoglobin >= 9 g/dL or >= 5.6 mmol/L (at time of registration and within 4 weeks
             prior to initiating on-protocol treatment)

               -  Waived for those with hematological malignancy

          -  Creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine
             clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or
             creatinine clearance [CrCl]) >= 60 mL/min/1.73 m^2 for participants with creatinine
             levels > 1 x institutional ULN (at time of registration and within 4 weeks prior to
             initiating on-protocol treatment)

               -  Waived for those with hematological malignancy; and may be waived on a
                  case-by-case basis for patient populations recognized to have normal baseline
                  values below this level

          -  Total bilirubin =< 1.5 x ULN OR direct bilirubin =< ULN for participants with total
             bilirubin levels > 1.5 x ULN (at time of registration and within 4 weeks prior to
             initiating on-protocol treatment)

               -  Creatinine clearance should be calculated per institutional standard. For
                  participants with a baseline calculated creatinine clearance below normal
                  institutional laboratory values, a measured baseline creatinine clearance should
                  be determined. Individuals with higher values felt to be consistent with inborn
                  errors of metabolism will be considered on a case-by-case basis

          -  Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and
             alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 x
             ULN (at time of registration and within 4 weeks prior to initiating on-protocol
             treatment)

          -  International normalized ratio (INR) or prothrombin time (PT) =< 1.5 x ULN unless
             participant is receiving anticoagulant therapy as long as PT or partial thromboplastin
             time (PTT) is within therapeutic range of intended use of anticoagulants (at time of
             registration and within 4 weeks prior to initiating on-protocol treatment)

          -  Activated partial thromboplastin time (aPTT) or PTT =< 1.5 x ULN unless participant is
             receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of
             intended use of anticoagulants (at time of registration and within 4 weeks prior to
             initiating on-protocol treatment)

          -  Body mass index (BMI) > > 16.0 and < 35.0 kg/m^2 (at time of registration and within 4
             weeks prior to initiating on-protocol treatment)

               -  Participants with a BMI of >= 30.0 will use ideal body weight indices in
                  calculating the delivery of agents that are dosed based upon body surface area
                  (i.e., mg agent/meter squared) or weight (i.e., mg agent/kg body weight)

          -  Any prior therapy, radiotherapy (except palliative radiation therapy of 30 Gy or
             less), or major surgery must have been completed >= 4 weeks prior to start of study
             treatment. All adverse events due to prior therapy must have resolved to a grade 1 or
             better (except alopecia and lymphopenia for all disease cohorts, and hematologic
             toxicity for those with a hematological malignancy) by start of treatment. Palliative
             radiation therapy must have been completed at least 2 weeks prior to start of
             treatment. The radiotherapy must not be to a lesion that is included as measurable
             disease

          -  Additional cancer-specific inclusion criteria must also be met

        Key Exclusion Criteria:

          -  Participants with metastases to the central nervous system that are considered
             uncontrolled and/or were diagnosed within the past 4 weeks of screening for this study

          -  Participants cannot have an active malignancy of another cancer. Those with a history
             of prior malignancy will be considered on a case-by-case basis. Guiding examples for
             those who can be enrolled include: individuals who have been disease free for > 5
             years; individuals who are considered to have a high likelihood of being cured (e.g.,
             prior history of stage 1 rectal cancer and currently otherwise disease free);
             adequately treated localized non-melanomatous skin cancer

          -  Participants cannot be on other forms of anti-cancer therapy at the same time, except
             as described within this protocol. There must be at least a washout period that
             accounts for 5 half-lives (or >= 21 days, whichever is longer) of last therapy

               -  Participants with prostate cancer (PCa) will continue treatment with androgen
                  deprivation therapy, either by prior castration or treatment with luteinizing
                  hormone-releasing hormone (LHRH) antagonists or agonists, as is standard practice

               -  Participants with breast cancer (BCa) who are HER2 positive may continue to
                  receive anti-HER2 therapy per standard practice guidelines, while participants
                  who are hormone receptor positive may continue to receive hormone therapy per
                  standard practice guidelines

               -  Participants with a hematological malignancy may continue to receive hydroxyurea
                  or other hypomethylating agent for two cycles of SMMART-PRIME therapy, as
                  described in this protocol

          -  Uncontrolled intercurrent illness including, but not limited to, symptomatic
             congestive heart failure, unstable angina pectoris, serious cardiac arrhythmia,
             myocardial infarction within 6 months prior to enrollment, New York Heart Association
             (NYHA) class III or IV heart failure

          -  Chronic graft versus host disease (GVHD) or on immunosuppressive therapy for the
             control of GVHD

          -  Participants with uncontrolled infection will not be enrolled until infection is
             treated

          -  Participant is seropositive with human immunodeficiency virus (HIV) or has active
             infection with hepatitis B virus (HBV) or hepatitis C virus (HCV)

               -  HIV-infected patients on effective anti-retroviral therapy with undetectable
                  viral load within 6 months are eligible for this trial

               -  For patients with evidence of chronic HBV infection, the HBV viral load must be
                  undetectable on suppressive therapy, if indicated

               -  Individuals with a history of HCV infection must have been treated and cured. For
                  patients with HCV infection who are currently on treatment, they are eligible if
                  they have an undetectable HCV viral load

          -  Participants with medical conditions, inclusive of psychiatric, that in the opinion of
             the investigators would jeopardize the patient or the study will be excluded

          -  Participants that are pregnant or breast feeding

          -  ON-TREATMENT: Individuals that have medical and/or psychiatric conditions that in the
             opinion of investigators would jeopardize participant safety or study integrity if
             they were to receive on-study treatment will not proceed further treatment and will be
             removed from study

          -  ON-TREATMENT: If performance status is ECOG > 2

          -  ON-TREATMENT: History of allergic reaction to a recommended study agent or its
             excipients

          -  Additional cancer-specific exclusion criteria requirements