Inclusion Criteria:

          1. Patient has signed the Informed Consent Form (ICF) and is able to comply with protocol
             requirements.

          2. Patient has adequate organ function as defined by the following laboratory values:

               -  Creatinine clearance (CrCl) ≥ 60ml/min

               -  Total serum bilirubin < 1.5 x Upper Limit of Normal (ULN) or total bilirubin ≤
                  3.0 x ULN with direct bilirubin within normal range only in patients with well
                  documented Gilbert's syndrome or hemolysis or who required regular blood
                  transfusions

               -  Alanine aminotransferase (AST) and aspartate aminotransferase (ALT) < 3.0 x ULN

          3. Age ≥18 years at the time of signing the informed consent form.

          4. Documented diagnosis of MDS or MDS/myeloproliferative neoplasm (MPN) by World Health
             Organization (WHO) criteria that require treatment due to cytopenias and meet the
             International Prognostic Scoring System (IPSS) criteria for low or int-1 risk.

          5. For non-del(5q) patients, failed prior treatment with at least 2 cycles started of
             azacitidine or decitabine or lenalidomide defined as no response to treatment, loss of
             response at any time point while on treatment or within 6 months of treatment
             discontinuation, or progressive disease/intolerance to therapy.

          6. For del(5q) patients, failed prior treatment with at least 2 cycles started of
             lenalidomide defined as no response to treatment, loss of response at any time point,
             or progressive disease/intolerance to therapy.

          7. An Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2.

          8. Women of child-bearing potential and men must agree to use adequate contraception
             (hormonal or barrier method of birth control; abstinence; tubal ligation, partner's
             vasectomy) prior to Cycle 1 Day 1 (C1D1) and for the duration of study participation.
             Should a woman become pregnant or suspect she is pregnant while participating in this
             study, she should inform her treating physician immediately.

        Exclusion Criteria:

          1. Patient has a known history of HIV infection (testing not mandatory).

          2. Patient has any of the following cardiac abnormalities:

               -  symptomatic congestive heart failure

               -  myocardial infarction ≤ 6 months prior to enrollment

               -  unstable angina pectoris as designated by the treating physician

               -  serious uncontrolled cardiac arrhythmia as designated by the treating physician

               -  QTcF (Fridericia's correction formula) ≥ 450 msec

          3. Concomitant malignancies or previous malignancies with less than a 1-year disease free
             interval at the time of enrollment. Patients with adequately resected basal or
             squamous cell carcinoma of the skin, or adequately resected carcinoma in situ (i.e.
             cervix) may enroll irrespective of the time of diagnosis.

          4. Use of chemotherapeutic agents or experimental agents (agents that are not
             commercially available) for the treatment of MDS within 14 days of the first day of
             study drug treatment.

          5. No concurrent use of erythroid stimulating agents, Granulocyte-colony stimulating
             factor (G-CSF), Granulocyte-macrophage colony-stimulating factor (GM-CSF) is allowed
             during study except in cases of febrile neutropenia where G-CSF can be used for short
             term. Growth factors must be stopped two weeks prior to study.

          6. Pregnant women are excluded from this study because LB-100 has not been studied in
             pregnant subjects. Because there is an unknown but potential risk for adverse events
             in nursing infants secondary to treatment of the mother with LB-100, breastfeeding
             should be discontinued if the mother is treated with LB-100.