Inclusion Criteria:

        Participants are eligible to be included in the study only if all the following criteria
        apply.

          1. Subject has voluntarily agreed to participate by giving written informed consent in
             accordance with ICH/GCP guidelines and applicable local regulations.

          2. Subject has a histologically confirmed diagnosis of one of the following unresectable
             locally advanced or metastatic malignancies: melanoma, non-small cell lung cancer
             (squamous, adeno, or adeno-squamous), urothelial cancer, squamous cell carcinoma of
             the head and neck, squamous cell cervical cancer, gastric or gastro-esophageal
             junction adenocarcinoma, squamous cell carcinoma of the anal canal, squamous cell
             carcinoma of the skin, renal cell cancer, Hodgkin's lymphoma, and microsatellite
             instability high (MSI-H) or mismatch repair deficient (MMRD) solid tumors excluding
             CNS malignancies. MSI and MMRD testing results as per institution is acceptable.

               -  Head and neck cancers: Subjects must have primary tumor locations in the
                  oropharynx, oral cavity, hypopharynx, or larynx. Primary tumor sites of
                  nasopharynx, maxillary sinus, paranasal, and unknown primary are excluded.

               -  Non-small cell lung cancers: Subjects with a known EGFR sensitizing (activating)
                  mutation or an ALK fusion are excluded.

          3. Subject must have received, been intolerant to, or is ineligible for standard therapy
             (per local guidelines and approvals) or have a malignancy for which there is no
             approved therapy considered standard of care.

          4. Age 18 years and older.

          5. Has an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1.

          6. Has measurable disease by iRECIST (solid tumors) or RECIL 2017 (lymphoma). Refer to
             Appendix Sections 16.6 and 16.7 for details on criteria of measurable disease.

          7. Has life expectancy of greater than 12 weeks.

          8. Laboratory values must meet the following criteria. Laboratory parameter Threshold
             value

               -  Absolute lymphocyte count (ALC) ≥ 0.8 x 109/liter (L)

               -  Absolute neutrophil count (ANC) ≥ 1.5 x 109/L without growth factor support

               -  Platelet count ≥ 50 x 109/L

             Laboratory parameter Threshold value

               -  Hemoglobin (Hgb) > 9.0 g/dL with no blood transfusions for at least 5 days prior
                  to D1 of investigational product (IP; SL-279252)

               -  Creatinine clearance (CrCl) ≥ 30 milliliter (mL)/min (modified Cockcroft-Gault)

               -  ALT/AST ≤ 3 x ULN

               -  Total bilirubin ≤ 1.5 x ULN; subjects with isolated indirect hyperbilirubinemia
                  are permitted if direct bilirubin ratio is <35% and total bilirubin is ≤ 3.0 x
                  ULN

               -  Left ventricular ejection fraction (LVEF) by echocardiogram (ECHO) ≥ lower limit
                  of normal (LLN) per institutional threshold. If LLN is not defined for a given
                  institution, then ejection fraction must be ≥50 %.

          9. Females of child bearing potential (FCBP) must have a negative serum or urine
             pregnancy test within 72 hours of D1 of IP. NOTE: FCBP unless they are surgically
             sterile (i.e., have undergone a complete hysterectomy, bilateral tubal
             ligation/occlusion, bilateral oophorectomy or bilateral salpingectomy), have a
             congenital or acquired condition that prevents childbearing or are naturally
             postmenopausal for at least 12 consecutive months (see Appendix Section 16.2 for
             additional details). Documentation of postmenopausal status must be provided. FCBP
             should use an acceptable method of contraception (see Appendix Section 16.2) to avoid
             pregnancy during treatment and for 30 days (which exceeds 5 half-lives) after the last
             dose of IP. FCBP must start using acceptable contraception at least 14 days prior to
             D1 of IP.

         10. Male subjects with female partners must have azoospermia from a prior vasectomy or
             underlying medical condition or agree to use an acceptable method of contraception
             during treatment and for 30 days (which exceeds 5 half-lives) after last dose of
             SL-279252 (see Appendix Section 16.2). Male subjects of reproductive potential must
             start using acceptable contraception at least 14 days prior to D1 of treatment with
             SL-279252 as per Appendix Section 16.2.

         11. All AEs resulting from prior anti-cancer immunotherapy have resolved (NOTE: exceptions
             include alopecia, vitiligo, and endocrinopathies adequately treated with hormone
             replacement).

             • Subjects that were discontinued from prior PD-1/L1 therapy due to immune-related
             adverse events are not eligible

         12. Recovery from toxicities from prior anti-cancer treatments including surgery,
             radiotherapy, chemotherapy or any other anti-cancer therapy to baseline or ≤ Grade 1.
             (NOTE: Low-grade toxicities (e.g., alopecia, ≤ Grade 2 lymphopenia, ≤ Grade 2
             hypomagnesemia, ≤ Grade 2 neuropathy) may be allowed at the discretion of the
             investigator if considered clinically insignificant. Please consult the Sponsor
             Medical Monitor to discuss these cases).

        Exclusion Criteria:

        Participants are excluded from the study if any of the following criteria apply:

          1. Has received more than two prior checkpoint inhibitor containing treatment regimens
             (regimen refers to either monotherapy or combination immunotherapies) or has had prior
             treatment with an OX40 agonist.

             • Prior PD-1/L1 therapy is not required.

          2. Refractory to last PD-1/L1 inhibitor-based therapy which is defined as disease
             progression within 3 months of treatment initiation.

             • Subjects must have had clinical benefit (stable disease or response) to last PD-1/L1
             inhibitor-based therapy for at least three months to be eligible.

          3. Any anti-cancer therapy within the time intervals noted below prior to first dose (D1)
             of SL-279252.

             Therapy Washout period Chemotherapy 3 weeks Hormonal therapy 3 weeks PD-1/L1 inhibitor
             and other immunotherapies not otherwise specified 3 weeks Tumor vaccine 4 weeks
             Cell-based therapy 8 weeks Other mAbs or biologic therapies 3 weeks Major surgery 2
             weeks Radiation (except palliative intent which does not require washout) 2 weeks

          4. Concurrent chemotherapy, immunotherapy, biologic or hormonal therapy is prohibited.
             Concurrent use of hormones for non-cancer related conditions is acceptable.

          5. Use of corticosteroids or other immunosuppressive medication, current or within 14
             days of D1 of IP with the following exceptions (i.e., the following are allowed during
             treatment with or within14 days of D1 of IP):

               -  Topical, intranasal, inhaled, ocular, intraarticular corticosteroids

               -  Physiological doses of replacement steroid (e.g., for adrenal insufficiency)
                  provided ≤ 10 mg/day of prednisone or equivalent

               -  Steroid premedication for hypersensitivity reactions (HSRs; e.g., reaction to IV
                  contrast)

          6. Receipt of live attenuated vaccine within 28 days of D1 of IP.

          7. Active or documented history of autoimmune disease (autoimmune disease does not refer
             to irAEs; for irAEs see inclusion criteria #11). Exceptions include Type I diabetes,
             vitiligo, alopecia areata or hypo/hyperthyroidism.

          8. Active pneumonitis (i.e. drug-induced, idiopathic pulmonary fibrosis,
             radiation-induced, etc.).

          9. Ongoing or active infection (e.g., no systemic antimicrobial therapy for treatment of
             infection within 5 days of D1 of IP).

         10. Symptomatic peptic ulcer disease or gastritis, active diverticulitis, other serious
             gastrointestinal (GI) disease associated with diarrhea within 6 months of D1 of IP.

         11. Clinically significant or uncontrolled cardiac disease including any of the following:

               -  Myocarditis

               -  Unstable angina within 6 months from D1 of IP

               -  Acute myocardial infarction within 6 months from D1 of IP

               -  Uncontrolled hypertension

               -  New York Heart Association (NYHA) Class II, III or IV congestive heart failure

               -  Clinically significant (symptomatic) cardiac arrhythmias (e.g., sustained
                  ventricular tachycardia, second- or third- degree atrioventricular block without
                  a pacemaker, circulatory collapse requiring vasopressor or inotropic support, or
                  arrhythmia requiring therapy)

         12. Untreated central nervous system (CNS) or leptomeningeal metastases. Subjects with
             treated CNS metastases must have completed definitive treatment (radiotherapy and/or
             surgery) > 2 weeks prior to D1 of IP and no longer require steroids.

         13. Women who are breast feeding.

         14. Psychiatric illness/social circumstances that would limit compliance with study
             requirements and substantially increase the risk of AEs or compromised ability to
             provide written informed consent.

         15. Another malignancy that requires active therapy and that in the opinion of the
             investigator and Sponsor would interfere with monitoring of radiologic assessments of
             response to IP.

         16. Has undergone allogeneic stem cell transplantation or organ transplantation.

         17. Known history or positive test for human immunodeficiency virus, or positive test for
             hepatitis B (positive for hepatitis B surface antigen [HBsAg]) or hepatitis C virus
             ([HCV]; if HCV antibody (Ab) test is positive check for HCV ribonucleic acid [RNA]).

               -  (NOTE: Hepatitis B virus (HBV): Subjects who are hepatitis B core antibody
                  [HBcAb] positive, but HBsAg negative are eligible for enrollment. HCV: Subjects
                  who are HCV Ab positive, but HCV RNA negative are eligible for enrollment).