Inclusion Criteria:

          -  Age ≥ 12 years and weight ≥ 40 kg.

          -  Diagnosis of advanced or recurrent, histologically or cytologically confirmed, solid
             malignancy that is either metastatic or unresectable. At time of enrollment, subjects
             must have progressed on, be intolerant of, refuse, or ineligible for, all available
             standard of care therapies.

          -  Subjects must demonstrate measurable disease per Response Evaluation Criteria in Solid
             Tumors (RECIST) v1.1, with the exception of castration-resistant prostate cancer
             (CRPC) who should have progression based on the PCWG 3.0 criteria

          -  Karnofsky ≥70% for over ≥16 years old and Lansky ≥70% for under 16 years old,
             equivalent to Eastern Cooperative Oncology Group (ECOG) performance status grade 0 or
             1

          -  Willingness to provide tumor biopsies of assessible lesions on and off treatment (Dose
             expansion cohort only). Optional for patients <18 years of age.

          -  Able to swallow and retain orally administered medication.

          -  Patients must have normal organ and marrow function

          -  Ability to understand and the willingness to sign a written informed consent document.

        Exclusion Criteria:

          -  Subjects with Ewing Sarcoma. See NCT03600649, Protocol Number: SALA-002-EW16.

          -  Subjects with primary central nervous system tumors

          -  Patients who have not recovered to grade 1 or baseline from adverse events related to
             prior therapy excluding lymphopenia, alopecia, peripheral neuropathy and ototoxicity,
             which are excluded if ≥ CTCAE grade 3 (Version 5.0).

          -  Patients who are receiving any other investigational agents.

          -  Prior therapy with LSD1 targeted agents including monoamine oxidases for cancer
             therapy.

          -  Prior systemic anti-cancer treatment (chemotherapy, biologic therapy [ie. small
             molecular inhibitors, monoclonal antibodies]) within 21 days prior to Cycle 1 Day 1.

          -  Prior therapy with immunotherapy such as a checkpoint inhibitor, cellular therapy or
             vaccine therapy within 28 days prior to Cycle 1 Day 1. Patients must have recovered
             from any immune-related adverse events to grade 1 or baseline and require ≤ 10 mg of
             prednisone equivalents daily. Patients with immune-related hypothyroidism and/or
             hypoadrenalism may enroll while on thyroid or hydrocortisone replacement therapy,
             respectively.

          -  Prior small port palliative radiotherapy within 14 days or 42 days from definitive
             local control radiation (any dose greater than 50Gy).

          -  Anti-androgen therapies for prostate cancer, such as bicalutamide, within 4 weeks
             prior to enrollment. Second-line hormone therapies such as enzalutamide, abiraterone,
             or orteronel within 2 weeks prior to enrolment. Subjects with prostate cancer should
             remain on luteinizing hormone releasing hormone (LHRH) agonists or antagonists.
             Subjects with prostate cancer may also remain on low-dose prednisone or prednisolone
             up to 10 mg/day

          -  Prior therapy with long acting myeloid growth factor within 14 days or 7 days from a
             short acting myeloid growth factor.

          -  Participation in a prior investigational study within 30 days prior to Cycle 1 Day 1.

          -  Patients with progressive or symptomatic brain metastases. Patients with brain
             metastases may be included in this trial as long as the brain metastases have received
             definitive treatment and are stable (i.e., no evidence of progression). The brain
             metastases must be stable for a minimum of 6 weeks.

          -  Patients must have discontinued anti-seizure medications and steroids, except for
             physiologic steroid dosing (≤10 mg/day of prednisone equivalents).

          -  Patients currently receiving any of the following substances and cannot be
             discontinued 14 days prior to Cycle 1 Day 1: Moderate or strong inhibitors or inducers
             of major CYP isoenzymes, including grapefruit, grapefruit hybrids, pomelos,
             star-fruit, and Seville oranges; Moderate or strong inhibitors or inducers of major
             drug transporters; Substrates of CYP3A4/5 with a narrow therapeutic index

          -  Uncontrolled concurrent illness including, but not limited to: ongoing or active
             infection; transfusion dependent thrombocytopenia or anemia; psychiatric
             illness/social situations that would limit compliance with study requirements

          -  Clinically significant, uncontrolled heart disease and/or cardiac repolarization
             abnormality, including any of the following: symptomatic congestive heart failure;
             Left Ventricular Ejection Fraction (LVEF) ≤ 50%; unstable angina pectoris or cardiac
             arrhythmia; baseline QTcF (Fridericia) ≥ 450 milliseconds; Long QT syndrome or family
             history of idiopathic sudden death or congenital long QT syndrome

          -  Any major surgery within 21 days prior to Cycle 1 Day 1.

          -  Pregnant and breastfeeding women

          -  Women of child-bearing potential and men must agree to use adequate contraception
             (hormonal or barrier method of birth control; abstinence) prior to study entry and for
             the duration of study participation.

          -  HIV-positive patients on combination antiretroviral therapy are ineligible because of
             the potential for pharmacokinetic interactions with SP-2577. In addition, these
             patients are at increased risk of lethal infections when treated with
             marrow-suppressive therapy.