Key Inclusion Criteria:

          1. Able to provide informed consent

          2. Age 18 on day of signing informed consent form (ICF) or of the legal age of consent in
             the jurisdiction in which the study is taking place

          3. Advanced or metastatic, unresectable tumors (other than patients with tumors of the
             brain or central nervous system) who have experienced disease progression

               -  Part A: NSCLC, CRC, ovarian cancer, endometrial cancer, thyroid cancer, melanoma,
                  pancreatic cancer, and other)

               -  Part B: Group 1: NSCLC, Group 2: endometrial cancer, Group 3: Tumor types of
                  interest based on preliminary anti-tumor activities observed in Part A

          4. Must have archival tumor tissue or agree to tumor biopsy

          5. Measurable disease per RECIST 1.1

          6. Eastern Cooperative Oncology Group performance status of less than or equal to 1

          7. Life expectancy is greater than 12 weeks at the of signing ICF.

          8. Adequate organ function and no transfusion within 14 days of first dose.

          9. Females are of non-child bearing potential or willing to use contraception.

         10. Males vasectomized or agree to use contraception.

        Key Exclusion Criteria:

          1. Central Nervous System metastasis

          2. Any retinal pathology considered to be a risk factor for central serous retinopathy

          3. History of glaucoma

          4. Active parathyroid disorder or history of malignancy associated hypercalcemia

          5. Clinically significant cardiac disease within the past 6 months of signing ICF.

          6. LVEF less than 50%

          7. Abnormal QT interval at Screening

          8. Severe uncontrolled systemic disease

          9. HIV

         10. Clinically significant active or known history of liver disease. (Hepatitis B and
             Hepatitis C)

         11. Hemorrhage or bleeding event at NCI-CTCAE v5.0 Grade 3 or higher within 28 days of
             first dose.

         12. history of or ongoing Von Willebrand disease and/or other past or present bleeding
             disorders

         13. Increased serum calcium

         14. Inability to swallow oral medications

         15. Ongoing radiation therapy or radio-cytotoxic therapy within prior 4 weeks. No
             chemotherapy, immunotherapy, biologic therapy, hormonal, or molecular targeted therapy
             within prior 2 weeks

         16. Concomitant systemic or glucocorticoid therapy within 2 weeks

         17. Major surgical procedure or significant traumatic injury within 4 weeks prior to first
             dose or anticipates need for major surgery while on study

         18. Concomitant medicines that are strong CYP3A inhibitors

         19. History of toxicity from another RAF, MEK, ERK inhibitor requiring discontinuation of
             treatment from these drugs

         20. Underlying medical conditions in investigator's opinion to be unfavorable to be a part
             of the study

         21. Has been administered a live vaccine within 4 weeks (28 days) of initiation of study
             treatment. NOTE: injectable seasonal vaccines for influenza and COVID-19 are generally
             inactivated vaccines and are allowed. Intranasal vaccines are live vaccines and are
             not allowed.

        NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.