Inclusion Criteria:

          1. Patient must have previously met pre-transplantation eligibility.

          2. Patient has received an allogeneic transplant for AML or MDS.

          3. Any standard (non-study) conditioning [MAC (myeloablative conditioning), RIC (reduced
             intensity conditioning), or NMA (non-myeloablative conditioning)] will be permitted.

          4. Patient is ≥ 30 days and ≤ 100 days from hematopoietic cell infusion.

          5. Patient is in complete remission after the transplant and has achieved engraftment. .

          6. Patients who have developed grades II-IV acute GVHD (graft versus host disease) will
             be allowed to initiate maintenance therapy based on the following criteria:

          7. Females must either:

             Be of non-childbearing potential postmenopausal (defined as at least 1 year without
             menses) prior to screening, or documented as surgically sterilized (e.g., hysterectomy
             or tubal ligation) at least 1 month prior to the screening visit Or, if of
             childbearing potential, Agree not to try to become pregnant during the study and for 6
             months after the final study drug administration And have a negative serum pregnancy
             test at screening And, if heterosexually active, agree to consistently use highly
             effective contraception per locally accepted standards in addition to a barrier method
             starting at screening and throughout the study period and for 6 months after final
             study drug administration.

          8. Females must agree not to breastfeed or donate ova throughout the study drug treatment
             period and for 6 months after the final study drug administration.

          9. Males (even if surgically sterilized), and their partners who are women of
             childbearing potential must be using highly effective contraception in addition to a
             barrier method throughout the study drug treatment period.

         10. Males must not donate sperm throughout the study drug treatment period.

         11. Agrees not to participate in another interventional study while on treatment.

         12. Karnofsky Performance Status 70 or greater is required.

        Exclusion Criteria:

          1. Prior participation in an APR-246 study.

          2. Use of umbilical cord blood donor and stem cell source.

          3. Patient has uncontrolled infection.

          4. Use of investigational agent within 14 days of pre-HSCT screening or anytime
             thereafter.

          5. Use of hypomethylating agent, cytotoxic chemotherapeutic agents, or experimental
             agents (agents that are not commercially available) for the treatment of MDS or AML
             within 14 days of the first day of pre-HSCT screening or anytime thereafter.

          6. Patient has used experimental therapy for acute GVHD at any time post-transplant.

          7. Patient requires treatment with supplemental oxygen not including usage of
             non-invasive CPAP (continuous positive airways pressure) at night.

          8. Patient has any of the following cardiac abnormalities (as determined by treating
             physician):

               1. Myocardial infarct within six months prior to registration

               2. New York Heart Association Class II or worse heart failure or known LVEF (left
                  ventricular ejection fraction) < the institution LLN (lower limit normal)

               3. A history of familial long QT syndrome

               4. Electrocardiographic evidence of acute ischemia at screening

               5. Symptomatic atrial or ventricular arrhythmias not controlled by medications

               6. QTc ≥ 470 ms calculated from a mean of 3 ECG (electrocardiogram) readings using
                  Fridericia's correction (QTcF = QT/RR0.33)

               7. Bradycardia (<40 bpm) at screening