Inclusion Criteria:

          1. Patients must be willing to sign an informed consent.

          2. Male or female patients aged 18 to 70 years .

          3. Estimated survival of ≥ 12 weeks.

          4. Pathological sections with positive expression of NY-ESO-1, Mesothelin, EGFRvIII and
             DR5 was confirmed by biopsy IHC test within 12 months.If NY-ESO-1 is positive
             expression ,positive HLAA*0201 is required at the same time.

          5. Solid tumor must have at least one measureable disease according to RECIST 1.1.

          6. Routine blood test#hemoglobin>=90 g/L; platelet>=50×10^9/L.

          7. Liver function:ALT and AST≤2.5 times upper limits of normal (If the tumor infiltration
             is the main cause of abnormal liver function ,ALT and AST≤5 times upper limits of
             normal); bilirubin<2.0 mg/dL.

          8. Renal function:BUN: 9-20mg / dl; serum creatinine≤ 1.5 times upper limits of normal;
             endogenous creatinine clearance rate≥50 ml/min .

          9. Negative serum antibody for EBV, CMV, HIV , syphilis, HBVa nd HCV.

         10. Cardiac function: stable hemodynamic and left ventricular ejection fraction
             (LVEF)>=55%.

         11. ECOG score:0-1.

         12. Adequate venous access for apheresis, and no other contraindications for leukapheresis
             .

         13. Women of child-bearing age must have evidence of negative pregnancy test. Subjects of
             reproductive potential must agree to use acceptable birth control methods within 1
             year after treatment, as described in protocol.

         14. Subjects with hypertension/diabetes must be stable blood pressure/blood glucose or
             ≤CTCAE 1 level 2 weeks before the screening.

        In addition to the above criteria for inclusion, the following criteria shall be met
        according to the indications:

        Patients with glioblastoma：

          1. First disease progression or disease recurrence (≥ 1 cm and ≤ 5 cm) of a
             supratentorial WHO grade IV malignant glioma (GBM or gliosarcoma) based on imaging
             studies with measurable disease.

          2. EGFRvIII, the target antigen, must be identified on tumor tissue by IHC or PCR, i.e.
             EGFRvIII positive via pathology report.

          3. Insensitivity to chemoradiotherapy or chemoradiotherapy failure after operation
             molecular pathology.

          4. Refused to receive radiotherapy or chemotherapy treatment.

        Patients with liver cancer

          1. DR5 or EGFRvIII positive via pathology report.

          2. Untreatable by surgery ; Or postoperative recurrence ;Or no effective treatment.

          3. Liver function：child-pugh A grade or child-pugh B grade.

        Patients with gastric cancer

          1. Mesothelin positive via pathology report.

          2. The pathological stage：IIIA～IV.

          3. chemoradiotherapy failure

          4. Refused or unable to get surgery.

        Patients with esophageal cancer

          1. NY-ESO-1 positive via pathology report and HLA-A*0201 positive in blood.

          2. Refuse or unable to get surgery.

          3. Postoperative recurrence or chemoradiotherapy failure.

        Exclusion Criteria:

          1. ECOG≥2.

          2. malignant tumor cells with T cell origin via pathology test.

          3. Organ failure: stage III or IV congestive heart failure; Renal failure and uremia;
             respiratory failure; disturbance of consciousness.

          4. Acute or chronic GVHD after allogeneic hematopoiesis; Or being treated for GVHD; Or
             hormone or immunosuppressant used within 30 days

          5. steroid hormoneswere used before and after blood collection and infusion

          6. Patients with HIV infection or active hepatitis

          7. Uncontrolled active infection.

          8. Enrolled to other clinical study in the last 4 weeks.

          9. Patients with systemic auto-immune disease or immunodeficiency.

         10. Patients with neuropathy or psychosis, including dementia or epilepsy, or history of
             psychotropic substance abuse, or other substantial lesions that may increase central
             neurotoxicity.

         11. Concomitant with the second tumor or other malignant tumors.

         12. Patients with bone metastases are at risk of a pathological fracture resulting in
             paraplegia or life threatening.

         13. Live attenuated vaccine was administered within 4 weeks prior to blood collection.

         14. Blood oxygen saturation is maintained by oxygen inhalation.

         15. Received major surgery within 2 weeks prior to screening ;Or Plan to receive surgery
             during study or within 2 weeks after injection.

         16. Other patients that researchers considered unsuitable for inclusion.