Inclusion criteria applicable to all study treatment modules (Groups A/B):

          -  Non-Small Cell Lung Cancer (NSCLC) with the following features:

               -  Locally advanced or metastatic disease (i.e. advanced NSCLC) not amenable to
                  curative surgery or radiotherapy at study entry.

               -  Histologically or cytologically confirmed adenocarcinoma of the lung harbouring
                  epidermal growth factor receptor (EGFR) mutation(s) known to be associated with
                  tyrosine kinase inhibitors (TKI) sensitivity at diagnosis.

               -  Received only 1 line of therapy, with single-agent osimertinib, for advanced
                  NSCLC, with clinical benefit as judged by investigator discretion.

               -  Evidence of radiological disease progression on first-line monotherapy with
                  osimertinib 80mg once daily.

          -  Suitable for a mandatory biopsy defined as having an accessible tumour and a stable
             clinical condition that will allow the patient to tolerate the procedure. The biopsy
             should be performed within 60 days prior to the planned first dose of study treatment.

          -  Patients must have measurable disease per Response Evaluation Criteria In Solid
             Tumours (RECIST) 1.1.

          -  World Health Organisation (WHO) performance status 0 or 1 with no deterioration
             between screening and the first dose of study treatment.

          -  A minimum life expectancy of 12 weeks.

          -  Ability to swallow and retain oral medication and have adequate venous access.

          -  Provision of archival tumour tissue for exploratory research (if such tissue/sample is
             available, its provision is mandatory).

          -  Ability and willingness to comply with the study and follow-up.

          -  Adequate coagulation parameters, defined as: International Normalisation Ratio (INR)
             <1.5 × upper limit of normal (ULN) and activated partial thromboplastin time <1.5 ×
             ULN unless patients are receiving therapeutic anti-coagulation which affects these
             parameters.

          -  Patients with known tumour thrombus or deep vein thrombosis are eligible if clinically
             stable on low molecular weight heparin, factor Xa inhibitors or thrombin inhibitors
             for ≥2 weeks.

          -  Willingness to adhere to the study treatment-specific contraception requirements.

        Exclusion Criteria applicable to all study treatment modules (Groups A/B):

          -  Patients whose disease has progressed within the first 3 months of osimertinib
             treatment

          -  Patients must not have experienced a toxicity(-ies) that led to permanent
             discontinuation or dose reduction of prior osimertinib or have any unresolved
             toxicities from prior osimertinib treatment greater than CTCAE (Common Terminology
             Criteria for Adverse Event) Grade 1 at the time of starting study treatment

          -  Patients must not have discontinued osimertinib >60 days prior to the first dose of
             study treatment

          -  Prior or concurrent treatment with any systemic anticancer therapy for locally
             advanced/metastatic NSCLC including chemotherapy, biologic therapy, immunotherapy, or
             any investigational drug (exceptions do apply)

          -  Major surgery within the 28 days prior to the first dose of study treatment except:

               -  After minor surgery, at least 7 postoperative days must elapse before study
                  treatment is initiated.

               -  After placement of vascular access, this waiting period is not required.

          -  Receipt of live attenuated vaccine within 30 days prior to the first dose of study
             treatment.

          -  Treatment with warfarin/coumarin analogues within 7 days prior to the first dose of
             study treatment

          -  Diagnosis of small cell lung cancer (SCLC) or squamous cell carcinoma (SCC)

          -  Spinal cord compression, symptomatic and unstable brain metastases, except for those
             patients who have completed definitive therapy, are not on steroids, have a stable
             neurologic status for at least 2 weeks after completion of the definitive therapy and
             steroids.

          -  Allogenic organ transplantation

          -  As judged by the investigator, any evidence of severe or uncontrolled systemic disease
             or evidence of any other significant clinical disorder or laboratory finding that
             makes it undesirable for the patient to participate in the study.

          -  History of another primary malignancy except for:

               -  Malignancy treated with curative intent and with no known active disease for at
                  least 2 years before the first dose of study treatment, and with low potential
                  risk for recurrence.

               -  Adequately treated nonmelanoma skin cancer or lentigo maligna without evidence of
                  disease

               -  Adequately treated carcinoma in situ without evidence of disease.

               -  Localised non-invasive primary disease under surveillance.

          -  Active infection, including infections with hepatitis B virus, hepatitis C virus, or
             human immunodeficiency virus (exceptions apply)

          -  Pregnancy or breastfeeding in female patients

          -  Any of the following cardiac criteria:

               -  Any clinically important abnormalities in rhythm, conduction, or morphology of
                  resting ECG

               -  Unstable atrial fibrillation or unstable cardiac arrhythmia with a ventricular
                  rate >100 bpm on an ECG at rest.

               -  Uncontrolled hypertension

               -  Uncontrolled angina or acute coronary syndrome within 6 months prior to
                  screening.

               -  At risk for brain perfusion problems or stroke, or transient ischemic attack in
                  the last 6 months prior to screening

               -  Symptomatic heart failure

               -  Prior or current cardiomyopathy.

               -  Severe valvular heart disease

          -  Inadequate bone marrow reserve or organ function

          -  Creatinine clearance <50 mL/min, calculated by Cockcroft-Gault equation