Inclusion Criteria:

          -  PRE-REGISTRATION ELIGIBILITY CRITERIA

          -  Provide adequate tissue for PD-L1 testing

             * Fresh tissue or archival tissue can be used. Sample must be at least core needle
             biopsy. Fine needle aspiration is not adequate. This specimen submission is mandatory
             prior to registration as results will be used for stratification

          -  REGISTRATION ELIGIBILITY CRITERIA

          -  • Biopsy-proven advanced cutaneous squamous cell carcinoma. Advanced disease is
             defined as either metastatic cutaneous squamous cell carcinoma or locally advanced
             cutaneous squamous cell carcinoma not amenable to curative surgical resection, or the
             patient declines surgical resection

          -  The patient must have at least one lesion that is measurable disease based on Response
             Evaluation Criteria in Solid Tumors (RECIST) 1.1

          -  If patient received major surgery, they must have recovered adequately from the
             toxicity and/or complications from the intervention prior to starting therapy

          -  This study involves an investigational agent whose genotoxic, mutagenic and
             teratogenic effects on the developing fetus and newborn are unknown. Therefore, for
             women of childbearing potential only, a negative urine or serum pregnancy test done =<
             7 days prior to registration is required

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0-2

          -  If human immunodeficiency virus (HIV) positive the HIV viral load must be < 200
             copies/mL and CD4 count > 200. If an HIV positive patient is on highly active
             antiretroviral therapy (HAART) the patient must have been so for > 4 weeks

          -  Absolute neutrophil count (ANC) >= 1,500/mm^3

          -  Platelet count >= 100,000/mm^3

          -  Calculated creatinine clearance >= 30 mL/min

          -  Total bilirubin =< 1.5 x upper limit of normal (ULN)

          -  Aspartate aminotransferases (AST) / alanine aminotransferase (ALT) =< 2.5 x upper
             limit of normal (ULN)

        Exclusion Criteria:

          -  Patients who received prior treatment with cetuximab as palliative treatment for
             advanced cutaneous squamous cell carcinoma (cSCC) are excluded. Patients that received
             cetuximab based chemoradiation (either definitive or adjuvant) as prior treatment for
             locally advanced disease are eligible as long as the last dosage was given >= 6 months
             prior to registration

          -  Patients who received prior cetuximab and had a severe infusion reaction requiring
             discontinuation of cetuximab are excluded

          -  Patients treated with prior anti-PD-1 or anti-PD-L1 monoclonal antibodies (mAbs) are
             excluded

          -  Patients cannot have received treatment with radiation or chemotherapy including
             another investigational agent within 2 weeks of registration. Other than as stated
             above for cetuximab there are no limits on the number of lines of other therapies
             given for advanced cSCC

          -  Patients with a "currently active" second malignancy will be excluded with the
             exception of other non-melanoma skin cancers or cervical carcinoma in situ. Patients
             are not considered to have a "currently active" malignancy if they have completed
             therapy and are free of disease for 3 years

          -  No history of the following:

               -  Autoimmune disease (including inflammatory bowel disease) with the exception of
                  patients with diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid
                  diseases not requiring immunosuppressive treatment

               -  Non-infectious pneumonitis that required steroids within 5 years

               -  Organ transplant including prior stem cell transplant

               -  Receipt of a live vaccine =< 4 weeks

               -  Cerebral vascular accident/stroke within 6 months of enrollment

               -  Myocardial infarction within 6 months of enrollment

               -  Active unstable angina

               -  Congestive heart failure (>= New York Heart Association Classification class II)

               -  Serious cardiac arrhythmia requiring medication. Whether an arrhythmia is
                  considered "serious" is at the discretion of the investigator

          -  Active infection requiring systemic treatment

          -  Use of immunosuppressive medication =< 7 days of registration, EXCEPT for the
             following:

               -  Intranasal, inhaled, topical steroids, or local steroid injection (e.g.,
                  intra-articular injection)

               -  Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or
                  equivalent

               -  Steroids as premedication for hypersensitivity reactions (e.g., computed
                  tomography [CT] scan premedication)"

          -  Other severe acute or chronic medical conditions including but not limited to immune
             colitis, pulmonary fibrosis or psychiatric conditions including recent (within the
             past year) or active suicidal ideation or behavior; or laboratory abnormalities that
             may increase the risk associated with study participation or study treatment
             administration or may interfere with the interpretation of study results and, in the
             judgment of the investigator, would make the patient inappropriate for entry into this
             study