This research study is a Phase I clinical trial, which tests the safety of an investigational
drug and also tries to define the appropriate dose of the investigational drug to use for
further studies. "Investigational" means that the drug is being studied.
The FDA (the U.S. Food and Drug Administration) has not approved niraparib for this specific
disease but it has been approved for other uses.
Niraparib is a type of drug called a "PARP inhibitor", which blocks DNA (the genetic material
of cells) damage from being repaired or may prevent damage from occurring in the first place.
In cancer treatment, inhibiting PARP may help kill cancer cells by not allowing the cancer
cells to repair its DNA damage or prevent DNA damage from occurring.
This trial is studying people who have triple negative breast cancer because this cancer type
is shown to have DNA repair mechanisms that may benefit from combined PARP inhibitor and
radiation, and may help prevent recurrence of cancers in the chest wall and lymph nodes of
the affected side.
- Males or Females, ≥ 18 years of age.
- Non-metastatic, histologically or cytologically-confirmed TNBC (defined as ER <1%, PR
<1%, her-2-neu 0-1+ by IHC or FISH-negative or as per MD discretion).
- Definitive surgical treatment with breast-conserving surgery or mastectomy and
axillary lymph node evaluation.
- Residual disease in the breast or lymph nodes at the time of definitive surgical
treatment after NAC (any volume of residual disease is permitted; RCB-I to III).
- ECOG Performance status ≤ 1.
- Willingness to discontinue any cytotoxic chemotherapeutic agents, immunotherapy and
biologic therapy at least 2 weeks prior to the start of RT.
- Adequate organ function (assessed within 30 days prior to initiation of protocol
treatment, unless otherwise indicated) as follows:
- Absolute Neutrophil Count (ANC) ≥1500/mm3
- Platelet Count ≥100,000/mm3
- Hemoglobin ≥9.0 g/dL
- Renal Function
- Creatinine Serum ≤ 1.5 mg/dL or
- Creatinine Clearance ≥ 45 mL/mina
- Hepatic Function
- Bilirubin ≤ 1.5 mg/dL
- Aspartate Aminotransferase (AST) ≤ 2.5 x ULNb
- Alanine Aminotransferase (ALT) ≤ 2.5 x ULN
- ULN = upper normal limit of institution's normal range
- If calculated creatinine clearance is < 45mL/min, a 24-hour urine collection for
creatinine clearance may be performed
- Subjects with documented Gilbert's disease may have bilirubin up to 2.5 mg/dL
- Female participants have a negative urine or serum pregnancy test within 7 days prior
to study treatment if a woman has child-bearing potential, and agrees to abstain from
activities that could result in pregnancy from screening through 180 days after the
last dose of study treatment, or is of non-childbearing potential.
- Non-childbearing potential is defined as follows (by other than medical reasons):
--≥45 years of age and has not had menses for >1 year
- Patients who have been amenorrhoeic for <2 years without history of a
hysterectomy and oophorectomy must have a follicle stimulating hormone value in
the postmenopausal range upon screening evaluation
- Post-hysterectomy, post-bilateral oophorectomy, or post-tubal ligation.
Documented hysterectomy or oophorectomy must be confirmed with medical records of
the actual procedure or confirmed by an ultrasound. Tubal ligation must be
confirmed with medical records of the actual procedure, otherwise the patient
must be willing to use 2 adequate barrier methods throughout the study, starting
with the screening visit through 180 days after the last dose of study treatment.
See Section 220.127.116.11 for a list of acceptable birth control methods. Information
must be captured appropriately within the site's source documents. Note:
Abstinence is acceptable if this is the established and preferred contraception
for the patient.
- Male participant agrees to use an adequate method of contraception (see Section
18.104.22.168) for a list of acceptable birth control methods) starting with the first dose
of study treatment through 90 days after the last dose of study treatment. Note:
Abstinence is acceptable if this is the established and preferred contraception for
- Participant must agree not to breastfeed during the study or for 30 days after the
last dose of study treatment.
- Participant receiving corticosteroids may continue as long as their dose is stable for
at least 4 weeks prior to initiating protocol therapy.
- Participant must agree not to donate blood during the study or for 90 days after the
last dose of study treatment.
- Ability to swallow (whole) and retain oral medications.
- Written informed consent obtained from subject and ability for subject to comply with
the requirements of the study.
- Dose Cohort 2 only:
- Actual body weight ≥77kg AND
- Platelet count ≥150,000 µL
- Gross residual tumor or positive margins after surgery that is un-excised (excluding
positive margins at the chest wall or skin where no additional breast tissue can be
- Complete pathologic response to NAC (RCB-0).
- Receipt of PARP inhibitor at any time prior to study enrollment.
- Pregnant or expecting to conceive within the projected duration of the trial, starting
with screening visit through 180 days after the last dose of trial treatment.
- Prior history of radiation therapy to the ipsilateral breast and/or regional nodes is
not allowed (prior RT to other sites that was completed ≥ 1 week prior to Day 1 of
protocol therapy, or if prior RT encompassed >20% of the bone marrow it was completed
≥ 2 weeks prior to Day 1 of protocol therapy, is permitted).
- Major surgery ≤ 3 weeks prior to initiating protocol therapy and participant must have
recovered from any surgical effects.
- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to niraparib, or its components or excipients.
- Concomitant anti-neoplastic treatment is not allowed during protocol treatment and
should be completed at least 2 weeks prior to commencement of protocol treatment, with
resolution of associated acute toxicities. Bisphosphonates are permitted without
restriction even during protocol treatment.
- Significant comorbidity: Patients with clinically significant and uncontrolled major
disease or disorder that could exacerbate potential toxicities, confound safety
assessments, require excluded therapy for management, or limit study compliance.
- Treatment with investigational therapy within ≤ 4 weeks, or within a time interval
less than at least five half-lives of the investigational agent, whichever is shorter,
prior to initiating protocol therapy. Patients may not be simultaneously enrolled in
any interventional clinical trial.
- Unresolved toxicity from other agents. Patients with unresolved CTCAE v5 Grade 2 or
greater toxicity, with the exception of alopecia and anemia, from prior administration
of another investigational drug and/or anti-cancer treatment are not eligible.
- Known grade 3 or 4 anemia, neutropenia, or thrombocytopenia that persisted > 4 weeks
and was related to the most recent chemotherapy treatment.
- Participant must not have received a transfusion (platelets or red blood cells) ≤ 4
weeks prior to initiating protocol therapy.
- Participant must not have received colony-stimulating factors (e.g. granulocyte
colony-stimulating factor, granulocyte macrophage colony-stimulating factor, or
recombinant erythropoietin) within 4 weeks prior to initiating protocol therapy.
- Prior malignancy within 5 years of study enrollment.
- Scleroderma and systemic lupus erythematosis.
- Known p53 germline mutations.
- Known history of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).
- Known symptomatic brain or leptomeningeal metastases.
- Dose Cohort 2 only:
- Actual body weight < 77kg OR
- Platelet count < 150,000 µL