Inclusion Criteria:

        For dose escalation with ORIN1001 alone:

        -Male or female with advanced solid tumors for which no effective standard of care
        treatments are available

        For dose escalation with ORIN1001 in combination with Abraxane:

        -Males or females with relapsed refractory metastatic breast cancer (TNBC or ER+, HER2-)
        must have progressed through at least 2 lines of therapy and for whom there are no
        available therapies that confer a clinical benefit

        For dose expansion:

        a. Males or females with relapsed refractory metastatic breast cancer including:

          1. TNBC (i.e. estrogen receptor (ER)-, progesterone receptor-, and human epidermal growth
             factor receptor 2 [HER2]-)

          2. ER+ HER2- breast cancer

        Inclusion Criteria for Dose Escalation and Dose Expansion

          1. Adults aged ≥ 18 years

          2. Eastern Cooperative Oncology Group (ECOG) performance status 0-2

          3. Life expectancy of 3-4 months

          4. Have at least one measurable lesion per RECIST 1.1

          5. Have adequate organ function, including all of the following:

               1. Adequate bone marrow reserve as defined by: ANC≥1.0 x 10 9/L; platelet count ≥75
                  x 10 9/L; hemoglobin ≥9 g/dL

               2. Hepatic: total bilirubin ≤2 x ULN, transaminases (AST/SGOT and/or ALT/SGPT) ≤ 3X
                  ULN;alkaline phosphatase ≤ 5 x ULN

               3. Renal: 24-hour creatinine clearance ≥ 30 mL/min calculated

          6. Adequate tissue sample from either archival tumor tissue or fresh biopsy of tumor at
             the screening for tumor genotyping.

          7. Male subjects must be surgically sterile or must agree to use physician approved
             contraception for 7 days prior to the first study drug administration to 30 days after
             the last dose of study treatment.

          8. Women of childbearing potential must have negative serum pregnancy test within 14 days
             prior the first administration of study drug and agree to use physician-approved
             contraception from 30 days prior to the first study drug administration to 30 days
             following the last study drug administration.

          9. Ability to understand and willingness to sign an informed consent prior to any study
             specific procedures.

         10. Resolution of all toxicities (except alopecia) from prior therapy to ≤ Grade 1 (CTCAE
             v5)

        Exclusion Criteria:

          1. Does not meet inclusion criteria

          2. Received any of the following within the specified time frame prior to the first
             administration of study drug:

             i. Excluding those with a history of coagulopathy ii. Excluding those who require
             concurrent use of anti-coagulants or anti-platelet medication, with exception of
             aspirin doses ≤ 81 mg/day, prophylaxis subcutaneous (SC) heparin or SC low-molecular
             weight heparin for deep vein thrombosis (DVT) prophylaxis or heparin flushes to
             maintain IV catherer patency iii. Excluding subjects that have Prothrombin time
             (PT)/international normalized ratio (INR) or activated partial thromboplastin time
             (aPTT) >1.5 x ULN b.Prior chemotherapy or other systemic anticancer therapy within 3
             weeks or 5 times the plasma half-life of the drug, whichever is shorter; c.Prior
             radiotherapy within 2 weeks; d.Major surgery within 2 weeks; e.Prior treatment with
             investigational drugs within 4 weeks; f. Myocardial infarction, uncontrolled
             angina,severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence
             of acute ischemia, within 6 months prior to the fist dose of study drug

          3. Greater than Class II heart failure using New York Heart Association (NYHA) criteria

          4. The subject has uncontrolled human immunodeficiency virus (HIV) infection or active
             hepatitis B or C infection or other known active and/or uncontrolled infection

          5. Active autoimmune disease that is not appropriately controlled with treatment

          6. Active malignancy with the exception of:

               1. adequately treated basal cell carcinoma, squamous cell carcinoma, or in situ
                  cervical cancer

               2. adequately treated stage I cancer from which the subject is currently in
                  remission, or

               3. any other cancer from which the subject has been disease-free for ≥3 years;

          7. Any serious uncontrolled medical or psychological disorder that would impair the
             ability to receive protocol therapy

          8. Any condition which places the subject at unacceptable risk or confounds the ability
             of the investigator to interpret study data

          9. The subject is pregnant or lactating woman. Any woman who becomes pregnant during the
             study will be withdrawn from the study.

         10. Known active uncontrolled or symptomatic brain metastases. Patients with a history of
             such metastases that have been treated and are stable ≥28 days may be enrolled.
             Patients with no steroid use for at least 2 weeks prior to the time of enrollment are
             permitted.

         11. Failed to respond to the most recent dose of Abraxane and must have been received at
             least 12 months prior to starting treatment.(combination arm only)

         12. Greater than Grade 1 neuropathy (combination arm only)