Inclusion Criteria:

          -  Age >18 years

          -  Males and females

          -  Have a histologically or cytologically confirmed diagnosis of advanced solid tumor

          -  Have advanced or metastatic disease refractory to standard curative or palliative
             therapy or contraindication to standard therapy

          -  Have an ECOG performance status of 0-1

          -  Have a life expectancy of at least 12 weeks (in the opinion of the investigator)

          -  Have adequate bone marrow reserve, liver and renal function

          -  Be reasonably recovered from preceding major surgery and no major surgery within 4
             weeks prior to the start of Day 1 treatment

          -  Have a negative pregnancy test for females with child bearing age at screening and
             should not be breast feeding

          -  Be willing to abstain from sexual activity or practice physical barrier contraception
             from study entry to 3 months after the last day of treatment

        Exclusion Criteria:

          -  Have peripheral sensory neuropathy of Grade 2 or greater at screening

          -  Have known hypersensitivity to chemotherapeutic agents

          -  Have thrombocytopenia with complications including hemorrhage or bleeding > Grade 2
             that required medical intervention or any hemolytic condition or coagulation disorders
             that would make participation unsafe

          -  Have unresolved toxicity from previous treatment or previous investigational agents;
             excluding alopecia

          -  Received investigational agents or systemic anticancer agents (other than neurotoxic
             compounds) within 5 half lives or 28 days, whichever is shorter, prior to Day 1 of
             treatment

          -  Have signs or symptoms of end organ failure, major chronic illnesses other than
             cancer, or any severe concomitant conditions

          -  Have experienced any of the following within the 6-month period prior to screening:
             unstable angina, myocardial infarction or cerebrovascular accident, transient ischemic
             attack, cardiac failure with known ejection fraction less than 40%

          -  Have other severe acute or chronic medical or psychiatric conditions or laboratory
             abnormality that would make the patient inappropriate for enrollment in this study

          -  Is pregnant or breast-feeding