Inclusion Criteria:

        A patient must meet all of the following criteria to be eligible for enrollment (defined as
        receiving the first trial treatment) in the trial:

          -  Histologically or cytologically confirmed unresectable in-transit (stage IIIc) or
             metastatic (stage IV) melanoma.

          -  Must have at least 1 lesion that qualifies as a measurable (target) lesion per RECIST
             v1.1

          -  Must have available and be willing to submit archival tissue as described in Section
             11.9. The tumor tissue must be adequate for PD-L1 testing.

          -  Subjects must be willing to have blood draws for future biomarker testing as outlined
             in Section 11.9.

          -  The subject has an ECOG performance score of ≤2 However; the phase 1b part will
             include only ECOG performance of 0-1 and life expectancy of >12 weeks

          -  Aged 18 years and older.

          -  The subject should not have received any treatment for advanced melanoma, EXCEPT, BRAF
             and/or MEK inhibitor (2 week washout).

          -  The subjects who have received adjuvant therapy including anti- PD-1 can be included
             in the study, if the last dose of the adjuvant treatment was ≥ 6 months prior to
             developing metastatic relapse.

          -  The subject is capable of understanding and complying with the protocol requirements
             and has signed the informed consent document.

          -  Female patients of childbearing potential, must have a negative urine or serum
             pregnancy test within 72 hours prior to taking the first dose of study medication. If
             the urine test is positive or cannot be confirmed as negative then a serum test is
             required which must be negative for the patient to enroll.

          -  Able to swallow pills

          -  The subject must have recovered to baseline or < Grade 1 CTCAE v 4 from toxicities
             related to any prior treatments, unless AE(s) are clinically nonsignificant and /or
             stable on supportive therapy.

        Exclusion Criteria:

        A patient meeting any of the following criteria is not eligible to participate in this
        study:

          -  Subject had prior treatment with any anti-PD-1, anti-PD-L1, or anti- PD-L2 agent for
             the treatment of advanced melanoma (although prior use in adjuvant setting is allowed
             if the last dose >6 months prior developing metastatic disease).

          -  Subjects with diagnosis of ocular and mucosal melanoma

          -  Subject had prior cabozantinib for any indication.

          -  Subject who received any small molecule tyrosine kinase inhibitor within 2 weeks
             before first dose of study treatment.

          -  Subject who has had chemotherapy, radioactive, or biological cancer therapy within
             four weeks prior to the first dose of study drug, or who has not recovered to CTCAE
             Grade 1 or better from the AEs due to cancer therapeutics administered more than four
             weeks earlier.

          -  Radiation therapy for bone metastasis within 2 weeks, any other radiation therapy
             within 4 weeks before first dose of study treatment. Systemic treatment with
             radionuclides within 6 weeks before the first dose of study treatment. Subjects with
             clinically relevant ongoing complications from prior radiation therapy are not
             eligible.

          -  Patient is currently participating or has participated in a study of an
             investigational agent or using an investigational device within 30 days of the first
             dose of study drug. (A patient in the Survival Follow up phase of an investigational
             agent where no further treatment is expected is eligible).Patient is expected to
             require any other form of systemic or localized antineoplastic therapy while on study.

          -  Patient is on any systemic corticosteroid therapy (more than 10 mg daily of prednisone
             or equivalent) within one week before the planned date for first dose of randomized
             treatment or on any other form of immunosuppressive medication.

          -  Patient has a history of a malignancy (other than the disease under treatment in the
             study) within 2 years prior to first study drug administration. This should exclude
             adequately treated Stage 1 or Stage 2 basal/squamous cell carcinoma of the skin,
             carcinoma in situ of the cervix or breast, or other in situ cancers. Shorter intervals
             can be considered after discussion with Sponsor.

          -  Patient has known active central nervous system (CNS) metastases and/or carcinomatous
             meningitis. Patients with previously treated brain metastases may participate provided
             they are stable (without evidence of progression by MRI for at least four weeks prior
             to the first dose of study drug), have no evidence of new or enlarging brain
             metastases, neurologically asymptomatic and are off systemic steroids for at least two
             weeks.

          -  Patient previously had a severe hypersensitivity reaction to treatment with another
             monoclonal antibody or small molecule tyrosine kinase inhibitor.

          -  Patient has an active autoimmune disease or a documented history of autoimmune disease
             or syndrome that requires systemic steroids or immunosuppressive agents. Patients with
             vitiligo or resolved childhood asthma/atopy would be an exception to this rule.
             Patients that require intermittent use of bronchodilators or local steroid injections
             would not be excluded from the study. Patients with hypothyroidism stable on hormone
             replacement will not be excluded from the study.

          -  Patient has an active infection requiring systemic therapy.

          -  Patient has a known history of Human Immunodeficiency Virus (HIV) (HIV 1/2
             antibodies).

          -  Patient has a known history of or is positive for Hepatitis B (HBsAg reactive) or
             Hepatitis C (HCV RNA [qualitative] is detected). Patients will be tested for hepatitis
             B or C infections during screening if they are considered by the investigator to be at
             higher risk for these infections and have not been previously tested.

          -  Patient has a history or current evidence of any condition, therapy, or laboratory
             abnormality that might confound the results of the study, interfere with the patient's
             participation for the full duration of the study, or is not in the best interest of
             the patient to participate, in the opinion of the treating Investigator.

          -  Patient has known psychiatric or substance abuse disorders that would interfere with
             cooperation with the requirements of the trial.

          -  Patient is, at the time of signing informed consent, a regular user (including
             "recreational use") of any illicit drugs or had a recent history (within the last
             year) of substance abuse (including alcohol).

          -  Patient is pregnant or breastfeeding, or expecting to conceive or father children
             within the projected duration of the study.

          -  Patient has received a live vaccine within 30 days prior to first dose.

          -  Patient requires concomitant anticoagulation with oral anticoagulants (eg, warfarin,
             direct thrombin and Factor Xa inhibitors) or platelet inhibitors (eg, clopidogrel).

          -  Allowed anticoagulants are the following:

               1. Low-dose aspirin for cardioprotection (per local applicable guidelines) is
                  permitted.

               2. Low-dose low molecular weight heparins (LMWH) are permitted.

               3. Anticoagulation with therapeutic doses of LMWH is allowed in subjects without
                  known brain metastases who are on a stable dose of LMWH for at least 6 weeks
                  before first dose of study treatment, and who have had no clinically significant
                  hemorrhagic complications from the anticoagulation regimen or the tumor

          -  Patient has experienced any of the following within 3 months before the first dose of
             study treatment:

               1. clinically-significant hematemesis, hematuria or gastrointestinal bleeding

               2. Clinically-significant hemoptysis of ≥ 0.5 teaspoon (2.5ml) of red blood

               3. any other signs indicative of pulmonary hemorrhage

          -  Present use or anticipated need for strong CYP3A4 inducers or inhibitors. Patients may
             not have received a strong CYP3A4 inducer within 12 days prior to registration nor a
             strong CYP3A4 inhibitor within 7 days prior to registration. Because the lists of
             these agents are constantly changing, it is important to regularly consult a
             comprehensive list such as the one located at
             http://medicine.iupui.edu/clinpharm/ddis/.

          -  The subject has uncontrolled, significant intercurrent or recent illness including,
             but not limited to, the following conditions:

               1. Cardiovascular disorders including,

                    -  Congestive heart failure (CHF): New York Heart Association (NYHA) Class 3
                       (moderate) or Class 4 (severe) at the time of screening.

                    -  Concurrent uncontrolled hypertension defined as sustained BP ≥150 mm Hg
                       systolic (grade 2), or ≥ 90 mm Hg diastolic (grade 2) despite optimal
                       antihypertensive treatment. (Note: If there is any BP measurement that is
                       performed within the screening period that is < 150 mm Hg systolic and < 90
                       mm Hg diastolic, then BP does not meet definition of sustained.)

                    -  Any congenital history of long QT syndrome.

                    -  Any of the following within 6 months before the first dose of study
                       treatment:

                    -  unstable angina pectoris

                         -  clinically-significant cardiac arrhythmias

                         -  stroke (including TIA, or other ischemic event)

                         -  myocardial infarction

                         -  thromboembolic event requiring therapeutic anticoagulation (Note:
                            subjects with a venous filter (e.g. vena cava filter) are not eligible
                            for this study

                    -  Cavitating pulmonary lesions(s) or known endotracheal or endobronchial
                       disease manifestation.

                    -  Lesions invading or encasing any major blood vessels.

               2. Gastrointestinal disorders particularly those associated with a high risk of
                  perforation or fistula formation including:

                    -  Any of the following within 28 days before the first dose of study
                       treatment:

                         -  intra-abdominal tumor/metastases invading GI mucosa (malignant
                            abdominal ascites does not constitute mucosal invasion)

                         -  active peptic ulcer disease,

                         -  inflammatory bowel disease (including ulcerative colitis and Crohn's
                            disease), diverticulitis, cholecystitis, symptomatic cholangitis or
                            appendicitis

                         -  malabsorption syndrome]

                    -  Any of the following within 6 months before the first dose of study
                       treatment:

                         -  history of abdominal fistula

                         -  gastrointestinal perforation

                         -  bowel obstruction or gastric outlet obstruction

                         -  intra-abdominal abscess. Note: Complete resolution of an
                            intra-abdominal abscess must be confirmed prior to initiating treatment
                            with cabozantinib even if the abscess occurred more than 6 months ago.

                    -  GI surgery (particularly when associated with delayed or incomplete healing)
                       within 28 days. Note: Complete healing following abdominal surgery must be
                       confirmed prior to initiating treatment with cabozantinib even if surgery
                       occurred more than 28 days ago.

               3. Other disorders associated with a high risk of fistula formation including PEG
                  tube placement within 3 months before the first dose of study therapy or
                  concurrent evidence of intraluminal tumor involving the trachea and esophagus.

               4. Moderate or severe hepatic impairment.

               5. Other clinically significant disorders such as:

                    -  active infection requiring systemic treatment within 28 days before the
                       first dose of study treatment

                    -  serious non-healing wound/ulcer/bone fracture within 28 days before the
                       first dose of study treatment

                    -  history of organ transplant

                    -  concurrent uncompensated hypothyroidism or thyroid dysfunction within 7 days
                       before the first dose of study treatment

                    -  Major surgery (eg, thoracotomy, removal or biopsy of brain metastasis)
                       within 3 months before Week 1 Day 1. Complete wound healing from major
                       surgery must have occurred 1 month before Week 1 Day 1 and from minor
                       surgery (eg, simple excision, tooth extraction) at least 10 days before Week
                       1 Day 1. Subjects with clinically relevant ongoing complications from prior
                       surgery are not eligible.

          -  The subject has organ and marrow function and laboratory values as follows:

        Table 2: Laboratory values for exclusion:

        System Laboratory Value

        Hematological Absolute neutrophil count (ANC) <1,500/mm3/mcL

        White blood cell count < 2,500/mm3.

        Platelets <100,000/mm3 / mcL

        Hemoglobin <9 g/dL- transfusion of packed red blood cells allowed up to 7 days prior to D1.

        Renal Serum creatinine >1.5 X upper limit of normal (ULN), GFR <30 ml/min

        Serum electrolytes Serum phosphorus, magnesium, and potassium < LLN supplementation allowed
        if necessary

        Hepatic Serum total bilirubin > 1.5 X ULN Patients with a total bilirubin > 1.5 X ULN will
        not be excluded if Direct bilirubin >/= ULN

        AST (SGOT) and ALT (SGPT) > 2.5 X ULN

        Albumin < 2.8 g/dl

        Coagulation International Normalized Ratio (INR) or Prothrombin Time (PT) Activated Partial
        Thromboplastin Time (aPTT) >1.3 ULN. Patients on oral anticoagulation are excluded

        Urine Urine protein/creatinine ratio (UPCR) > 1 (113.2 mg/mmol) creatinine or 24-hr urine
        protein of >/= 1 g

        * Cardiovascular: The subject has a corrected QT interval calculated by the Fridericia
        formula (QTcF) >/= 500ms within 14 days before Cycle 1 Day 1. Ejection fraction on Echo or
        MUGA </= 50%. NYHA class >/= 3. Note: If a single ECG show a QTcF with an absolute value
        </= 500 ms, two additional ECGs at intervals of approximately 2 min must be performed
        within 30 min after the initial ECG, and the average of these three consecutive results for
        QTcF will be used to determine eligibility.