PRIMARY OBJECTIVE:
I. To evaluate the efficacy of duvelisib (induction followed by maintenance [intermittent
dosing]) in patients with relapsed or refractory chronic lymphocytic leukemia (CLL), as
measured by the progression free survival (PFS).
SECONDARY OBJECTIVES:
I. To evaluate safety of duvelisib induction and maintenance (by intermittent dosing) in
relapsed/refractory CLL.
II. To evaluate clinical benefits to duvelisib treatment.
EXPLORATORY OBJECTIVE:
I. To evaluate T-cell populations in patients with CLL treated with duvelisib.
OUTLINE:
INDUCTION: Patients receive duvelisib orally (PO) twice daily (BID) on days 1-28. Cycles
repeat every 28 days for 12 weeks in the absence of disease progression or unacceptable
toxicity.
MAINTENANCE: Patients receive duvelisib PO BID on days 1-2, 8-9, 15-16, and 22-23. Cycles
repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for up to 12
months.
Inclusion Criteria:
- Ability to understand and the willingness to sign a written informed consent document.
- Histologically or flow cytometry confirmed diagnosis of B-CLL/small lymphocytic
lymphoma (SLL) according to National Cancer Institute - Working Group (NCI-WG) 1996
guidelines. Patients who lack CD23 expression on their leukemia cells should be
examined for (and found NOT to have) either t(11;14) or cyclin D1 overexpression, to
rule out mantle cell lymphoma.
- Participants have undergone >= 1 prior chemotherapy-based or immunotherapy-based
regimen or targeted therapy (e.g., inhibitors of BTK [e.g., ibrutinib], or BCL2 [e.g.,
venetoclax]) administered for >= 2 cycles (>= 8 weeks for oral therapies), and have
had either documented disease progression or no response (i.e., stable disease [SD])
to the most recent treatment regimen.
- Note: Individuals intolerant to ibrutinib therapy and those who progress on
ibrutinib are eligible as long as they satisfy the above criteria.
- Patients with CLL/SLL must demonstrate active disease meeting at least 1 of the
International Workshop on Chronic Lymphocytic Leukemia (IWCLL) 2018 criteria for
requiring treatment:
- A minimum of any one of the following constitutional symptoms:
- Unintentional weight loss > 10% within the previous 6 months prior to
screening.
- Extreme fatigue (unable to work or perform usual activities).
- Fevers of greater than 100.5 degrees Fahrenheit (F) for >= 2 weeks without
evidence of infection.
- Night sweats without evidence of infection.
- Evidence of progressive marrow failure as manifested by the development of, or
worsening of anemia or thrombocytopenia.
- Massive (i.e., > 6 cm below the left costal margin), progressive or symptomatic
splenomegaly.
- Massive nodes or clusters (i.e., > 10 cm in longest diameter) or progressive
lymphadenopathy.
- Progressive lymphocytosis with an increase of > 50% over a 2-month period, or an
anticipated doubling time of less than 6 months.
- Autoimmune anemia or thrombocytopenia that is poorly responsive to
corticosteroids.
- Symptomatic or functional extranodal involvement (eg, skin, kidney, lung, spine)
- Patients must have Eastern Cooperative Oncology Group (ECOG) performance status =< 2.
- Direct bilirubin =< 2 x institutional upper limit of normal (ULN); unless due to known
Gilbert's syndrome or compensated hemolysis directly attributable to CLL (prior to
starting study drug).
- Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) less than 2.5 x
institutional ULN (prior to starting study drug).
- Estimated creatinine clearance (CrCL) using the Cockcroft-Gault equation (or an
alternative equation, per institutional standard) >= 30 mL/min (prior to starting
study drug).
- Platelets >= 30,000/mm^3 independent of transfusion support, with no active bleeding,
and absolute neutrophil count (ANC) >= 500/mm^3, unless due to disease involvement in
the bone marrow (prior to starting study drug).
- Participant must be able to swallow tablets or capsules. A participant with any
gastrointestinal disease that would impair ability to swallow, retain, or absorb drug
is not eligible.
- Female participants of childbearing potential (defined as a sexually mature woman who
has not undergone surgical sterilization or who has not been naturally postmenopausal
for at least 12 consecutive months for women > 55 years of age) must have a negative
urine or serum pregnancy test within 72 hours prior to receiving the first dose of
study medication. If the urine test is positive or cannot be confirmed as negative, a
serum pregnancy test will be required.
- Female participants of childbearing potential must agree to use adequate methods of
contraception starting with the first dose of study therapy through 60 days after the
last dose of study therapy.
- Participants of childbearing potential are those who have not been surgically
sterilized or have not been free from menses for > 1 year without an alternative
medical cause.
- Male participants must agree to use an adequate method of contraception starting with
the first dose of study therapy through 60 days after the last dose of study therapy.
Exclusion Criteria:
- Prior therapeutic intervention with any of the following:
- Therapeutic anticancer antibodies within 4 weeks;
- Radio- or toxin-immunoconjugates within 10 weeks;
- Inhibitors of Bruton tyrosine kinase (BTK) (e.g., ibrutinib), BH3-mimetic
venetoclax, lenalidomide and other "targeted" therapy - within 6 half-lives
(i.e., 36 hours for ibrutinib)
- All other chemotherapy, radiation therapy within 3 weeks prior to initiation of
therapy.
- PI3K inhibitors (idelalisib, copanlisib or any investigational PI3K inhibitor
including duvelisib and umbralisib) at any time.
- Any adverse event related to prior therapy that has not recovered to grade =< 1.
- Chronic use of corticosteroids in excess of prednisone 30 mg/day or its equivalent.
- Allogeneic stem cell transplant within the past 12 months, or ongoing
immunosuppressive therapy other than prednisone =< 10 mg/day (or equivalent).
- Use of strong CYP3A4 inhibitors or inducers, in the one week prior to initiating study
treatment or concomitant.
- Unable to receive prophylactic treatment for pneumocystis, herpes simplex virus (HSV),
or herpes zoster (varicella zoster virus [VZV]) at screening.
- History of prior malignancy except:
- Malignancy treated with curative intent and no known active disease present for
>= 2 years prior to initiation of therapy on current study;
- Adequately treated non-melanoma skin cancer or lentigo maligna (melanoma in situ)
without evidence of disease;
- Adequately treated in situ carcinomas (e.g., breast, cervical, esophageal, etc.)
without evidence of disease;
- Asymptomatic prostate cancer managed with "watch and wait" strategy
- Uncontrolled immune hemolysis or thrombocytopenia (positive direct antiglobulin test
in absence of hemolysis or history of immune-mediated cytopenias are not exclusions).
- History of human immunodeficiency virus (HIV) infection or active hepatitis B or C.
- History of chronic liver disease.
- Major surgery (requiring general anesthesia) within 2 weeks prior to initiation of
therapy.
- Patients with clinically significant medical condition of malabsorption, inflammatory
bowel disease, chronic conditions which manifest with diarrhea, refractory nausea,
vomiting or any other condition that will interfere significantly with drug
absorption.
- History of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia
requiring medication or a pacemaker within the last 6 months prior to screening.
- Baseline QT interval corrected with Fridericia's method (QTcF) > 500 ms. (NOTE:
criterion does not apply to subjects with a right or left bundle branch block BBB).
- Active uncontrolled infection.
- Psychiatric illness/social situations that would limit compliance with study
requirements.
- Participant is pregnant or breastfeeding, or expecting to conceive or father children
within the projected duration of the trial, starting with the screening visit through
120 days after the last dose of trial treatment.
