Inclusion Criteria:

          1. Must have a pathologically documented solid tumor(s) that has relapsed from, or is
             refractory to standard treatment, or for which no standard treatment is available.

          2. Must have at least one measurable lesion as defined by RECISTv1.1 criteria for solid
             tumors.

          3. Must have received biological chemotherapy, immunotherapy or radiotherapy ≥4 weeks
             prior to starting the study treatment. Must have received small molecule chemotherapy
             ≥2 weeks or five half-lives (whichever is longer) prior to starting the study
             treatment.

          4. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.

          5. Life expectancy ≥3 months (as judged by the Investigator).

          6. Must have adequate hematologic, hepatic and renal function.

        Exclusion Criteria:

          1. Have undergone or plan to have major surgery or experienced severe trauma ≤28 days
             prior to starting the study treatment.

          2. Known hypersensitivity to IP ingredients or their analogues.

          3. Prior therapy with a MEK-inhibitor

          4. Receipt of any other investigational agent therapy within 4 weeks prior to starting
             study treatment.

          5. Any concurrent therapy for cancer treatment.

          6. Have active central nervous system lesion.

          7. Receiving and unable to discontinue medication which are strong inducers, strong
             inhibitors or enzyme substrates of cytochrome P450 CYP2C9 and CYP2C19 from 14 days
             prior to treatment.

          8. Grade 3 bleeding symptoms (NCI-CTCAE v5.0) within 4 weeks prior to starting study
             treatment.

          9. Unable to swallow IP or has refractory nausea and vomiting, malabsorption, external
             biliary diversion, or any significant small bowel resection that may interfere with
             adequate absorption of IP.

         10. ECG QTcB≥480msec in screening, or history of congenital long QT syndrome.

         11. Left ventricular ejection fraction (LVEF) <50%.

         12. History major cerebrovascular diseases within 6 months prior to enrollment.

         13. Infectious diseases requiring systemic treatment.

         14. History or current evidence of retinal diseases.

         15. Have active/chronic infection with hepatitis C, or positive hepatitis B surface
             antigen (HBsAg), or active/chronic infection with human immunodeficiency virus (HIV).

         16. Known active tuberculosis.

         17. History of allogeneic bone marrow transplantation or organ transplantation.

         18. Interstitial lung disease or interstitial pneumonitis, including clinically
             significant radiation pneumonitis.

         19. Pregnant or breast-feeding females.

         20. Previous or history of second malignancy within 5 years prior to study treatment

         21. Other conditions which may increase the risk associated with study participation, or
             interfere with the evaluation of study results.