Inclusion Criteria:

          1. Histologically and/or cytologically confirmed solid tumor from the following list,
             that is metastatic/advanced, for which no curative therapy exists:

               1. pancreatic adenocarcinoma

               2. high-grade serous ovarian cancer

               3. cervical squamous cell carcinoma

               4. prostate cancer

               5. ER+/HER2- or Triple Negative breast cancer

               6. driver mutation-positive NSCLC adenocarcinoma

               7. mesothelioma

               8. renal cell carcinoma

               9. bladder/ urothelial cancer

              10. head and neck carcinoma

              11. melanoma

              12. hepatocellular carcinoma

              13. endometrial cancer

          2. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1

          3. a. All patients must provide signed informed consent prior to any study specific
             procedures that are not part of standard medical care.

             b. Patients in the MTD expansion cohort will also provide their consent to undergo 2
             tumor biopsies: one prior to treatment (during screening) and the second on cycle 1
             day 4. All efforts should be made to obtain 2 fresh biopsies for each patient. A prior
             formalin-fixed, paraffin-embedded tissue block or unstained slides from primary or
             metastatic tumor, taken not earlier than the time of diagnosis of metastatic disease,
             may be used as a substitute for the 1st fresh biopsy in patients with no prior
             immune-oncology (IO) therapy. Patients enrolled in the MTD expansion cohort after
             prior exposure to a checkpoint inhibitor should have a baseline biopsy obtained after
             completion of the last prior checkpoint inhibitor therapy.

          4. Presence of clinically and/or radiologically documented disease. All radiology studies
             must be performed within 28 days prior to subject enrolment (subject enrolment=Day 1)

               1. Dose escalation part: patients do not need to have measurable disease by RECIST
                  1.1

               2. MTD expansion part: patients must have measurable disease by RECIST 1.1 and at
                  least one additional accessible lesion for biopsy. Previously irradiated lesions
                  may be considered measurable if there has been demonstrated progression in these
                  lesions.

          5. Previous therapy:

               1. Cytotoxic chemotherapy: There is no limit to the number of prior regimens
                  received.

               2. Other Systemic Therapy:

             i.All patients must have received at least 1 standard systemic cancer therapy for
             their tumor type and progressed following their most recent regimen ii.Treatment-naïve
             patients will be eligible only if they refused standard treatment.

             iii.Patients with prior anti-PD-1, anti PD-L1 or anti CTLA4 therapy are eligible if
             they have received such therapy for a minimum of 6 months and if they have documented
             progression of their disease on or off such therapy.

          6. Previously treated brain metastases must be asymptomatic without MRI evidence of
             progression for at least 8 weeks and off steroids for at least 4 weeks before study
             drug administration to be eligible.

          7. At least 21 days since the last chemotherapy, immunotherapy, biological (except for
             erythropoietin, denosumab and bisphosphonates), and at least 2 weeks from approved
             tyrosine kinase inhibitor therapy and recovery to grade 1 or less (except for
             alopecia) from any toxicity associated with such treatment.

          8. Systemic prednisone therapy ≤10 mg/day or equivalent is acceptable. Higher doses are
             not acceptable within 1 week prior to start of study treatment and as long as patient
             is treated with Nap. There is no limit on topical, intranasal or inhaled
             corticosteroids.

          9. Prior major surgery completed at least 4 weeks before study drug administration.

         10. Adequate hematologic and organ function: WBC (White Blood Cells) ≥3000/µL; neutrophils
             ≥1500/µL; platelets ≥100,000/µL; hemoglobin ≥10.0 g/dL (may have been transfused);
             creatinine ≤2 mg/dL; measured creatinine clearance >40 mL/min or calculated creatinine
             clearance (CL) > 40, as determined by Cockcroft-Gault (using actual body weight); AST
             (aspartate transaminase) ≤2.5 X ULN (Upper Limit of Normal); ALT ( alanine
             aminotransferase) ≤2.5 X ULN; bilirubin ≤ 1.5 mg/dL (unless diagnosed with Gilbert's
             syndrome); Coagulation International Normalized Ratio (INR) or Prothrombin Time (PT)
             and Activated Partial Thromboplastin Time (aPTT) ≤1.5 X ULN unless subject is
             receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of
             intended use of anticoagulants.

         11. Patients must be willing and able to comply with scheduled visits, drug administration
             plan, hospitalization for treatment (if needed) and scheduled follow-up visits and
             examinations as outlined in the protocol, including procedures undertaken to perform
             fresh tumor biopsies as per protocol

         12. Must have a life expectancy of at least 12 weeks

        Exclusion Criteria:

          1. Body weight <30kg

          2. Patients with a history of other malignancies requiring concurrent anticancer therapy.

          3. Active or prior documented autoimmune or inflammatory disorders (including
             inflammatory bowel disease (e.g. colitis or Crohn's disease), or other serious
             gastrointestinal chronic conditions associated with diarrhea), systemic lupus
             erythematosus, or Wegener syndrome (granulomatosis with polyangiitis), rheumatoid
             arthritis, uveitis, etc., within the past 2 years prior to the start of treatment. The
             following are exceptions to this criterion:

               1. Patients with alopecia

               2. Patients with Graves' disease, vitiligo or psoriasis not requiring systemic
                  treatment (within the last 2 years).

               3. Patients with endocrinopathies (e.g. following Hashimoto syndrome) stable on
                  hormone replacement or do not require any therapy.

          4. History of primary immunodeficiency, history of allogenic organ transplant that
             requires therapeutic immunosuppression and the use of immunosuppressive agents within
             28 days of enrolment*.

             *NOTE: Intranasal/inhaled corticosteroids or systemic steroids that do not to exceed
             10 mg/day of prednisone or equivalent dose of an alternative corticosteroid are
             permissible

          5. Patients who have uncontrolled inter-current illness, including but not limited to,
             ongoing or active infection, symptomatic congestive heart failure, uncontrolled
             hypertension, unstable angina pectoris, uncontrolled cardiac arrhythmia, active
             interstitial lung disease, serious chronic gastrointestinal conditions associated with
             diarrhea, or psychiatric illness/social situations that would limit compliance with
             study requirement, substantially increase risk of incurring AEs (Adverse Events) or
             compromise the ability of the patient to give written informed consent.

          6. Recent history of live attenuated vaccine within 30 days prior to the first dose of
             study drug.

             Note: Patients, once enrolled, should not receive live vaccine whilst receiving study
             drug and up to 30 days after the last dose of study drug.

          7. Known current drug or alcohol abuse

          8. Known active or latent tuberculosis (TB) infection (purified protein derivative [PPD]
             test is not required) as indicated by any of the following: PPD recently converted to
             positive; chest x-ray with evidence of infections infiltrate.

          9. Hepatitis B (known positive HBV surface antigen (HBsAg) result), hepatitis C. Patients
             with a past or resolved HBV infection (defined as the presence of hepatitis B core
             antibody [anti-HBc] and absence of HBsAg) are eligible. Patients positive for
             hepatitis C (HCV) antibody are eligible only if polymerase chain reaction (PCR) is
             negative for HCV RNA.

         10. Evidence for human immunodeficiency virus (HIV) (positive HIV 1/2 antibodies(

         11. Underlying medical conditions that, in the Principal Investigator's opinion, will make
             the administration of study drug hazardous or obscure the interpretation of toxicity
             determination or adverse events

         12. Female patients who are pregnant or breastfeeding or male or female patients of
             reproductive potential who are not willing to employ effective birth control from
             screening to 90 days after the last dose of study treatment (either durvalumab
             monotherapy or durvalumab + Nap combination therapy).

             •Highly effective methods of contraception are defined as one that results in a low
             failure rate (e.g., less than 1% per year) when used consistently and correctly. Note
             that some contraception methods are not considered highly effective (e.g., male or
             female condom with or without spermicide; female cap, diaphragm, or sponge with or
             without spermicide; non-copper containing intrauterine device; progestogen-only oral
             hormonal contraceptive pills where inhibition of ovulation is not the primary mode of
             action [excluding Cerazette/desogestrel which is considered highly effective]; and
             triphasic combined oral contraceptive pills).

         13. Simultaneous participation in any other study involving investigational drugs or
             having participated in study less than 4 weeks prior to start of study treatment

         14. History of leptomeningeal carcinomatosis

         15. History of active primary immunodeficiency

         16. Any unresolved toxicity NCI CTCAE Grade ≥2 from previous anticancer therapy with the
             exception of alopecia, vitiligo, and the laboratory values defined in the inclusion
             criteria

         17. Patients with Grade ≥2 neuropathy will be evaluated on a case-by-case basis after
             consultation with the Medical Monitor.

         18. Patients with irreversible toxicity not reasonably expected to be exacerbated by
             treatment with durvalumab may be included only after consultation with the Medical
             Monitor.

         19. Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) ≥470 ms
             calculated from 3 ECGs (within 15 minutes at 5 minutes apart)

         20. Known allergy or hypersensitivity to any of the study drugs or any of the study drug
             excipients

         21. Major surgical procedure (as defined by the Investigator) within 28 days prior to the
             first dose of IP (Investigational Product). Note: Local surgery of isolated lesions
             for palliative intent is acceptable.

         22. Patients who have received prior anti-PD-1, anti PD-L1 or anti CTLA-4:

               -  Must not have experienced a toxicity that led to permanent discontinuation of
                  prior immunotherapy.

               -  All AEs while receiving prior immunotherapy must have completely resolved or
                  resolved to baseline prior to screening for this study.

               -  Must not have experienced a Grade ≥3 immune-related AE or an immune-related
                  neurologic or ocular AE of any grade while receiving prior immunotherapy. Note:
                  Patients with an endocrine AE of Grade ≤2 are permitted to enroll if they are
                  stably maintained on appropriate replacement therapy and are asymptomatic.

               -  Must not have required the use of additional immunosuppression other than
                  corticosteroids for the management of an AE, not have experienced recurrence of
                  an AE if re-challenged, and not currently require maintenance doses of >10 mg
                  prednisone or equivalent per day.

         23. Involvement in planning and/or conduct of the study (applies to both sponsor staff
             and/or staff at the study site).