Inclusion Criteria:

          -  Histological or cytological confirmation diagnosis of Non Small Cell Lung
             Cancer(NSCLC),Stage III-IV, no previous anticancer treatment, accept chemotherapy;

          -  18-75years old, male or female;

          -  Eastern Cooperative Oncology Group (ECOG) performance score 0-2;

          -  Life expectancy of at least 3 months;

          -  At least one radiographically measurable lesion per RECIST 1.1;

          -  Willing to join the clinic trail and sign informed consent, able to comply with
             scheduled visits and treatment schedule.

        Exclusion Criteria:

          -  Presence of cerebral metastases;

          -  Confirmed EGFR, ALK, ROS1 mutation or PD-L1-positive expression (TPS≥ 50%) in genetic
             test;

          -  Participants with pleural effusion who need thoracic drainage or pleural injection of
             chemotherapy drugs;

          -  Current or preparing treatment of target therapy;

          -  Current or preparing treatment of radiotherapy to the thorax;

          -  Current or preparing treatment of tumor immunotherapy;

          -  Current treatment of lipid-decreasing;

          -  Pregnant woman or suckling period woman; fertile patients who are unwilling or unable
             to take effective contraceptive measures during the research and 6 months after the
             end of the research;

          -  History of mental disorders；

          -  Severe and uncontrolled organic lesion or infection, including cardiopulmonary
             failure, renal failure，and other reasons, which lead to poor tolerance of
             chemotherapy;

          -  Participated in other clinical trials of small molecule research drugs within 28 days
             before enrollment or participated in other clinical trials of big molecule research
             drugs within 3 months before enrollment;

          -  Known allergy or intolerance against study medications;

          -  With unlisted exclusion criteria but are considered not suitable for the clinical
             study by researchers.