Inclusion Criteria:

          -  Be 18 years of age or older at the time of signing the informed consent.

          -  Have a histologically or cytologically confirmed diagnosis of a solid tumour
             malignancy that is advanced and/or metastatic or unresectable and for which standard
             or curative measures do not exist or are no longer effective.

          -  Have measurable disease as per the Response Evaluation Criteria in Solid Tumours
             (RECIST) 1.1 or as per a modified RECIST, if applicable.

          -  Have a performance status score of 0 or 1 according to the Eastern Cooperative
             Oncology Group (ECOG) scale.

          -  Be able to ingest oral medication.

          -  Have adequate organ function,

          -  Have recovered to ≤ grade 1 from the effects of any prior cancer therapy, except for
             alopecia; irreversible neuropathy should have recovered to ≤ grade 2. Toxic effects
             also include laboratory test abnormalities.

          -  Be afebrile at baseline prior to SLC-391 administration (ie, < 38.0 °C).

          -  Have a life expectancy greater than 3 months, in the Investigator's opinion.

          -  The following time must have elapsed between previous therapy for cancer and first
             dose of SLC-391:

               1. At least 4 weeks since previous cancer-directed therapy, including
                  investigational agents or devices (cytotoxic agents, targeted therapy including
                  monoclonal antibodies, immunotherapy, hormonal therapy, and prior radiotherapy)
                  with the exception of nitrosoureas/mitomycin where 6 weeks since these therapies.

               2. At least 4 weeks or 5 times the elimination half-life (whichever is shortest) of
                  any investigational agents, including drugs, biologics, or combination products.

               3. At least 4 weeks since any major surgery.

          -  Sexually active women of child-bearing potential and sexually active male subjects
             with a female partner of child-bearing potential or pregnant must agree to use
             acceptable methods of contraception to avoid pregnancy from screening, for the
             duration of the study, and for 3 months after the last dose of study drug. Male
             subjects must also agree to refrain from donating sperm for the duration of the study,
             including during dose interruptions and for 3 months after the last dose administered.

          -  Be able and willing to provide signed informed consent and comply with the
             requirements, assessment schedule, dosing schedule, and restrictions listed in the
             informed consent form (ICF) and study protocol.

        Exclusion Criteria:

          -  Prior use of any AXL inhibitor

          -  Localised or metastatic prostate cancer subjects who are concurrently receiving
             abiraterone or enzalutamide. Those subjects on stable (>3 months) anti-cancer hormonal
             therapy are allowed.

          -  Refractory nausea and vomiting, chronic gastrointestinal (GI) diseases, GI bleeding,
             ulceration, or perforation within 12 weeks prior to the first dose of the study drug,
             or significant bowel resection that would preclude adequate absorption, distribution,
             metabolism, or excretion of the study drug.

          -  History of myocardial infarction, unstable angina, congestive heart failure (New York
             Heart Association class ≥ III/IV), cerebrovascular accident, transient ischaemic
             attack, limb claudication at rest, stroke or subarachnoid hemorrhage, coagulopathy,
             deep vein thrombosis, pulmonary embolism in the 3 months prior to consent.

          -  Uncontrolled hypertension (≥ 160/100 mmHg).

          -  History of or ongoing symptomatic dysrhythmias, uncontrolled atrial or ventricular
             arrhythmias, or heart block (excluding 1st degree block, consisting of PR interval
             prolongation only). Controlled atrial fibrillation is allowed.

          -  QTcF interval > 480 msec.

          -  Severe respiratory illness that significantly impacts functional status in daily life
             including a known history of active tuberculosis (Mycobacterium tuberculosis).

          -  History of significant weight loss (≥ 7 kgs/15 lbs) within 4 weeks prior to the first
             dose of study drug.

          -  History of primary immunodeficiency or those with known human immunodeficiency virus
             (HIV), or known active hepatitis B (HBV; including core antibody and surface antigen;
             AntiHBc and HBsAg, respectively) or hepatitis C (HCV) infection. Note: No testing for
             HIV, Hepatitis B or C is required unless mandated by a local health authority.

          -  Active uncontrolled infection, or an unstable or severe intercurrent medical condition
             that requires treatment.

          -  History of solid organ transplant or bone marrow transplant.

          -  Any condition or illness that, in the opinion of the Investigator, would compromise
             subject safety or interfere with the evaluation of the safety of the study drug and
             jeopardises compliance with the protocol and study visits.

          -  Has known active central nervous system (CNS) metastases and/or carcinomatous
             meningitis. Note: Subjects with previously treated brain metastases may participate
             provided they are radiologically stable, i.e., without evidence of progression for at
             least 4 weeks by repeat imaging (note that the repeat imaging should be performed
             during study screening), clinically stable and without requirement of steroid
             treatment for at least 14 days prior to first dose of study treatment.

          -  History of prior malignancy, except for the following: curatively treated basal or
             squamous cell carcinoma of the skin (nonmelanoma skin cancer); cervical or vaginal
             intra-epithelial neoplasia; or noninvasive breast cancer in situ at screening.
             Subjects with other curatively treated malignancies who have had no evidence of
             metastatic disease and a > 2-year disease-free interval may be enrolled after approval
             by the Medical Monitor or SignalChem Lifesciences (SLC) designee.

          -  Females who are pregnant, planning to become pregnant, or breastfeeding.

          -  Hypersensitivity to the study drug or excipients (lactose, microcrystalline cellulose,
             magnesium stearate, and gelatin capsule shell).