Inclusion Criteria:

          -  Newly diagnosed histologically confirmed MGMT unmethylated glioblastoma multiforme
             (WHO grade IV). Patients with secondary glioblastoma, in particular those who are IDH1
             or IDH2 mutant, will not be excluded. High grade gliomas with molecular features of
             glioblastoma will be included. MGMT methylation status must be confirmed by standard a
             PCR-based assay.

          -  Patients who had prior craniotomy with biopsy, subtotal resection, total gross
             resection, or re-resection will be permitted.

          -  Consent to genome sequencing and dbGaP-based data sharing and has provided or will
             provide germline (PBMC) and tumor DNA/RNA samples of adequate quality for sequencing.
             (Acquisition of specimens for sequencing and the sequencing itself may be done as part
             of routine care or another research project.)

          -  At least 18 years of age.

          -  Karnofsky performance status ≥ 60%

          -  Normal bone marrow and organ function as defined below:

               -  Absolute neutrophil count ≥ 1,500/mcL

               -  Platelets ≥ 100,000/mcL

               -  Total bilirubin ≤ 1.5 x IULN

               -  AST(SGOT)/ALT(SGPT) ≤ 3.0 x IULN

               -  Creatinine ≤ IULN OR creatinine clearance ≥ 60 mL/min/1.73 m2 for patients with
                  creatinine levels above institutional normal

          -  Systemic corticosteroid therapy is permitted provided dosing is no greater than 4 mg
             per day (dexamethasone or equivalent) on the day of vaccine administration.

          -  Bevacizumab will be allowed if given for symptomatic control of vasogenic edema and to
             avoid high dose of corticosteroids.

          -  Women of childbearing potential and men must agree to use adequate contraception
             (hormonal or barrier method of birth control, abstinence) prior to study entry and for
             the duration of study participation, including at least 5 months (for women of
             childbearing potential) and at least 7 months (for men) after last dose of study drug.
             Should a woman become pregnant or suspect she is pregnant while participating in this
             study, she must inform her treating physician immediately.

          -  Ability to understand and willingness to sign an IRB approved written informed consent
             document (or that of legally authorized representative, if applicable).

        Exclusion Criteria:

          -  As this study aims to assess the immunogenicity of personalized neoantigen DNA vaccine
             plus plasmid encoded IL-12 as an adjuvant, no prior immunotherapy will be permitted.

          -  Inadequate tissue acquisition to allow for neoantigen screening.

          -  No candidate neoantigen identified during screening.

          -  A history of other malignancy ≤ 3 years previous with the exception of non-melanoma
             skin cancer, any in situ cancer that has been successfully resected and cured, treated
             superficial bladder cancer, or any early-stage solid tumor that was successfully
             resected without need for adjuvant radiation or chemotherapy.

          -  Receiving any other investigational agents within 4 weeks of beginning study
             treatment.

          -  Known allergy, or history of serious adverse reaction to, vaccines such as
             anaphylaxis, hives, or respiratory difficulty.

          -  A history of allergic reactions attributed to compounds of similar chemical or
             biologic composition to any agents used in the study.

          -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active
             infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
             arrhythmia, or psychiatric illness/social situations that would limit compliance with
             study requirements.

          -  History of immunodeficiency disorder or autoimmune condition requiring active
             immunosuppressive therapy. This includes inflammatory bowel disease, ulcerative
             colitis, Crohn's disease, systemic vasculitis, scleroderma, psoriasis, multiple
             sclerosis, hemolytic anemia, immune-mediated thrombocytopenia, rheumatoid arthritis,
             systemic lupus erythematosus, Sjögren's syndrome, sarcoidosis, or other rheumatologic
             disease or any other medical condition or use of medication which might make it
             difficult for the patient to complete the full course of treatments or to generate an
             immune response to vaccines.

          -  Presence of clinically significant increased intracranial pressure (e.g. impending
             herniation) or hemorrhage, uncontrolled seizures, or requirement for immediate
             palliative treatment.

          -  Pregnant and/or breastfeeding. Women of childbearing potential must have a negative
             pregnancy test within 7 days of first dose of vaccine.

          -  Presence of acute or chronic bleeding or clotting disorder that would contraindicate
             IM injections

          -  Fewer than 2 acceptable sites available for IM injection and CELLECTRA® 2000 EP
             considering the deltoid and anterolateral quadriceps muscles:

               -  Tattoos, keloids, or hypertrophic scars located within 2 cm of intended
                  administration site

               -  Implantable-cardioverter-defibrillator (ICD) or pacemaker (to prevent a
                  life-threatening arrhythmia) that is located ipsilateral to the deltoid injection
                  site (unless deemed acceptable by a cardiologist)

               -  Any metal implants or implantable medical device within the intended treatment
                  site (i.e. electroporation area).