Inclusion Criteria:

          -  advanced progressive MPNs, defined as intermediate and high risk MF or advanced PV
             resistant, failed or intolerant to JAK2 inhibitor therapy requiring medical therapy
             and patients with MDS/MPN Overlap and CMML having failed or for whom there are no
             standard therapies are available, are eligible. Patients will be allocated to one of
             two treatment arms:

               1. Pembrolizumab

               2. Pembrolizumab plus JAK2 inhibitor Ruxolitinib

          -  Patients with relapsed* or refractory* Hodgkin lymphoma (HL) who progress on PD-1
             inhibitory treatment after achieving a partial response (PR) or complete response (CR)
             or stable disease (SD) or who are non-responsive to PD-1 inhibitory therapy. Patients
             must have failed appropriate standard treatment options.

          -  Relapsed: disease progression after most recent therapy

          -  Refractory: failure to achieve CR or PR to most recent therapy

          -  -The following laboratory values obtained less than 7 days prior to registration.

               -  Total bilirubin ≤ 1.5 x Upper Limit normal (ULN) (except Gilbert's syndrome or
                  known hemolysis or leukemic infiltration)

               -  AST (SGOT) and ALT (SGPT) ≤ 2.5 x ULN or < 5 x ULN if organ involvement

               -  Alkaline Phosphatase < 5 x ULN

               -  Serum creatinine ≤ 2 x ULN or 24 hour Cr clearance >60ml/min

               -  Hematological inclusion criteria for:

               -  MPN: -Platelet count ≥50,000/μL; Absolute neutrophil count (ANC) ≥250/μL

          -  Hematological inclusion criteria for:

               -  MPN: -Platelet count ≥50,000/μL ;Absolute neutrophil count (ANC) ≥250/μL

               -  MDS/MPN Overlap, CMML: Platelet count ≥25,000/μL; Absolute neutrophil count (ANC)
                  ≥250/μ

               -  HL-Platelet count ≥75,000/μL; Absolute neutrophil count (ANC) ≥1000/μL (800/ μL
                  if marrow disease involvement; ECOG Performance Status (PS) 0 or 1 (Appendix I)

          -  Female subject of childbearing potential should have a negative urine or serum
             pregnancy within 72 hours prior to receiving the first dose of study medication. If
             the urine test is positive or cannot be confirmed as negative, a serum pregnancy test
             will be required.

          -  Subjects of childbearing potential are those who have not been surgically sterilized
             or have not been free from menses for > 1 year.

          -  Male subjects should agree to use an adequate method of contraception starting with
             the first dose of study therapy through 120 days after the last dose of study therapy.

        Exclusion Criteria:

          -  Uncontrolled intercurrent illness including, but not limited to active uncontrolled
             infection, or psychiatric illness/social situations that would limit compliance with
             study requirements.

          -  Any of the following prior therapies:

               -  Cytotoxic Chemotherapy less than 14 days prior to registration

               -  Immunotherapy less than 14 days prior to registration

               -  Biologic therapy (i.e. antibody therapies) less than 28 days prior to
                  registration (see also 3.32)

               -  Radiation therapy less than 14 days prior to registration

               -  Targeted therapies (i.e. kinase inhibitors, less than 7 days or 5 half-life's
                  whichever is shorter)

               -  Hydroxyurea (HU) is allowed for blast count control throughout study

               -  Receiving any other investigational agent which would be considered as a
                  treatment for the primary neoplasm ≤ 14 days prior to registration

          -  Active uncontrolled CNS leukemia. NOTE: Positive (cyto)pathology is allowed and
             patient can receive intrathecal chemotherapy

          -  Immunocompromised patients and patients known to be HIV positive and currently
             receiving antiretroviral therapy.

          -  Hypersensitivity to Ruxolitinib or any of its excipients.

          -  Acute Myeloid Leukemia with > 30% blasts in the bone marrow of peripheral blood

          -  Major surgery ≤ 28 days prior to treatment

          -  Clinically significant heart disease

          -  Diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other
             form of immunosuppressive therapy within 7 days prior to the first dose of trial
             treatment.

          -  Has had a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study
             Day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events
             due to agents administered more than 4 weeks earlier.

          -  Has had prior chemotherapy, targeted small molecule therapy, or radiation therapy
             within 2 weeks prior to study Day 1 or who has not recovered (i.e., ≤ Grade 1 or at
             baseline) from adverse events due to a previously administered agent.

          -  Has a known additional malignancy that is progressing or requires active treatment.

          -  Has active autoimmune disease that has required systemic treatment in the past 2

          -  Has known psychiatric or substance abuse disorders that would interfere with
             cooperation with the requirements of the trial.

        Pregnant women

          -  Nursing women

          -  Men or women of childbearing potential who are unwilling to employ adequate
             contraception

          -  Patients who have undergone an allogeneic stem cell transplantation within 5 years
             from registration are excluded