Inclusion Criteria:
- 1.≥ 18 and ≤ 75 years of age
- 2.Eastern Cooperative Oncology Group(ECOG)performance scale 0 - 1.
- 3.Life expectancy of more than 3 weeks
- 4.Histologically confirmed，locally advanced and/or metastatic non-squamous NSCLC of
stage IIIB (unsuitable for radiotherapy) or IV or recurrent NSCLC with measurable
lesion/ according to RECIST 1.1 which has not received radiotherapy or cryotherapy.
- 5.Documented evidence of tumor harboring an activating EGFR mutation (exon19 del and
L858R)
- 6.None previous chemotherapy or targeted therapy. NOTE: neoadjuvant and/or adjuvant
therapy is allowed which is completed before 6 months
- 7.Prior radiation therapy is allowed if: 25% or less of total bone marrow had been
irradiated,pelvis and chest had not been irradiated; at least 4 weeks have elapsed
from the completion of radiation treatment, and the acute toxicity from radiation
treatment had been recover; irradiated lesion is not including measurable lesions
unless documented progress after radiation.
- 8.Adequate hepatic, renal, heart, and hematologic functions (Absolute Neutrophil
Count(ANC) ≥ 1.5×109/L, Platelet (PLT) ≥ 100×109/L, Hemoglobin(HB) ≥ 100 g/L, total
bilirubin within 1.5×the upper limit of normal(ULN), and serum transaminase≤2.5×the
Upper Limit Of Normal(ULN), serum creatine ≤ 1 x Upper Limit Of Normal(ULN),
creatinine clearance rate ≥ 50ml/min
- 9.For women of child-bearing age, the pregnancy test results (serum or urine) within 7
days before enrolment must be negative. They will take appropriate methods for
contraception during the study until the 8th week post the last administration of
study drug. For men (previous surgical sterilization accepted), will take appropriate
methods for contraception during the study until the 8th week post the last
administration of study drug.
- 10.Signed and dated informed consent. Willingness and ability to comply with scheduled
visits, treatment plans, laboratory tests, and other study procedure.
Exclusion Criteria:
- 1.small cell lung cancer (including small cell and non-small cell mixed lung cancer)
- 2.Symptomatic brain metastases (Patients who have no symptoms and is not needed to
receive therapy before 21 days may participate in this trial, but need to be confirmed
by MRI\CT or venography that no hematencephalon symptom)
- 3.Radiologically documented evidence of tumor lesions from large vessels ≤ 5mm or
major blood vessel invasion or encasement by cancer; Obvious cavity or necrosis formed
in the tumor.
- 4. hypertensive patients are in the combination therapy of two or more
antihypertensive drugs.
- 5.patients with positive T790M mutation by Gene detection.
- 6.Patients who suffered from grade II or above myocardial ischemia or myocardial
infarction, uncontrolled arrhythmias (including QT interval male ≥ 450 ms, female ≥
470 ms). Grade III-IV cardiac insufficiency according to New York Heart
Association(NYHA) criteria or echocardiography check: left ventricular ejection
fraction (LVEF)<50%;
- 7.History of pulmonary interstitial diseases or concurrent pulmonary interstitial
diseases.
- 8.Coagulation disfunction（INR>1.5 or PT>Upper Limit Of Normal(ULN)+4s or Activated
Partial Thromboplastin Time (APTT) >1.5 Upper Limit Of Normal(ULN)）, hemorrhagic
tendency or receiving the therapy of thrombolysis or anticoagulation
- 9.Daily hemoptysis up to two teaspoons or more before enrollment
- 10.History of clinically relevant major bleeding event=<3 months (e.g.
gastrointestinal hemorrhage, Hemorrhagic acne， bleeding gastric ulcer, occult blood
test ≥ (++), and vasculitis ;
- 11.Within 12 months before the first treatment occurs artery / venous thromboembolic
events, such as cerebral vascular accident (including transient ischemic attack(TIA),
hematencephalon, cerebral infarction), deep vein thrombosis and pulmonary embolism,
etc.
- 12.Known inherited and acquired hemorrhagic and thromboplastic possibility (such as
hemophilia, coagulopathy, thrombocytopenia, hypersplenism, etc.)
- 13.Long-term untreated wounds or fractures（in addition to tumor-induced pathological
fractures）
- 14.Within 4 weeks of major surgery and/or injures, fractures , ulceration
- 15.Significant factors that influence the ingestion and absorption of medicine, (e.g.
unable swallow, chronic diarrhea and intestinal obstruction);
- 16.History of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess ≤ 6 months.
- 17.Urine protein≥++, and 24h urine protein quantitation≥1.0g;
- 18.Symptomatic serous effusion requiring treatment .(including hydrothorax, ascites,
hydropericardium);
- 19.Active infection need antimicrobial treatments（such as antibiotics and antiviral
drugs should be used, excluding anti-hepatitis B treatment and antifungal therapy. ）
- 20.History of psychiatric drugs abuse and not be abstinent, or dysphrenia
- 21.Less than 4 weeks from the last clinical trial
- 22.History or concomitant other malignancy except cured basal cell skin cancer, or
carcinoma in situ of the cervix, or superficial bladder cancer;
- 23.Administration of strong/potent cytochrome P450 (CYP)3A4 inhibitors within 7 days,
or inducers within 12 days;
- 24.Pregnant or breastfeeding women；patients who have fertility are unwilling or unable
to take effective contraceptive measures;
- 25.Other conditions regimented at investigators' discretion
