Key Inclusion Criteria:

          1. For NHL patients: Age ≥18 years. For B cell ALL patients: age ≥18 years to ≤70 years

          2. Refractory or relapsed non-Hodgkin lymphoma, as evidenced by 2 or more lines of prior
             therapy, or histologically confirmed B cell ALL, refractory or relapsed.

          3. Eastern Cooperative Oncology Group performance status 0 or 1.

          4. Adequate renal, liver, cardiac and pulmonary organ function

          5. Female subjects of childbearing potential and male subjects must agree to use
             acceptable method(s) of contraception from enrollment through at least 12 months after
             CTX110 infusion.

          6. Agree to participate in an additional long-term follow-up study after completion of
             this study.

        Key Exclusion Criteria:

          1. Treatment with any gene therapy or genetically modified cell therapy, including CAR T
             cells.

          2. For NHL patients: prior allogeneic HSCT. For B cell ALL patients: prior allogeneic
             HSCT within 6 months, and/or any evidence of GvHD.

          3. History of central nervous system (CNS) involvement by malignancy

          4. History of a seizure disorder, cerebrovascular ischemia/hemorrhage, dementia,
             cerebellar disease, or any autoimmune disease with CNS involvement.

          5. Presence of bacterial, viral, or fungal infection that is uncontrolled or requires IV
             anti-infectives.

          6. Active HIV, hepatitis B virus or hepatitis C virus infection.

          7. Previous or concurrent malignancy, except basal cell or squamous cell skin carcinoma,
             adequately resected and in situ carcinoma of cervix, or a previous malignancy that was
             completely resected and has been in remission for ≥5 years.

          8. For NHL patients: Use of systemic anti-tumor therapy or investigational agent within
             14 days or 5 half-lives, whichever is longer, of enrollment. For B cell ALL patients:
             Use of systemic antitumor therapy within 7 days of enrollment.

          9. Primary immunodeficiency disorder or active autoimmune disease requiring steroids
             and/or other immunosuppressive therapy.

         10. Women who are pregnant or breastfeeding.