1. Male/female participants who are at least 20 years of age on the day of signing
2. Previously untreated and histologically proven NSCLC harboring PD-L1 expression (≥1%
in a biopsy specimen), as measured by immunohistochemistry (22C3).
3. Resectable clinical stage IB-IIIA NSCLC carefully evaluated by experienced thoracic
surgeons. (If N2 disease is suspected, the histological or cytological confirmation is
mandatory) (UICC version 8)
4. Pulmonary resection more than lobectomy and lymph node dissection is considered to be
possible for complete resection of the tumor.Be able to undergo protocol therapy,
including necessary surgery.
5. Has adequate pulmonary function for pulmonary resection. Predicted postoperative
FEV1.0 is 800 mL or more. ｛(predicted postoperative FEV1.0) = (preoperative FEV1.0) x
(18-number of resected segment) / 18｝
6. ECOG performance status of 0 to 1.
7. Has measurable disease as defined by RECIST 1.1 as determined by investigator.
8. Has adequate organ function as defined in the following criteria. Clinical test data
must meet the following criteria within 14 days of the registration. The registration
day is the standard, including the same day of the week two weeks prior.
a Neutrophil count: ≥ 1500/mm3 b Hemoglobin (Hb) ≥ 9.0 g/dL c Platelet count: ≥ 10.0 ×
104/mm3 d AST (SGOT) ≤ 100 IU/L e ALT (SGPT): ≤ 100 IU/L f Total bilirubin: ≤ 1.5
mg/dL (Total bilirubin: ≤ 3.0 mg/dL for patient with Gilbert's syndrome) g Creatinine:
CRE ≤ 1.5 mg/dL, or creatinine clearance of 40 mL/minute or higher [Even when the
value is less than 40 mL/min in the Cockcroft-Gault equation, if the measured value
from a 24-hour urine collection is 40 mL/min or higher, the patient qualifies.] *
Cockcroft-Gault equation: Male: Ccr=｛(140－age) × body weight (kg)｝/｛72 × serum CRE
value (mg/dL）｝Female: Ccr=0.85 × ｛(140－age) × body weight (kg)｝/｛72 × serum CRE value
(mg/dL) h SpO(2) ≥ 92% (room air) i International normalized ratio (INR) ≤ 1.5 j
PTT(aPTT) ≤ 1.5 × ULN k Urinary protein ≤1+ (if it is ≥2+, store the urine for 24
hours, and if the urinary protein is <1,000 mg, the patient is qualified).
9. Female who are likely to become pregnant are negative with pregnancy tests (urine or
serum) within 7 days prior to enrollment. They agree to conduct proper contraception
(total abstinence, intrauterine contraceptive device, hormone release system, or
contraceptive implant and oral contraceptive) for both men and women during the trial
and from the final investigational dosing up to 120 days
10. The participant (or legally acceptable representative if applicable) is willing and
able to provide written informed consent/assent for the trial.
1. Has one of the following tumor locations/types:
- NSCLC involving the superior sulcus
- Large cell neuro-endocrine cancer (LCNEC)
- Sarcomatoid tumor
- Synchronous lung cancer (within 5 years), current non-pure GGN on TSCT, or pure
GGN with 15mm or more on TSCT
2. Has an active infection requiring systemic therapy.
3. Has an active autoimmune disease that has required systemic treatment in past 2 years
(ie, with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (eg, thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency) is not considered a form
of systemic treatment and is allowed.
4. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy (dose
exceeding 10mg daily of prednisone equivalent) or any other form of immunosuppressive
therapy within 7 days prior the first dose of trial drug.
5. Has a known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.
6. Hypersensitivity or allergy to pembrolizumab, ramucirumab, or any of their excipients.
7. Has a known history of, or any evidence of active, interstitial lung disease.
8. Has a hypertension that is difficult to control (systolic blood pressure ≥160 mmHg and
diastolic blood pressure ≥90 mmHg) despite treatment with several hypotensive agents.
9. Has an acute coronary syndrome (including myocardial infarction and unstable angina),
and with a history of coronary angioplasty or stent placement performed within 6
months before enrollment
10. Has a history of New York Heart Association congestive heart failure of grade II or
above, unstable angina, myocardial infarction within the past 6 months, or serious
cardiac arrhythmia associated with significant cardiovascular impairment within the
past 6 months
11. Has a severe (hospitalization required) complications (intestinal palsy, intestinal
obstruction, pulmonary fibrosis, diabetes difficult to control, heart failure,
myocardial infarction, unstable angina, renal failure, liver failure, liver cirrhosis,
mental disease, cerebrovascular disease etc).
12. Has a known history of human immunodeficiency virus (HIV) infection. No HIV resting is
required unless mandated by local health authority.
13. Has a known history of active TB (Bacillus Tuberculosis)
14. Negative for HBs antigens, HBs antibodies, and HBc antibodies. However, if positive
for HBs and/or HBc antibodies, the patient can be registered as long as they are
negative for HBV-DNA.
15. Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the trial, interfere with the subject's
participation for the full duration of the trial, or is not in the best interest of
the subject to participate, in the opinion of the treating investigator.
16. Has a known additional malignancy that is progressing or requires active treatment
within the past (5 years) or received anti-cancer drug including hormone therapy.
Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of
the skin, bladder carcinoma, or carcinoma in situ (eg, in situ cervical cancer, breast
carcinoma, CIS and AIS of the lung) that have undergone potentially curative therapy
are not excluded.
17. Has received a live vaccine within 30 days prior to the first dose of trial drug.
Examples of live vaccines include, but are not limited to, the following: measles,
mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus
Calmette-Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection
are generally killed virus vaccines and are allowed; however, intranasal influenza
vaccines (eg, FluMist) are live attenuated vaccines and are not allowed.
18. Is pregnant or breastfeeding or expecting to conceive or father children within the
projected duration of the trial, starting with the pre-screening or screening visit
through 120 days (or longer as specified by local institutional guidelines) after the
last dose of trial treatment.
19. Has history of hemoptysis (more than 1/2 cups in teaspoon) in 2 months before
registration, or invasion of major vessels by cancer or major vessel narrowing is
recognized on the image.
20. Image shows cavity formation in the tumor.
21. Is considered highly likely to have complications related to bleeding.
* Obvious tumor invasion to the chest great vessel, cavity formation of the lung
lesion, or the existence of obvious thrombus on the image are recognized, etc.
22. Has past history of gastrointestinal perforation, peptic ulcer, diverticulosis or
fistula within 6 months.
※ As for peptic ulcer, registration is permitted when disease condition is controlled
by appropriate treatment.
23. Has a history of pulmonary embolism / deep vein thrombosis, or other thromboembolism
within 3 months before registration.
24. Received major surgery within 28 days before registration, or received procedures for
placement of subcutaneous venous access devices within seven days before registration.
25. Severe wounds, ulcers or fractures within 28 days before registration.
26. Has undergone long-term treatment using aspirin, nonsteroidal anti-inflammatory drugs
(such as ibuprofen, naproxen), dipyridamole, clopidogrel or similar drugs. However,
use of aspirin up to 325 mg / day once a day is acceptable.
27. Patients who are receiving anticoagulant therapy and whose dose of oral anticoagulant
or low molecular weight heparin is not stable. In case of taking warfarin,
registration is permitted if there is no active bleeding or no risk of bleeding with
PT-INR being 3 or less.
28. Is currently participating and receiving study therapy or has participated in a study
of an investigational agent and received study therapy or used an investigational
device within 4 weeks of registration.
Note: Participants who have entered the follow-up phase of an investigational trial
may participate as long as it has been 4 weeks after the last dose of the previous
29. Has no intention to comply with the study protocol or it is impossible to comply.
30. Investigator or clinical trial doctor judged unsuitable as subject of this trial.