Inclusion criteria:

          -  Capable of giving signed informed consent which includes compliance with the
             requirements and restrictions listed in the informed consent form (ICF) and in the
             protocol.

          -  Participant must be above 18 years of age or country's legal age of majority if the
             legal age is >18 years old, at the time of signing the informed consent.

          -  Participant has been previously diagnosed with multiple myeloma (MM) based on standard
             criteria and currently requires treatment because MM has relapsed following a
             response, according to International Myeloma Working Group (IMWG) criteria.

          -  Participant has received at least two previous therapies including lenalidomide and a
             proteasome inhibitor and has demonstrated disease progression on last therapy or after
             completion of the last therapy.

          -  Participants with measurable disease defined as at least one of the following:

          -  Serum M protein ≥ 0.5 g/dL (≥5 g/L).

          -  Urine M protein ≥ 200 mg/24 hours.

          -  Serum free light chain (FLC) assay: Involved FLC assay ≥ 10 mg/dL (≥ 100 mg/L) and an
             abnormal serum FLC ratio (<0.26 or >1.65).

          -  Male or female: Contraceptive use by men or women.

        Exclusion criteria:

          -  Malignancy within 3 years prior to enrollment.

          -  Eastern Cooperative Oncology Group (ECOG) performance status score >2.

          -  Inadequate hematological, liver or renal function.

          -  Serum calcium (corrected for albumin) level above the upper limit of normal (ULN)
             range.

          -  Patients with prior anti-CD38 treatment are excluded if:

               -  Refractory to anti-CD38 treatment defined as progression on or within 60 days of
                  the last dose of the anti-CD38 or,

               -  Intolerant to the anti-CD38 previously received or,

               -  Progression after initial response on anti-CD38 therapy with a washout period
                  inferior to 9 months before the first dose of isatuximab SC or IV.

          -  Participant did not achieve a minimal response or better to at least one of the
             previous lines of treatment (ie, primary refractory disease is not eligible).

          -  Received any investigational drug within 14 days or 5 half-lives of the
             investigational drug, whichever is longer.

          -  Prior anti-cancer therapy within 14 days.

          -  Any >Grade 1 adverse reaction unresolved from previous treatments according to the
             NCI-CTCAE v5.0. The presence of alopecia or peripheral neuropathy ≤ Grade 2 without
             pain is allowed.

          -  Previous allogeneic stem cell transplantation with active Graft Versus Host Disease or
             being under immunosuppressive therapy in the last 2 months previously to the inclusion
             in the trial.

          -  Daily requirement for corticosteroids.

          -  Known to be HIV+ or to have hepatitis A or uncontrolled or active hepatitis B virus
             (HBV) infection (patients with positive HBsAg [HBsAg] and/or HBV DNA) or active HCV
             (HCV) infection (positive HCV RNA and negative anti-HCV).

          -  Active tuberculosis and severe infections requiring treatment with antibiotic
             parenteral administration.

          -  Any clinically significant, uncontrolled medical conditions that, in the
             Investigator's opinion, would expose excessive risk to the patient or may interfere
             with compliance or interpretation of the study results.

          -  History of erythema multiforme or severe hypersensitivity to prior immunomodulatory
             drugs (IMiDs).

          -  Hypersensitivity or history of intolerance to immunomodulatory drugs (IMiDs),
             dexamethasone, mannitol, pregelatinized starch, sodium stearyl fumarate, histidine (as
             base and hydrochloride salt), arginine hydrochloride, poloxamer 188, sucrose or any of
             the other components of study therapy that are not amenable to premedication with
             steroids and histamine H2 blockers or would prohibit further treatment with these
             agents.

          -  Inability to tolerate thromboprophylaxis.

        The above information is not intended to contain all considerations relevant to a patient's
        potential participation in a clinical trial.