Inclusion Criteria:

          -  Patients must have a new histologically confirmed diagnosis of endometrioid
             adenocarcinoma of the endometrium who are candidates for hysterectomy.

               -  Note: Patients with recurrent disease are not eligible.

          -  Patients must be willing to provide archival tumor biopsy slides from the specimen
             (e.g. endometrial biopsy or dilation and curettage) which diagnosed them with
             endometrial cancer.

               -  (Please note: Given the amount of tissue obtained from these specimens is often
                  much more than a core needle biopsy, we do not anticipate difficulties with
                  insufficient tissue.)

          -  Patients should be treatment naive. They should not have received any endometrial
             cancer directed therapy including medroxyprogesterone acetate, aromatase inhibitors,
             other hormonal treatments or radiation therapy for treatment of endometrial cancer.

               -  Note: Patients can have used oral contraceptives or hormonal replacement therapy
                  provided these were discontinued 28 days prior to trial enrollment.

          -  Eastern Cooperative Oncology Group (ECOG) performance status =< 2 within 28 days prior
             to registration for protocol therapy.

          -  Patients must have adequate organ function for all of the following criteria within 28
             days of registration.

          -  Absolute neutrophil count (ANC) >= 1.5 x 10^9 /L (within 28 days of registration).

          -  Platelets >= 100 x 10^9 /L (within 28 days of registration).

          -  Hemoglobin >= 8 g/dL (within 28 days of registration).

               -  Patients may receive erythrocyte transfusions to achieve this hemoglobin level at
                  the discretion of the investigator. Initial treatment must not begin earlier than
                  the day after the erythrocyte transfusion.

          -  Total bilirubin =< 1.5 x upper limit of normal (ULN) (within 28 days of registration).

               -  Patients with Gilbert?s syndrome with a total bilirubin =< 2.0 times ULN and
                  direct bilirubin within normal limits are permitted.

          -  Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN (within
             28 days of registration).

          -  Serum creatinine =< 1.5 x ULN (within 28 days of registration).

          -  Patients with a history of surgical sterilization are eligible for this study. OR

          -  Patients must have post-menopausal status due to menopause (surgical or natural).
             Patients must meet at least one of the following criteria:

               -  Bilateral oophorectomy

               -  Age >= 55 years

               -  Age =< 55 years and amenorrhea (absence of menstruation) for > 12 months OR

          -  Patients who are not post-menopausal or previously sterilized.

               -  i.e. a female of childbearing potential (patients who are not post-menopausal),
                  must have a negative serum pregnancy test within 7 days of the first dose of
                  study treatment (abemaciclib and/or letrozole). Patient must agree to use
                  adequate birth control (condoms with spermicidal agent or abstinence) while on
                  the study and for 3 weeks after completion of treatment.

          -  Patients should be able to swallow oral medications.

          -  Patients must have the ability to understand and the willingness to sign a written
             informed consent prior to registration on study.

          -  Patients must be willing and able to have a window of >= 15 days prior to their
             scheduled hysterectomy surgery after registration.

        Exclusion Criteria:

          -  Patients who have had chemotherapy, hormonal therapy or radiotherapy directed at the
             treatment of endometrial cancer prior to entering the study or those who have not
             recovered from adverse events due to agents administered more than 4 weeks prior to
             registration are not eligible.

          -  Patients may not be receiving any other investigational agents. A wash out period of 4
             weeks before registration is required for eligibility.

          -  Patients who have a history of allergic reactions attributed to compounds of similar
             chemical or biologic composition to abemaciclib or letrozole or any of its excipients
             are not eligible.

          -  Patients receiving CYP3A inducers or strong CYP3A inhibitors will not be eligible for
             this study. A wash-out period of minimum 5 half-lives or 7 days, whichever is shorter,
             before registration is required for the patient to become eligible.

          -  Patients who have a known personal history of any of the following conditions: syncope
             of cardiovascular etiology, ventricular arrhythmia of pathological origin (including,
             but not limited to, ventricular tachycardia and ventricular fibrillation), or sudden
             cardiac arrest are not eligible.

          -  Patients who have known active bacterial infection (requiring intravenous [IV]
             antibiotics at time of initiating study treatment), fungal infection, or detectable
             viral infection (such as known human immunodeficiency virus [HIV] positivity or with
             known active hepatitis B or C (for example, hepatitis B surface antigen positive).
             Screening is not required for enrollment.

               -  Note: patients with uncomplicated urinary tract infection or uncomplicated
                  cystitis are eligible.

          -  Patients who have an uncontrolled intercurrent illness including, but not limited to
             any of the following, are not eligible:

               -  Hypertension that is not controlled on medication

               -  Baseline grade 2 or higher diarrhea.

               -  Ongoing or active infection requiring systemic treatment.

               -  Symptomatic congestive heart failure.

               -  Unstable angina pectoris.

               -  Psychiatric illness that would limit compliance with study requirements.

               -  Social situations that would limit compliance with study requirements.

               -  Serious preexisting medical condition(s) that would preclude participation in
                  this study (for example, interstitial lung disease, severe dyspnea at rest or
                  requiring oxygen therapy, history of major surgical resection involving the
                  stomach or small bowel, or preexisting Crohn?s disease or ulcerative colitis or a
                  preexisting chronic condition resulting in baseline grade 2 or higher diarrhea).

               -  Any other illness or condition that the treating investigator feels would
                  interfere with study compliance or would compromise the patient?s safety or study
                  endpoints.

          -  Female patients who are pregnant or nursing are not eligible.

          -  Patients who are unable to retain oral medication, and patients who have
             gastrointestinal disorders or abnormalities that would interfere with absorption of
             the study drugs are not eligible.