Inclusion Criteria:

        Diagnosis:

          -  Progressive disease with histologically proven initial diagnosis of glioblastoma,
             medulloblastoma, or ependymoma; With confirmation of progression by either MRI or CSF
             analysis; Measureable disease is not required for study entry; Patients with
             progressive disease must have been previously treated with therapeutic radiation as
             part of treatment for the initial brain cancer diagnosis or for a prior relapse.

          -  Newly diagnosed DIPG (diffuse intrinsic pontine glioma) with no prior therapy
             (including no prior radiation); Biopsy is not required for DIPG.

          -  Central review of tissue diagnosis is required, except non-biopsied DIPG; Archival
             tumor tissue must be located and available prior to study entry.

          -  Patients with metastatic disease are eligible.

        Lansky or Karnofsky performance status score must be ≥ 50%.

        Adequate renal function: creatinine ≤ 1.5-times upper limit of age-adjusted normal.

        Adequate liver function:

          -  ALT ≤ 5-times upper limit of normal.

          -  Total bilirubin ≤ 1.5-times upper limit of normal.

        Adequate Bone marrow function:

          -  Absolute neutrophil count (ANC) ≥ 750/mcL.

          -  Platelets ≥ 75,000/mcL (transfusion independent).

          -  Hemoglobin ≥ 8 g/dL (transfusion independent).

        Central nervous system: seizure disorders must be well controlled on antiepileptic
        medication.

        Prior therapy

          -  DIPG patients must not have been treated with any prior radiation or medical therapy.

          -  Patients previously treated with indoximod are excluded.

          -  Patients previously treated with any other immunotherapy agent, including other
             IDO-targeted drugs, are eligible for enrollment.

          -  Patients previously treated with chemotherapy drugs included in this protocol are
             eligible for enrollment.

        Patients must be 14 days from the administration of any investigational agent or prior
        cytotoxic therapy with the following exceptions:

          -  Temozolomide dosed at or above 150 mg/m2 (allowed, but must be at least 21 days from
             the last dose of temozolomide).

          -  Must be 28 days from administration of antibody-based therapies (e.g., bevacizumab),
             tumor-directed vaccines, or cellular immune therapies (e.g., T cells, NK cells, etc).

          -  Must be 56 days from administration of tumor-directed therapies using infectious
             agents (e.g., viruses, bacteria, etc).

        Pregnant women are excluded from this study, where pregnancy is confirmed by a positive
        urine or serum hCG laboratory test.

        Patients must be able to swallow pills.

        .

        Exclusion Criteria:

        Patients who cannot swallow indoximod pills are excluded.

        Patients previously treated with indoximod are excluded.

        Patients with DIPG who have been treated with any prior radiation or medical therapy are
        excluded.

        Midline glioma that does not include significant brain stem involvement is not considered
        DIPG for enrollment purposes, and is excluded.

        Patients with active systemic infection requiring treatment, including any HIV infection or
        toxoplasmosis, are excluded.

        Patients with active autoimmune disease that requires systemic therapy are excluded.

        Pregnant women are excluded