Inclusion Criteria:

          1. Patients ≥ 18 years

          2. Confirmed diagnosis of WM (according to consensus panel / WHO criteria) with
             measurable IgM paraprotein

          3. Previously untreated disease at any stage requiring therapy at the discretion of the
             treating physician. Suggested criteria for initiating treatment include:

               -  haematological suppression to Hb <10g/dl, or neutrophils <1.5x109/l or platelets
                  <150x109/l

               -  clinical evidence of hyperviscosity

               -  bulky lymphadenopathy and/or bulky splenomegaly

               -  presence of B symptoms

          4. No previous chemotherapy (prior plasma exchange and steroids are permissible)

          5. Eastern Cooperative Oncology Group (ECOG) performance status grade 0 - 2

          6. Life expectancy of greater than 6 months

          7. Written informed consent

          8. Willing to comply with the contraceptive requirements of the trial

          9. Negative serum or urine pregnancy test for women of childbearing potential (WOCBP)

        Exclusion Criteria:

          1. Prior therapy for WM

          2. Lymphoplasmacytic lymphoma with no detectable serum IgM paraprotein

          3. CNS involvement with WM

          4. Autoimmune cytopenias

          5. Major surgery within 4 weeks prior to randomisation

          6. Clinically significant cardiac disease including the following:

               -  Myocardial infarction within 6 months prior to randomisation

               -  Unstable angina within 3 months prior to randomisation

               -  New York Heart Association class III or IV congestive heart failure

               -  History of clinically significant arrhythmias (e.g. sustained ventricular
                  tachycardia, ventricular fibrillation, torsades de pointes)

               -  QTcF > 480 msecs based on Fredericia's formula or Bazette's formula

               -  History of Mobitz II second degree or third degree heart block without a
                  permanent pacemaker in place

               -  Uncontrolled hypertension as indicated by a minimum of 2 consecutive blood
                  pressure measurements showing systolic blood pressure > 170 mmHg and diastolic
                  blood pressure > 105 mm Hg

               -  Cardiac event within 6 months of screening (e.g. coronary artery stent) requiring
                  dual antiplatelet treatment

          7. History of stroke or intracranial haemorrhage within 6 months prior to randomisation

          8. Requires anticoagulation with warfarin or equivalent vitamin K antagonists (direct
             oral anticoagulants (DOACs) allowed)

          9. History of severe bleeding disorders considered not to be disease related (Haemophilia
             A, B or von Willebrand's disease)

         10. Requires ongoing treatment with a strong CYP3A inhibitor or inducer

         11. Known infection with HIV, or serologic status reflecting active hepatitis B or C
             infection as follows:

               -  Presence of hepatitis B surface antigen (HBsAg). In addition, if negative for
                  HBsAg but HBcAb positive (regardless of HBsAb status), a HB DNA test will be
                  performed and if positive the patient will be excluded

               -  Presence of hepatitis C virus (HCV) antibody. Patients with presence of HCV
                  antibody are eligible if HCV RNA is undetectable

         12. Women who are pregnant or breastfeeding or males expecting to conceive or father
             children at any point from the start of treatment until the end of the "at risk
             period"

         13. Renal failure (creatinine clearance <30 ml/min as estimated by the Cockroft-Gault
             equation)

         14. Patients with chronic liver disease with hepatic impairment Child-Pugh class B or C

         15. Known history of anaphylaxis following exposure to rat or mouse derived CDR-grafted
             humanised monoclonal antibodies.

         16. Inability to swallow oral medication

         17. Disease significantly affecting gastrointestinal function and/or inhibiting small
             intestine absorption (e.g. malabsorption syndrome, resection of the small bowel,
             poorly controlled inflammatory bowel disease)

         18. Active systemic infection requiring treatment

         19. Concomitant treatment with another investigational agent

         20. Any life-threatening illness, medical condition, organ system dysfunction, need for
             profound anticoagulation, or bleeding disorder, which, in the investigator's opinion,
             could compromise the patient's safety, or put the study at risk

         21. Unwilling or unable to take PCP prophylaxis (e.g. cotrimoxazole)

         22. History of prior malignancy, with the exception of the following:

               -  Malignancy treated with curative intent and with no evidence of active disease
                  present for more than 3 years prior to screening and felt to be at low risk for
                  recurrence by treating physician

               -  Adequately treated non-melanomatous skin cancer or lentigo maligna melanoma,
                  superficial bladder cancer, carcinoma in situ of the cervix or breast or
                  localized Gleason score 6 prostate cancer without current evidence of disease.