Inclusion Criteria:

          -  Participants must be ≥18 years of age inclusive, at the time of signing the informed
             consent.

          -  Participants with following histologically or cytologically confirmed advanced solid
             tumors that have progressed after treatment with all available therapies for
             metastatic disease that are known to confer clinical benefit, or are intolerant to
             treatment, or refuse standard treatment. Note: there is no limit to the number of
             prior treatment regimens. Immune checkpoint inhibitors are also allowed in
             pretreatment.

               -  Dose Escalation: all solid tumor types

               -  Tumor type-specific high-dose (MTD or MAD) Expansion cohorts: Will be grouped by
                  tumor type, but no specific biomarker selection will be applied:

                    -  NSCLC

                    -  HNSCC

                    -  Colorectal cancer MSS

                    -  Urothelial cancer

               -  Tumor type-specific low-dose Expansion cohort: Any tumor type based on data from
                  dose escalation and expansion indicating pharmacodynamics effect and/or clinical
                  response from the tumor type-specific high-dose(MTD or MAD) expansion.

          -  Have measurable disease per RECIST 1.1 as assessed by CT/MRI. At least one measurable
             lesion by RECIST 1.1 is required. Lesions situated in a previously irradiated area, or
             in an area subjected to other loco-regional therapy, are considered measurable if
             progression has been demonstrated in such lesions.

               -  Life expectancy at least 12 weeks.

               -  Eastern Cooperative Oncology Group (ECOG)performance status of 0 to 1.

          -  Adequate bone marrow and organ function as assessed by the following laboratory tests
             performed within 7 days before treatment initiation.

               -  Bone marrow reserve:

                    -  Absolute neutrophil count (ANC) ≥ 1.5 x 109/L

                    -  Hemoglobin (Hb) ≥ 9.0g/dL, without erythropoietin dependency and without
                       packed red blood cell (pRBC) transfusion within last 2 weeks.

                    -  Platelet count ≥ 100 x 109/L. Transfusion to meet the inclusion criteria
                       will not be allowed.

               -  Hepatic:

                    -  Total bilirubin ≤ 1.5 x the upper limit of normal range (ULN). Known Gilbert
                       syndrome is allowed if total bilirubin is ≤ 3 x ULN.

                    -  Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 x
                       ULN (≤ 5 x ULN for participants with liver metastases).

                    -  Albumin > 25 g/L.

               -  Renal:

                  --- eGFR ≥ 60 mL/min as calculated using the MDRD equation or creatinine level ≤
                  1.5x ULN.

               -  Lipase and amylase ≤ 1.5 x ULN.

               -  Coagulation:

                    -  International normalized ratio (INR) OR prothrombin time (PT) AND activated
                       partial thromboplastin time (aPTT) ≤ 1.5 x ULN unless the participant is
                       receiving anticoagulant therapy as long as PT or aPTT is within therapeutic
                       range of intended use of anticoagulants.

          -  Adequate cardiac function, measured by echocardiography within 28 days before start of
             study intervention (left ventricular ejection fraction within institutional normal
             range for age and gender).

        Exclusion Criteria:

          -  Severe (CTCAE v.5 Grade ≥ 3) infections within 4 weeks before the first BAY2416964
             administration, including but not limited to hospitalization for complications of
             infection, bacteremia, or severe pneumonia. Clinically active infections (CTCAE v.5 >
             Grade 1) within 2 weeks before the first BAY2416964 administration.

          -  Active autoimmune disease that has required systemic treatment in past 2 years (i.e.,
             with use of disease modifying agents, corticosteroids or immunosuppressive drugs).
             Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid
             replacement therapy for adrenal or pituitary insufficiency) is not considered a form
             of systemic treatment and is allowed.

          -  Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
             (in dosing exceeding 10 mg daily of prednisone or equivalent) or any other form of
             immunosuppressive therapy within 7 days prior the first dose of study intervention.

          -  Congestive heart failure New York Heart Association (NYHA) greater than Class I or
             cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers or
             calcium channel blockers.

          -  Has known active central nervous system (CNS) metastases and/or carcinomatous
             meningitis.

        Participants with previously treated brain metastases may participate provided they are
        radiologically stable, i.e., without evidence of progression for at least 4 weeks by repeat
        imaging (note that repeat imaging should be performed during study screening), clinically
        stable and without requirement of steroid treatment for at least 14 days prior to first
        dose of study intervention.

          -  Interstitial lung disease or chronic obstructive pulmonary disease (COPD) with ongoing
             signs and symptoms at the time of screening. Has a history of (non-infectious)
             pneumonitis that required steroids or has current pneumonitis.

          -  Significant acute gastrointestinal disorders with diarrhea as a major symptom, e.g.
             Crohn's disease, malabsorption, or ≥ NCI-CTCAE v. 5.0 Grade 2 diarrhea of any
             etiology.

          -  History of organ allograft transplantation, including allogeneic bone marrow
             transplantation.

          -  Has received prior radiotherapy within 2 weeks before start of BAY2416964 or received
             radiation therapy to the lung that is > 30 Gy within 6 months before start of study
             intervention. Participants must have recovered from all radiation-related toxicities,
             not require corticosteroids, and not have had radiation pneumonitis. A 1-week washout
             is permitted for palliative radiation (≤2 weeks of radiotherapy) to non-CNS disease.

          -  Treatment with systemic immunosuppressant medications (including but not limited to
             doses > 10 mg/day prednisone or equivalent, cyclophosphamide, azathioprine,
             methotrexate, thalidomide, and anti-tumor necrosis factor [anti-TNF] agents) within 2
             weeks before the first BAY2416964 administration.

        The use of inhaled corticosteroids, or low doses of glucocorticoids (no more than 10 mg/day
        prednisone or equivalent; if a higher dose would be needed to maintain adrenal function
        investigator must obtain approval from sponsor), and mineralocorticoids (e.g.
        fludrocortisone for adrenal insufficiency) is allowed.