Inclusion Criteria:

          1. Ability to understand and the willingness to sign a written informed consent document.

          2. Age ≥ 18 years

          3. Histologically or cytologically confirmed urothelial carcinoma of the bladder.
             Non-urothelial histologies and upper tract disease are excluded.

          4. Has clinical stage T2-T4b, N0-3, M0 urothelial carcinoma

          5. DECIPHER-Non-basal (Group A) OR DECIPHER-Basal but cisplatin-ineligible (Group B)

             a. Cisplatin-ineligible based on ≥1 of the following:

             i. CrCl <60 ml/min

             ii. Grade 2 hearing loss or peripheral neuropathy

             iii. ECOG performance status of 2

          6. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2

          7. Life expectancy of at least 12 weeks

          8. Body weight >30kg

          9. Adequate normal organ and marrow function as defined below:

               1. Hemoglobin ≥ 8.0 g/dL and asymptomatic

               2. Absolute neutrophil count (ANC ≥1.5 x 109/L)

               3. Platelet count ≥100 x 109/L

               4. Serum bilirubin ≤ 1.5 x Institutional Upper Limit of Normal (ULN) (Note: This
                  will not apply to patients with confirmed Gilbert's syndrome (persistent or
                  recurrent hyperbilirubinemia that is predominantly unconjugated in the absence of
                  hemolysis or hepatic pathology), who will be allowed only in consultation with
                  their physician.)

               5. AST/SGOT and ALT/SGPT ≤ 2.5 x ULN

               6. Measured creatinine clearance (CL) >30 mL/min

         10. Evidence of post-menopausal status or negative serum pregnancy test for female
             pre-menopausal patients. Women will be considered post-menopausal if they meet the
             requirements below.

               1. Women < 45 years of age would be considered post-menopausal if they underwent
                  surgical sterilization (bilateral oophorectomy or hysterectomy.

               2. Women 45 to <50 years of age would be considered post-menopausal if they have
                  been amenorrheic for 18 months or more following cessation of exogenous hormonal
                  treatments, if they have a documented follicle-stimulating hormone levels in the
                  post-menopausal range (> 40 mlU/mL) or underwent surgical sterilization
                  (bilateral oophorectomy or hysterectomy).

               3. Women ≥50 years of age would be considered post-menopausal if they have been
                  amenorrheic for 12 months or more following cessation of all exogenous hormonal
                  treatments, had radiation-induced menopause with last menses >1 year ago, had
                  chemotherapy-induced menopause with last menses >1 year ago, if they have a
                  documented follicle-stimulating hormone levels in the post-menopausal range (> 40
                  mlU/mL) or underwent surgical sterilization (bilateral oophorecomy, bilateral
                  salpingectomy or hysterectomy).

         11. Patient is willing and able to comply with the protocol for the duration of the study
             including undergoing treatment and scheduled visits and examinations including follow
             up.

        Exclusion Criteria:

        Subjects must not have any of the following:

          1. Prior systemic chemotherapy for bladder cancer

          2. Any prior treatment with CTLA-4, including tremelimumab PD-1 or PD-L1 including
             durvalumab checkpoint inhibitors

          3. Administration of an investigational therapeutic within 28 days prior to Cycle 1, Day
             1

          4. Receipt of the last dose of anticancer therapy (chemotherapy, immunotherapy, endocrine
             therapy, targeted therapy, biologic therapy, tumour embolization, monoclonal
             antibodies) ≤28 days prior to the first dose of study drug.

          5. Prior pelvic radiation that precludes bladder radiation

          6. Concurrent enrolment in another clinical study, unless it is an observational
             (non-interventional) clinical study or during the follow-up period of an
             interventional study

          7. Prior cystectomy

          8. Any unresolved toxicity NCI CTCAE Grade ≥2 from previous anticancer therapy with the
             exception of alopecia, vitiligo, and the laboratory values defined in the inclusion
             criteria

               1. Patients with Grade ≥2 neuropathy will be evaluated on a case-by-case basis after
                  consultation with the Duke Principal Investigator.

               2. Patients with irreversible toxicity not reasonably expected to be exacerbated by
                  treatment with durvalumab or tremelimumab may be included only after consultation
                  with the Duke Principal Investigator.

          9. Any concurrent chemotherapy, investigational product, biologic, or hormonal therapy
             for cancer treatment. Concurrent use of hormonal therapy for non-cancer-related
             conditions (e.g., hormone replacement therapy) is acceptable.

         10. Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of
             radiation within 4 weeks of the first dose of study drug

         11. Major surgical procedure (as defined by the Investigator) within 28 days prior to the
             first dose of IP. Note: Local surgery of isolated lesions for palliative intent is
             acceptable.

         12. Current or prior use of immunosuppressive medication within 14 days before the first
             dose of durvalumab or tremelimumab. The following are exceptions to this criterion:

               1. Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra
                  articular injection)

               2. Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of
                  prednisone or its equivalent

               3. Steroids as premedication for hypersensitivity reactions (e.g., CT scan
                  premedication)

         13. Active or prior documented autoimmune or inflammatory disorders (including
             inflammatory bowel disease [e.g., colitis or Crohn's disease], diverticulitis [with
             the exception of diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome,
             or Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid
             arthritis, hypophysitis, uveitis, etc]). The following are exceptions to this
             criterion:

               1. Patients with vitiligo or alopecia

               2. Patients with hypothyroidism (e.g., following Hashimoto syndrome) stable on
                  hormone replacement

               3. Any chronic skin condition that does not require systemic therapy

               4. Patients without active disease in the last 5 years may be included but only
                  after consultation with the study physician

               5. Patients with celiac disease controlled by diet alone

         14. Uncontrolled intercurrent illness, including but not limited to, ongoing or active
             infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable
             angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic
             gastrointestinal conditions associated with diarrhea, or psychiatric illness/social
             situations that would limit compliance with study requirement, substantially increase
             risk of incurring AEs or compromise the ability of the patient to give written
             informed consent

         15. History of another primary malignancy except for:

               1. Malignancy treated with curative intent and with no known active disease ≥5 years
                  before the first dose of IP and of low potential risk for recurrence

               2. Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
                  of disease

               3. Adequately treated carcinoma in situ without evidence of disease

         16. History of allogenic stem cell transplant

         17. History of active primary immunodeficiency

         18. Active infection including, clinical evidence of active tuberculosis (cough >2 weeks'
             duration, fevers, night sweats, weight loss, and/or abnormal lung imaging), hepatitis
             B (known positive HBV surface antigen (HBsAg) result), hepatitis C, or human
             immunodeficiency virus (positive HIV 1/2 antibodies). Patients with a past or resolved
             HBV infection (defined as the presence of hepatitis B core antibody [anti-HBc] and
             absence of HBsAg) are eligible. Patients positive for hepatitis C (HCV) antibody are
             eligible only if polymerase chain reaction is negative for HCV RNA.

         19. Receipt of live attenuated vaccine within 30 days prior to Cycle 1 Day 1. Note:
             Patients, if enrolled, should not receive live vaccine whilst receiving durvalumab or
             tremelimumab and up to 30 days after the last dose of durvalumab or tremelimumab.

         20. Female patients who are pregnant or breastfeeding or male or female patients of
             reproductive potential who are not willing to employ effective birth control from
             screening to 90 days after the last dose of durvalumab monotherapy or 180 days after
             the last dose of durvalumab + tremelimumab combination therapy.

         21. Known allergy or hypersensitivity to any of the study drugs or any of the study drug
             excipients.

         22. Prior randomisation or treatment in a previous durvalumab and/or tremelimumab clinical
             study regardless of treatment arm assignment.

         23. Any condition which, in the opinion of the investigator, would preclude participation
             in this trial