Inclusion Criteria:

          -  Subjects are eligible to be included in the study only if all the following criteria
             apply:

        Disease related

          1. Histological or cytological confirmation of the diagnosis of mCRC

          2. Failure to respond or be intolerant of at least 2 prior regimens of standard
             anti-cancer treatments (study treatment must be 3rd-line or greater for mCRC).

             Failed prior treatments may include:

               -  Fluoropyrimidines-based chemotherapy

               -  Irinotecan-based chemotherapy

               -  Oxaliplatin-based chemotherapy

               -  Anti-Vascular Endothelial Growth Factor (VEGF) biological therapy

               -  Anti-Epidermal Growth Factor Receptor (EGFR) therapy, if RAS wild-type

               -  Immunotherapy (e.g., nivolumab, pembrolizumab and ipilimumab), in patients with
                  Microsatellite Instability High/Deficient Mismatch Repair (MSI-H/dMMR) Subjects
                  who had received adjuvant chemotherapy and had recurrence during or within 6
                  months of completion of the adjuvant chemotherapy would be considered as 1 prior
                  line of therapy

          3. Have progressed based on imaging during or within 3 months of the last administration
             of most recent standard therapy

          4. Have measurable disease, as defined by RECIST v1.1

             Laboratory

          5. Adequate bone marrow, renal, and hepatic function, as evidenced by the following
             within 7 days prior to study treatment

               -  Absolute neutrophil count (ANC) ≥1,500/mm3

               -  Platelets ≥75,000/mm3

               -  Hemoglobin ≥9.0 g/dL

               -  Creatinine clearance (according to Cockcroft-Gault Equation or by 24 hr urine
                  collection) > 50 mL/min and serum creatinine <1.0× ULN

               -  AST and ALT ≤3.0x ULN (≤5.0 × ULN for subjects with liver involvement of their
                  cancer)

               -  Bilirubin ≤1.5 × ULN

               -  Alkaline phosphatase ≤2.5 × ULN (≤5 × ULN with liver involvement of their cancer)

               -  INR/PTT ≤1.5 × ULN (Subjects currently under treatment with anti-thrombotic
                  agents such as warfarin or heparin with no abnormal coagulation values can
                  participate in this study)

          6. Urinary protein <2+ on dipstick or routine urinalysis. If urine dipstick or routine
             analysis indicates proteinuria ≥ 2+, a 24-hour urine or urine protein/creatinine ratio
             must be collected and must demonstrate <2 g of protein in 24 hours to allow
             participation in the study.

             Demographic

          7. Men and women at least 18 years of age at the time of study entry (or age of majority,
             if higher per local regulations)

          8. Have an Eastern Cooperative Oncology Group (ECOG) status of 0 or 1 Ethical/Other

          9. Able to understand and willing to provide written informed consent prior to enrollment
             in the study

         10. Female subjects who are of non-reproductive potential (i.e., post menopausal by
             history - no menses for ≥1 year; OR history of hysterectomy; OR history of bilateral
             tubal ligation; OR history of bilateral oophorectomy). Female subjects of childbearing
             potential must have a negative serum pregnancy test upon study entry.

         11. Male and female subjects of reproductive potential who agree to use both a highly
             effective method of birth control (eg, implants, injectables, combined oral
             contraceptives, some intrauterine devices, complete abstinence, or sterilized partner)
             and a barrier method (eg, condoms, cervical ring, sponge, etc.) during the period of
             therapy and for 3 months after the final dose of study drugs for male subjects and 6
             months after the final dose of study drugs for female subjects. Female subjects should
             also refrain from breastfeeding and egg donation and males should refrain from sperm
             donation throughout this period.

         12. In the assessment of the Investigator, subject is willing and able to comply with the
             protocol for the duration of the study including undergoing treatment and scheduled
             visits and examinations including follow up.

        Exclusion Criteria:

          -  Subjects will be excluded from the study if any of the following criteria apply:

        Disease-related

          1. Prior treatment with rivoceranib or trifluridine/tipiracil

          2. Prior treatment with other VEGFR small molecule inhibitors (eg, regorafenib)

          3. Packed red blood cell transfusion or erythropoietin therapy within 14 days prior to
             first dose of study drug

          4. History of another malignancy within 3 years prior to Cycle 1 Day 1. A subject with
             the following malignancies is eligible for this study if, in the opinion of the
             Investigator, they do not pose a significant risk to life expectancy:

               -  Carcinoma of the skin without melanomatous features

               -  Curatively treated cervical carcinoma in situ

               -  Bladder tumors considered superficial such as noninvasive (T1a) and carcinoma in
                  situ (Tis)

               -  Thyroid papillary cancer with prior treatment

               -  Prostate cancer which has been surgically or medically treated and not likely to
                  recur within 3 years

          5. Prior chemotherapy, radiation therapy or major surgery within 4 weeks prior to first
             dose of study drug or presence of any non-healing wound (a procedure such as catheter
             placement is not considered to be major surgery). Prior immunotherapy within 12 weeks
             prior to first dose of study drug. Palliative radiotherapy to non-target lesions
             within 2 weeks prior to first dose of study drug or biopsy within 1 week prior to
             first dose of study drug is permitted

          6. Active renal dysfunction that requires dialysis treatments

          7. Active cardiac disease including any of the following:

               -  Congestive heart failure New York Heart Association (NYHA) ≥Class 2

               -  Myocardial infarction less than 6 months before the start of Cycle 1 Day 1 of
                  treatment

          8. Cardiac arrhythmias requiring antiarrhythmic therapy (beta-blockers or digoxin are
             permitted)

          9. History of uncontrolled hypertension (blood pressure ≥140/90 mmHg and/or change in
             antihypertensive medication within 7 days prior to first dose of study drug)

         10. History of antiangiogenic drug class-related severe adverse reactions, including
             uncontrolled hypertension or others related to prior therapy discontinuation and/or
             those that may indicate a higher risk to a subject's safety, in the Investigator's
             opinion, if provided further antiangiogenic treatment.

         11. History of vascular disease including arterial or venous embolic events (pulmonary
             embolism), other than hypertension, within 6 months prior to Cycle 1 Day 1 (eg,
             hypertensive crisis, hypertensive encephalopathy, stroke or transient ischemic attack
             [TIA], or significant peripheral vascular diseases) that, in the Investigator's
             opinion, may pose a risk to the subject on VEGF inhibitor therapy.

         12. History of clinically significant thrombosis within 3 months prior to first dose of
             study drug that, in the Investigator's opinion, may place the subject at risk of side
             effects from antiangiogenics medications

         13. History of bleeding diathesis or clinically significant bleeding within 14 days prior
             to first dose of study drug

         14. Therapy with systemic anticoagulant or antithrombotic agents within 7 days prior to
             first dose of study drug that in the Investigator's opinion could interfere with
             clotting. The maximum allowable daily dose of aspirin is 325 mg

         15. Subjects with unstable seizure disorder requiring medication changes within 3 months
             of Cycle 1 Day 1 treatment

         16. Untreated or active central nervous system (CNS) or leptomeningeal metastases.
             Subjects are eligible if metastases have been treated and subjects are neurologically
             returned to baseline or neurologically stable (expect for residual signs and symptoms
             related to the CNS treatment) for at least 4 weeks prior to first dose of study drug.
             In addition, subjects must be either off corticosteroids, or on a stable dose or
             decreasing dose of ≤ 20 mg daily prednisone or prednisone-equivalent. A baseline
             radiological assessment of the brain will be performed on subjects who have prior
             history of metastases with CNS involvement

         17. History of clinically significant glomerulonephritis, biopsy-proven nephritis, crystal
             nephropathy or other renal insufficiencies

         18. Unresolved adverse reactions >Grade 1 excluding peripheral neuropathy or treatment
             related myelosuppression

         19. Known hypersensitivity to any of the study drugs, study drug classes, or any
             components of study drug formulations

         20. Inability to swallow oral medications

         21. An active malabsorption condition, or any other condition that in the opinion of the
             Investigator might affect the absorption of study drug Ethical/Other

         22. Psychiatric illness/social situations that would limit compliance with study
             requirements

         23. History of drug or alcohol abuse within past 5 years

         24. Known seropositive requiring antiviral therapy for human immunodeficiency virus (HIV)
             infection

         25. Known seropositive requiring antiviral therapy for hepatitis B virus (HBV) infection
             OR evidence of active hepatitis B infection by detectable viral load if the antibody
             tests are positive.

             NOTE: A positive-HBcAb subject with an undetectable surface antigen and negative
             hepatitis B DNA test (eg, polymerase chain reaction [PCR] test) can be enrolled

         26. Known seropositive requiring anti-viral therapy for hepatitis C virus (HCV) infection
             OR subjects with positive hepatitis C virus antibody (Ab).

             NOTE: A positive Anti-HCV subject with an undetectable/negative hepatitis C RNA test
             can be enrolled

         27. Participation in another clinical study with any investigational medication or product
             administered within 28 days prior to first dose of study drug

         28. Female subjects who are pregnant or breast-feeding

         29. Subjects unable or unwilling to discontinue excluded medications for at least 2 weeks
             prior to first dose of study drug

         30. Other serious conditions, in the Investigator's opinion