Inclusion Criteria:

          -  Age ≥18 years.

          -  For Phase Ib: Trial participants must have a histologically confirmed malignancy that
             is metastatic or unresectable for which standard curative or palliative measures do
             not exist or are no longer effective.

               1. For melanoma: trial participants must have either nivolumab or ipilimumab
                  available and have progressed on anti-PD1 or anti-PD1/anti-CTLA4 combination
                  therapy.

               2. For advanced solid tumors: trial participants must have nivolumab or therapy
                  available and must be appropriate for this therapy.

          -  For Phase II:

               1. Participants with melanoma who previously experienced disease progression on
                  anti-PD1 may enter the ARRY-614 plus nivolumab cohort or the ARRY-614 plus
                  ipilimumab cohort. Participants with melanoma entering the ARRY-614 plus
                  ipilimumab cohort must be naïve to ipilimumab therapy.

               2. Participants with RCC who previously experienced disease progression on anti-PD1
                  may enter the ARRY-614 plus nivolumab cohort

          -  Have an ECOG PS score of 0 or 1 (Appendix 13.A).

          -  Have an expected survival of ≥3 months.

          -  Have at least one evaluable and measurable lesion as defined by RECIST v1.1.

          -  The first five patients in each Phase II cohort must have tumors determined to be
             easily accessible for biopsy and must be willing to have two biopsies

          -  Have recovered from toxicities associated with prior anticancer therapy to baseline or
             Grade 1 unless stabilized under medical management per investigator.

          -  Have adequate bone marrow function as evidenced by:

               1. Absolute neutrophil count ≥1,500/mm3 or 1.5 ×109/L

               2. Hemoglobin ≥8 g/dL

               3. Platelets ≥100,000/mm3 or 100 × 109/L

          -  Have adequate hepatic function as evidenced by:

               1. Serum total bilirubin ≤2 × upper limit of normal (ULN), unless considered due to
                  Gilbert's disease

               2. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5x the
                  institutional ULN or ≤ 5.0x institutional ULN in the presence of known liver
                  metastases.

          -  Patients with creatinine clearance > 30 mL/min, (measured using Cockcroft-Gault
             equation or the estimated glomerular filtration rate from the Modification of Diet in
             Renal Disease Study) are included in the study.

          -  Be able to understand and willing to sign the informed consent form (or have legal
             representation) and to comply with scheduled visits, treatment plans, procedures, and
             laboratory tests, including serial peripheral blood sampling, biopsies, and urine
             sampling, during the study. A legally authorized representative may consent on behalf
             of a subject who is otherwise unable to provide informed consent if acceptable to and
             approved by the site's IRB/Independent Ethics Committee (IEC).

          -  Female patients with reproductive potential must have a negative serum pregnancy test
             prior to the start of therapy, or a confirmation from an obstetrician in case of
             equivocal serum pregnancy results. Females of reproductive potential are defined as
             sexually mature women who have not undergone a hysterectomy, bilateral oophorectomy,
             or tubal occlusion or who have not been naturally postmenopausal (ie, who have not
             menstruated) for at least 24 consecutive months (ie, have not had menses at any time
             in the preceding 24 consecutive months). Women with reproductive potential, as well as
             fertile men and their partners who are female with reproductive potential, must agree
             to use two effective forms of contraception (including at least one barrier form) from
             the time of giving informed consent throughout the study and for 5 months after the
             last dose of therapy for women, and 7 months after last dose for men. Effective forms
             of contraception are defined as hormonal PO contraceptives, injectables, patches,
             intrauterine devices, intrauterine hormone-releasing systems, bilateral tubal
             ligation, condoms with spermicide, or male partner sterilization.

          -  Patients positive for human immunodeficiency virus (HIV) are NOT excluded from this
             study, but HIV-positive patients must have:

               1. A stable regimen of highly active anti-retroviral therapy (HAART)

               2. No requirement for concurrent antibiotics or antifungal agents for the prevention
                  of opportunistic infections

               3. A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard
                  PCR-based test

        Exclusion Criteria:

          -  Received systemic anticancer therapy or an investigational agent <2 weeks prior to Day
             1 (washout from prior immune based anticancer therapy is 4 weeks). In addition, the
             first dose of study treatment should not occur before a period ≥5 half-lives of the
             investigational agent has elapsed (excluding nivolumab therapy or combination
             anti-PD1/ipilimumab combination therapy in RCC - prior ipilimumab not permitted in
             melanoma cohort).

          -  For ST, have underwent hepatic radiation, chemoembolization, and radiofrequency
             ablation <4 weeks prior to Day 1.

          -  Participants must not have had a prior anti-cancer monoclonal antibody (mAb) within 4
             weeks prior to study Day 1 (with exception of anti-PD1/ipilimumab combination therapy)
             or have not recovered (i.e. < Grade 1 at baseline) from adverse events due to agents
             administered more than 4 weeks earlier.

          -  Participants must not have a diagnosis of immunodeficiency or be receiving systemic
             steroid therapy at a dose of >10 mg prednisone daily or equivalent at time of first
             dose of trial treatment (this criterion does not apply to HIV-positive patients as
             detailed in the inclusion criteria).

          -  Participants must not have active autoimmune disease that has required systemic
             treatment in the past 2 years (i.e. with use of disease modifying agents,
             corticosteroids or immunosuppressive drugs). Replacement therapy (e.g. thyroxine,
             insulin, or physiologic corticosteroids replacement therapy for adrenal or pituitary
             insufficiency, etc.) is not considered a form of systemic treatment.

          -  Participants must not have a known history of non-infectious pneumonitis that required
             steroids for treatment.

          -  Participants must not have evidence of active interstitial lung disease.

          -  Have known symptomatic brain metastases requiring steroids. Patients with previously
             diagnosed brain metastases are eligible if they have completed their treatment and
             have recovered from the acute effects of radiation therapy or surgery prior to study
             entry, have discontinued corticosteroid treatment for these metastases for at least 1
             week and have radiographically stable disease for at least 1 month prior to study
             entry. Note: up to 10 mg per day of prednisone equivalent will be allowed.

          -  Have a history of another primary cancer that is active requiring treatment,
             progressing or for which the investigator believes will make disease assessment
             unreliable.

          -  Underwent major surgery within 4 weeks of Day 1 or have not recovered from
             post-surgery toxicities.

          -  Are pregnant or breastfeeding.

          -  Have an active infection requiring systemic anti-infective therapy or with an
             unexplained fever >38.5°C within 7 days of Day 1 (at the discretion of the
             Investigator, patients with tumor fever may be enrolled).

          -  Have any known hypersensitivity to any of the components of ARRY-614 or
             anti-PD1/ipilimumab combination therapies.

          -  Have significant active cardiac disease within 6 months prior to the start of study
             treatment, including New York Heart Association (NYHA) Class III or IV congestive
             heart failure); myocardial infarction; unstable angina; and/or stroke.

          -  Have known LVEF <40% by ECHO scan (or by other methods according to institutional
             practice) obtained within 28 days prior to the start of study treatment (testing is
             not otherwise mandatory).

          -  Have known active hepatitis B (HBV) or hepatitis C (HCV) infections. Patients with a
             sustained viral response to HCV treatment or immunity to prior HBV infection will be
             permitted. Patients with chronic HBV that is adequately suppressed per institutional
             practice will be permitted.

          -  Have any other acute or chronic medical or psychiatric condition, including recent
             (within 12 months of Day 1) or active suicidal ideation or behavior, or a laboratory
             abnormality that may increase the risk associated with study participation or
             investigational product administration or may interfere with the interpretation of
             study results and, in the judgment of the Investigator, would make the subject
             inappropriate for entry into this study.

          -  Have known active inflammatory gastrointestinal disease, chronic diarrhea, previous
             gastric resection or lap band dysphagia, short-gut syndrome, gastroparesis, or other
             conditions that limit the ingestion or gastrointestinal absorption of drugs
             administered PO. Gastroesophageal reflux disease under medical treatment is allowed
             (assuming no drug interaction potential).

          -  Have been committed to an institution by an order issued either by the judicial or
             administrative authorities.