Inclusion Criteria:

          1. Female ≥ 18 years of age at time of consent.

          2. Histologically confirmed invasive breast carcinoma documented by core needle biopsy or
             incisional biopsy (excisional biopsy is not allowed). AJCC clinical stage T1c, N0-3 or
             cT1, N1-3 by physical exam or radiologic studies. Suspected involvement of regional
             lymph nodes based on physical exam or imaging studies must be confirmed
             cytologically/histologically.

          3. Surgical excision of the primary breast tumor (partial mastectomy or total mastectomy)
             and ipsilateral axillary lymph node sampling (sentinel lymph node biopsy or axillary
             dissection) are planned following neoadjuvant chemotherapy.

          4. Estrogen Receptor (ER)- and Progesterone Receptor (PR)-negative, and Human Epidermal
             Growth Factor Receptor (HER)2-negative (triple-negative) cancer of the breast.

             Triple-negative tumors are defined as:

               -  ER- and PR-negative: less than or equal to 10% tumor staining by
                  immunohistochemistry (IHC) according to local pathology assessment.

               -  HER2-negative disease, defined as defined by ASCO/CAP guidelines [24]. Eastern
                  Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2 within 28 days
                  prior to study registration.

          5. Life expectancy of 6 months or greater as determined by the treating physician.

          6. Demonstrate adequate organ function as defined in the table below; all screening labs
             to be obtained within 28 days prior to registration.

             System Hematological Leukocytes

               -  2,500/mm3 Platelet count

               -  100,000/mm3 Absolute Neutrophil Count (ANC)

               -  1,500/mm3 Hemoglobin (Hgb)

               -  9.5 g/dL Renal Creatinine/Calculated creatinine clearance (CrCl) Cr < 1.5 x upper
                  limit of normal (ULN) or CrCl ≥ 50 mL/min using the Cockcroft-Gault formula
                  Hepatic Bilirubin Bilirubin ≤ 1.5 × ULN. Subjects with Gilbert's syndrome may
                  have a bilirubin > 1.5 × ULN, if no evidence of biliary obstruction exists
                  Aspartate aminotransferase (AST)

                    -  2.5 × ULN Alanine aminotransferase (ALT)

                    -  2.5 × ULN

          7. No evidence of distant metastases (M0 as per AJCC staging guidelines) Weekly
             Carboplatin for TNBC Confidential Protocol v.1.0, dated February 10, 2019 Page 19 of
             64

          8. Provided written informed consent and HIPAA authorization for release of personal
             health information, approved by an Institutional Review Board (IRB).

          9. NOTE: HIPAA authorization may be included in the informed consent or obtained
             separately.

         10. Women of childbearing potential (WOCP) must not be pregnant or breast-feeding. A
             negative serum or urine pregnancy test is required within 14 days of study
             registration. If the urine test cannot be confirmed as negative, a serum pregnancy
             test will be required.

         11. Women of childbearing potential (WOCP) must be willing to use two effective methods of
             birth control such as an oral, implantable, injectable, or transdermal hormonal
             contraceptive, an intrauterine device (IUD), use of a double barrier method (condoms,
             sponge, diaphragm, or vaginal ring with spermicidal jellies or cream), or total
             abstinence for the course of the study until 90 days after the last dose of study
             drug.

             NOTE: Women are considered to be of childbearing potential unless they are
             postmenopausal (≥45 years of age and has not had menses for greater than 12
             consecutive months or bilateral oophorectomy) or surgically sterile (bilateral tubal
             ligation or hysterectomy) or not heterosexually active for the duration of the study
             and at least 60 days after the last dose of study drug.

         12. As determined by the enrolling physician or protocol designee, ability of the subject
             to understand and comply with study procedures for the entire length of the study.

        Exclusion Criteria:

          1. Active infection requiring systemic therapy.

          2. Pregnant or breastfeeding (NOTE: breast milk cannot be stored for future use while the
             mother is being treated on study).

          3. Previous anti-cancer treatment (cytotoxic chemotherapy, immunotherapy, biologic
             therapy, radiotherapy directed towards the primary breast tumor and/or ipsilateral
             axillary lymph nodes or investigational agents) with therapeutic intent for the
             current breast cancer.

          4. Previous treatment with carboplatin, paclitaxel, doxorubicin, or cyclophosphamide
             within the past 3 years.

          5. Concurrent treatment with an ovarian hormonal replacement therapy or with hormonal
             agents such as raloxifene, tamoxifen or other selective estrogen receptor modulator
             (SERM). Subjects must have discontinued use of such agents prior to beginning study
             treatment.

          6. A history of seizure within 6 months prior to study entry.

          7. Pre-existing neuropathy from any cause in excess of Grade 1.

          8. Treatment with any investigational drug within 14 days prior to registration or within
             5 half-lives of the investigational product, whichever is longer.

          9. Major surgery within 14 days prior to registration or has not recovered from major
             side effects

         10. Any prior or concurrent malignancy whose natural history or treatment has the
             potential to interfere with the safety or efficacy assessment of this investigational
             regimen, as determined by the treating Medical Oncologist.

         11. Known history of AIDS (HIV testing is not mandatory). HIV-positive individuals on
             active HARRT therapy with virologic suppression (defined as an HIV-1 RNA level below
             the lower limit of detection of the assay used) within 90 days of study enrollment and
             a CD4 cell count >500 cells/mm3 on the most recent determination are eligible for the
             study.

         12. History of myelodysplastic syndrome or acute myeloid leukemia.

         13. Subjects with any of the following conditions:

               -  History of abdominal fistula, gastrointestinal perforation, or intra- abdominal
                  abscess within 28 days prior to registration.

               -  History of cerebrovascular accident (CVA) or transient ischemic attack within 6
                  months prior to registration.

               -  History of acute coronary syndromes (including myocardial infarction, unstable
                  angina, coronary artery bypass grafting, coronary angioplasty, or stenting) or
                  symptomatic pericarditis within 6 months prior to registration.

               -  Symptomatic congestive heart failure (New York Heart Association III-IV) or
                  documented current left ventricular (LV) systolic dysfunction with left
                  ventricular ejection fraction (LVEF) <50% on most recent assessment of LV
                  function.

               -  Clinically significant cardiac ventricular arrhythmias (e.g. sustained
                  ventricular tachycardia/ventricular fibrillation) or high-grade AV block (e.g.
                  bifascicular block, Mobitz type II and third-degree AV block) unless a pacemaker
                  is in place.

               -  Any concurrent severe and/or uncontrolled medical condition that would, in the
                  investigator's judgment, cause unacceptable safety risks, contraindicate subject
                  participation in the clinical study or compromise compliance with the protocol.

         14. Any condition that, in the opinion of the investigator, might jeopardize the safety of
             the patient or interfere with protocol compliance.

         15. Any mental or medical condition that prevents the patient from giving informed