The purpose of this study is to assess the efficacy and safety of treatment with olaparib
(MK-7339) in combination with pembrolizumab (MK-3475) in adults with previously treated,
advanced (metastatic and/or unresectable) Homologous Recombination Repair Mutation (HRRm)
and/or Homologous Recombination Deficiency (HRD)-positive solid tumors.
- Has a histologically- or cytologically-confirmed advanced (metastatic and/or
unresectable) solid tumor (except breast or ovarian cancers whose tumor has a germline
or somatic BRCA mutation) that is not eligible for curative treatment and for which
standard of care therapy has failed. Participants must have progressed on or be
intolerant to standard of care therapies that are known to provide clinical benefit.
There is no limit on the number of prior treatment regimens.
- Has either centrally-confirmed known or suspected deleterious mutations in ≥1 of the
specified 15 genes involved in HRR or centrally-confirmed HRD based on the Lynparza
- Has measurable disease per RECIST 1.1 as assessed by the local site
investigator/radiology and confirmed in real time by blinded independent central
review (BICR). BICR must confirm the presence of radiologically measurable disease per
RECIST 1.1 for the participant to be eligible for the study.
- Has a life expectancy of ≥3 months.
- Has an Eastern Cooperative Oncology Group (ECOG) performance status of either 0 or 1,
as assessed within 3 days of study treatment initiation.
- Male participants must agree to use contraception during the treatment period and for
≥120 days (4 months) after last dose of study treatment and refrain from donating
sperm during this period.
- Female participants must not be pregnant or breastfeeding, and ≥1 of the following
- Is not a woman of childbearing potential (WOCBP) OR
- Is a WOCBP who agrees to use contraception during the treatment period and for ≥180
days (6 months) after the last dose of study treatment.
- Has adequate organ function
- Has a known additional malignancy that is progressing or has required active treatment
in the last 3 years. Participants with basal cell carcinoma of the skin, squamous cell
carcinoma of the skin, ductal carcinoma in situ, or cervical carcinoma in situ that
has undergone potentially curative therapy are not excluded.
- Has a history of non-infectious pneumonitis that required treatment with steroids or
currently has pneumonitis.
- Has myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) or with features
suggestive of MDS/AML.
- Has known central nervous system (CNS) metastases and/or carcinomatous meningitis.
- Has an active infection requiring systemic therapy.
- Has active tuberculosis (Bacillus tuberculosis [TB]).
- Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
(dosing >10 mg daily of prednisone equivalent) or any other form of immunosuppressive
therapy within 7 days prior to the first dose of study treatment.
- Has an active autoimmune disease that has required systemic treatment in the past 2
years (i.e., with use of disease modifying agents, corticosteroids or
- Has received colony-stimulating factors (e.g. granulocyte colony-stimulating factor
[G-CSF], granulocyte-macrophage colony-stimulating factor [GM-CSF] or recombinant
erythropoietin) within 28 days prior to the first dose of study treatment.
- Has a known history of human immunodeficiency virus (HIV) infection.
- Has known active hepatitis B or hepatitis C.
- Is unable to swallow orally administered medication or has a gastrointestinal (GI)
disorder affecting absorption (e.g. gastrectomy, partial bowel obstruction,
- Has received prior therapy with an anti-programmed death-1 (anti-PD-1),
anti-programmed death-ligand 1 (anti-PD-L1), or anti-programmed death-ligand 2
(anti-PD-L2) agent or with an agent directed to another stimulatory or co-inhibitory
T-cell receptor (e.g. cytotoxic T-lymphocyte-associated protein 4 [CTLA-4], OX 40
[Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4)], CD137 [tumor
necrosis factor receptor superfamily member 9 (TNFRSF9)]).
- Has received prior therapy with olaparib or with any other polyadenosine 5'
diphosphoribose (poly[ADP ribose]) polymerization (PARP) inhibitor.
- Was refractory to prior platinum therapy (cisplatin, carboplatin, or oxaliplatin
either as monotherapy or in combination) for advanced (metastatic and/or unresectable)
- Has received prior systemic anti-cancer therapy including investigational agents
within 4 weeks prior to administration of study treatment.
- Must have recovered from all adverse events (AEs) due to previous therapies, excluding
alopecia, to ≤Grade 1 or Baseline.
- Has a known hypersensitivity to the study treatments and/or any of their excipients.
- Is currently receiving either strong inhibitors of cytochrome P450 (CYP)3A4 (e.g.
itraconazole, telithromycin, clarithromycin, protease inhibitors boosted with
ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or
moderate inhibitors of CYP3A4 (e.g. ciprofloxacin, erythromycin, diltiazem,
fluconazole, verapamil) that cannot be discontinued for the duration of the study. The
required washout period prior to starting olaparib is 2 weeks.
- Is currently receiving either strong inducers of CYP3A4 (phenobarbital, enzalutamide,
phenytoin, rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's
Wort) or moderate inducers of CYP3A4 (e.g. bosentan, efavirenz, modafinil) that cannot
be discontinued for the duration of the study. The required washout period prior to
starting olaparib is 5 weeks for phenobarbital and 3 weeks for other agents.
- Has received previous allogenic bone-marrow transplant or double umbilical cord
- Has received a whole blood transfusion in the last 120 days prior to entry to the
- Has received prior radiotherapy within 2 weeks of start of study treatment.
- Is currently enrolled in and receiving study therapy, was enrolled in a study of an
investigational agent and received study therapy or used an investigational device
within 4 weeks (28 days) of the first dose of study treatment.
- Has resting electrocardiogram (ECG) indicating uncontrolled, potentially reversible
cardiac conditions, as judged by the investigator (e.g. unstable ischemia,
uncontrolled symptomatic arrhythmia, congestive heart failure, corrected QT interval
by Fredericia [QTcF] prolongation >500 msec, electrolyte disturbances), or participant
has congenital long QT syndrome.
- Has either had major surgery within 2 weeks of starting study treatment or has not
recovered from any effects of any major surgery.
- Has received a live vaccine within 30 days prior to the first dose of study treatment.